2013 American Transplant Congress
Compartmentalization of Acute Versus Chronic Rejection in Cardiac Allografts
Immunology, Cleveland Clinic, Cleveland, OH
Acute rejection of cardiac allografts is characterized by interstitial infiltrates and diagnosed by endomyocardial biopsies. In contrast, chronic rejection is distinguished by vasculopathy in large…2013 American Transplant Congress
Rapamycin-Induced Augmentation of the CD8 T Cell Response to a Latent Viral Infection Is Inhibited by CTLA4-Ig
Latent viral infections are a major concern among immunosuppressed transplant patients. Treatment with belatacept, a CTLA4-Ig fusion protein, was shown to reduce toxicity in kidney…2013 American Transplant Congress
Impact of Cholecalciferol Repletion on Alloreactivity in Vitamin D-Deficient Hemodialysis Patients: A Randomized Controlled Trial
Dept of Medicine, Mount Sinai School of Medicine, NY, NY
Background: 25OH-Vit D deficiency is common in hemodialysis (HD) patients despite therapy with 1,25OH-Vit D, and is associated with increased T cell memory. The purpose…2013 American Transplant Congress
Epitope Matching Outperforms Traditional Antigen Matching as a Predictor of De Novo Donor Specific Antibody Development after Renal Transplantation
Hypothesis:An epitope based HLA matching approach will be predictive of de novo Donor Specific Antibody (dnDSA) development after renal transplantation.Methods:315 consecutive renal transplants were performed…2013 American Transplant Congress
Therapeutic Dosing of Mycophenolate Mofetil (MMF) in Renal Allograft Recipients Decreases with Increasing Age
PinnacleHealth, Harrisburg, PA
Background: Measurement of 2-hour Mycophenolic Acid Area-Under-Cure (MPA AUC) has been shown to allow accurate dosing of MMF for therapeutic efficacy. While inadequate MMF administration…2013 American Transplant Congress
Evolving Face of Liver Donors: Updating the Donor Risk Index, The
Background Derived from 1998-2002 liver transplant (LT) data, the DRI has served as a common language to analyze LT utilization practices and outcomes. We examined…2013 American Transplant Congress
Cell Necrosis and Immune Activation: Does Injury Alter Acquired Alloimmunity?
Emory Transplant Center, Atlanta, GA
Adaptive immune responses are directed by specific recognition of antigen but are also driven by general contextual signs of injury. Organ transplantation provides both of…2013 American Transplant Congress
UNOS Regional Risk Factors for Graft Failure in Kidney Transplantation
Aim: To identify UNOS regional variations in graft failure.Methods: UNOS database of 17,273 adult recipients transplanted from 06-30-2004 to 01-01-2007. Potential risk factors of interest…2013 American Transplant Congress
HLA-G Polymorphism, a Molecule Involved in Materno-Fetal Tolerance Is Associated with a Reduction of Acute Rejection and Improved Graft Survival in Renal Transplantation
Introduction: Few markers of good outcome of kidney transplants have been demonstrated. We have shown that HLA-G, a protein belonging to the non-classical class I…2013 American Transplant Congress
Long-Term Satisfaction with Life after Living Kidney Donation: A RELIVE Study
Background:Little is known about the long-term satisfaction with life (SWL) of live kidney donors. We surveyed SWL among a population of kidney donors participating in…
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