ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    Update on Phase 2 Clinical Trial To Induce Tolerance in Mismatched Living Donor Renal Transplant Recipients

    J. Leventhal, M. Abecassis, J. Miller, L. Gallon, K. Ravindra, D. Tollerud, B. King, M. Elliott, G. Herzig, R. Herzig, S. Ildstad

    Northwestern University, Chicago, IL; Institute for Cellular Therapeutics, University of Louisville, Louisville, KY; James Graham Brown Cancer Ctr, University of Louisville, Louisville, KY; Regenerex, LLC, Louisville, KY

    19 subjects have been enrolled in a phase 2 protocol (FDA IDE 13947) to induce tolerance in mismatched recipients of living donor renal allografts (KTx).…
  • 2013 American Transplant Congress

    Mesenchymal Stem Cell Therapy To Promote Functional Recovery in a Limb Transplant Model

    E. Fitzpatrick, M. DeHart, J. Tercero, T. Brown, S. Salgar

    Clinical Investigation, MAMC; Surgery, Madigan Army Medical Center, Tacoma, WA

    Introduction: Hand and leg transplantation (Tx) in military and civilian populations is increasingly needed to improve the quality of life of individuals. Optimizing nerve regeneration…
  • 2013 American Transplant Congress

    Product of Donor Age and Preoperative MELD, D−MELD, Predicts Surgical Outcomes after LDLT in HCV Positive Recipients, but Not in HCV Negative Recipients, The

    A. Tanemura, S. Mizuno, N. Kuriyama, Y. Azumi, I. Osawa, M. Kishiwada, M. Usui, H. Sakurai, M. Tabata, S. Isaji

    Hepatobiliary-Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Tsu, Japan

    Background:Donor age and MELD score are recognized as risk factors affecting recipient outcomes in living donor liver transplantation (LDLT). The aim of this study is…
  • 2013 American Transplant Congress

    Undetected Lesion as a Risk Factor for Recurrence in Patients Transplanted for HCC, The

    L. Teperman, E. Cahan, A. David, B. Gelb, G. Morgan, H. Tobias

    NYU SOM, New York, NY; U of M, Ann Arbor, MI

    Background: OLT is the definitive treatment for HCC. Vascular invasion, tumor size, and proliferation are known risk factors for recurrence post-OLT. Undetected lesions <1cm are…
  • 2013 American Transplant Congress

    Peripheral Expression of Inflammatory Proteins and miRNAs Expression at the Time of Biopsy Proven ACR and Persistence of Immune Activation Long after Clinical Resolution

    A. Shaked, J. Tobias, N. Goodrich, B. Gillespie, the A2ALL Study Group

    U of Pennsylvania, Philadelphia, PA; Arbor Research Collaborative for Health, Ann Arbor, MI; U of Michigan, Ann Arbor, MI

    The aim of this exploratory study was to determine whether inflammatory proteins and/or miRNA in serum specimens collected at the time of biopsy-proven rejection (ACR),…
  • 2013 American Transplant Congress

    Children Develop De Novo Anti-HLA Antibodies (Abs) Following Kidney Transplantation at a Higher Incidence Than Adults: An Analysis of the NIH CTOT/CCTPT-02 Study

    W. Harmon, I. Guleria, D. Ikle, B. Armstrong, L. Spaneas, Y. Morrison, N. Bridges, M. Sayegh, A. Chandraker

    Boston Children's Hospital and Brigham and Women's Hospital, Harvard Medical School, Boston, MA; RHO, Chapel Hill, NC; NIAID, NIH, Bethesda, MD

    The NIH CTOT/CCTPT-02 examined the development of post transplant de novo anti-HLA Abs in unsensitized kidney transplant recipients. It is a multi-center observational study that…
  • 2013 American Transplant Congress

    Influence of Steroid Maintenance on the Outcomes in Sensitized Kidney Transplant Recipients

    K. Sureshkumar, K. Nashar, S. Hussain, T. Ko, N. Thai, P. Abrams, R. Marcus

    Nephrology and Hypertension, Allegheny General Hospital, Pittsburgh, PA; Abdominal Transplantation, Allegheny General Hospital, Pittsburgh, PA

    Steroid withdrawal protocols are increasingly used in kidney transplantation. However, sensitized patients considered high immune risk are maintained on steroid by many centers. It is…
  • 2013 American Transplant Congress

    IL37 Controls IL18 Induced Pro-Inflammatory Cytokine Expression by Tubular Cells and Attenuates Renal Ischemia-Reperfusion Injury

    Y. Yang, Z. Yin, S. Ma, Z. Zhang, A. Jevnikar

    Matthew Mailing Centre for Translational Transplantation Studies, London Health Sciences Centre, London, Canada; Pathology, Western University, London, Canada; Medicine, Western University, London, Canada; Biology, Western University, London, Canada

    IL37 is a newly described member of the IL-1 family,which is anti-inflammatory by its inhibition of pro-inflammatory cytokine production. While human IL37 has no murine…
  • 2013 American Transplant Congress

    Compartmentalization of Acute Versus Chronic Rejection in Cardiac Allografts

    A. Kaul, H. Yu, N. Dvorina, W. Baldwin

    Immunology, Cleveland Clinic, Cleveland, OH

    Acute rejection of cardiac allografts is characterized by interstitial infiltrates and diagnosed by endomyocardial biopsies. In contrast, chronic rejection is distinguished by vasculopathy in large…
  • 2013 American Transplant Congress

    Rapamycin-Induced Augmentation of the CD8 T Cell Response to a Latent Viral Infection Is Inhibited by CTLA4-Ig

    D. Pinelli, M. Wagener, M. Ford

    Emory University, Atlanta, GA

    Latent viral infections are a major concern among immunosuppressed transplant patients. Treatment with belatacept, a CTLA4-Ig fusion protein, was shown to reduce toxicity in kidney…
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