ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    Clinical Outcomes in a Phase 1b, Randomized, Double-Blind, Parallel Group, Placebo-Controlled, Single-Dose Study of ASKP1240 in De Novo Kidney Transplantation

    F. Vincenti, H. Yang, G. Klintmalm, S. Steinberg, L. Wang, W. Zhang, A. Conkle, P. Blahunka, R. First, J. Holman

    University of California San Francisco, San Francisco, CA; Pinnacle Health, Harrisburg, PA; Baylor Transplant Institute, Dallas, TX; Sharp Memorial Hospital, San Diego, CA; Astellas Pharma Global Development, Northbrook, IL

    Objective was to evaluate safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of ASKP1240, a fully human anti-CD40 monoclonal antibody, administered following a de novo kidney…
  • 2013 American Transplant Congress

    Oral Administration of Ginseng Delays Aging Process by Upregulating Anti-Aging Gene, Klotho, in Chronic Cyclosporine Nephropathy

    S. Lim, K. Doh, S. Piao, S. Heo, B. Chung, C. Yang

    Convergent Research Consortium for Immunologic Disease, Seoul, Republic of Korea; Transplant Research Center, Seoul, Republic of Korea; Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea

    Background: Chronic cyclosporine (CsA) nephropathy is associated with an accelerated ageing process. Recently, we found that ginseng treatment reduced the progression of chronic CsA nephropathy.…
  • 2013 American Transplant Congress

    Anti-Hyperglycemic Effect of Ginseng on Cyclosporine-Induced Diabetes Is Related to the Direct Pancreatic Islet Cell Protection

    S. Lim, K. Doh, L. Jin, S. Piao, S. Heo, Y. Zheng, S. Bae, B. Chung, C. Yang

    Convergent Research Consortium for Immunologic Disease, Seoul, Republic of Korea; Transplant Research Center, Seoul, Republic of Korea; Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, Seoul, Republic of Korea; College of Pharmacy, The Catholic University of Korea, Seoul, Republic of Korea; College of Pharmacy, Seoul National University, Seoul, Republic of Korea

    Background: The study was performed to investigate whether ginseng has protective effect in an experimental mouse model of cyclosporine (CsA)-induced pancreatic injury.Methods: Mice were treated…
  • 2013 American Transplant Congress

    Oral Treatment of Multi-Drug Resistant Urinary Tract Infection in Transplant Recipients: Resurgence of Fosfomycin

    B. Noell, N. Wilson, A. Haririan, M. Jason, C. Davis, M. Weir, S. Bartlett, J. Bromberg, W. Manitpisitkul

    University of Maryland Medical Center, Baltimore, MD

    Background: With repeated exposure to antimicrobials, development of MDR bacterial infections pose a serious clinical problem in organ transplant recipients. Generally, these type of infections…
  • 2013 American Transplant Congress

    Impact of CMS CoP on Kidney Transplant Waiting Times, The

    K. Schnier, C. McIntyre, R. Ruhil, V. Sadiraj, J. Cox, T. Pearson, A. Kirk, N. Turgeon

    Department of Economics, Georgia State University, Atlanta, GA; Emory Transplant Center, Emory University, Atlanta, GA

    Background: SRTR program reports provide detailed information on transplant center performance relative to risk-adjusted values. Although designed to improve outcomes, the behavioral implications of these…
  • 2013 American Transplant Congress

    Results about, and Algorithms For, Robust Probabilistic Kidney Exchange Matching

    J. Dickerson, A. Procaccia, T. Sandholm

    Computer Science Department, Carnegie Mellon University, Pittsburgh, PA

    For a variety of practical reasons, including crossmatch failures, most planned kidney exchange transplants do not go to transplant in reality. This is arguably the…
  • 2013 American Transplant Congress

    TCR-Directed Immune Therapy Restores Self Tolerance and Significantly Prolongs Islet Allograft Survival in Diabetic NOD Mice

    P. Schroder, M. Khattar, R. Deng, C. Baum, B. Mierzejewska, S. Stepkowski

    Medical Microbiology & Immunology, University of Toledo College of Medicine, Toledo, OH

    Background: A major barrier for islet transplantation is the lack of an immunotherapy to control both the allo- and autoimmune responses. Methods: In this study,…
  • 2013 American Transplant Congress

    Causes of Rejection and Non Utilization of Live Liver Donors: A Single Center Experience

    S. Kashkoush, M. Akhtar, B. Hegab, S. Alshlwi, W. O'Hali, K. Abdullah

    Hepatobiliary Surgery and Liver Transplantation, King Fahad National Guard Hospital, Riyadh, Saudi Arabia

    Background: Proper selection of live liver donors is crucial for both donor safety and transplant recipient outcome. Non utilization of possible live donors is multifactorial…
  • 2013 American Transplant Congress

    Improving Value after Pediatric Liver Transplant: Discharge Practices of High-Performing Centers

    B. Kelly, M. Englesbe, J. Bucuvalas, W. Andrews, J. Mitchell, R. Anand, W. Yin, J. Magee, G. Mazariegos, S. Horslen

    SPLIT Quality Improvement Committee, Nashville; University of Michigan, Ann Arbor; University of Cincinnati, Cincinnati; Children's Mercy Hospital, Kansas City; EMMES Corporation, Rockville; Children's Hospital of Pittsburgh, Pittsburgh; University of Washington, Seattle

    We sought to improve value (outcomes/cost) for the initial hospitalization after pediatric liver transplantation (LT) by identifying variation in length of stay (LOS), a highly…
  • 2013 American Transplant Congress

    Obesity Does Not Adversely Affect the Outcomes of Kidney Transplantation

    I. Begov, S. Akkina, E. Benedetti, I. Tang

    Medicine, University of Illinois Medical Center, Chicago, IL; Surgery, University of Illinois Medical Center, Chicago, IL

    Obese patients with end stage kidney disease encounter difficulties obtaining kidney transplantation (KTx) because of concern for shorter graft and patient survival. We examined the…
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