2013 American Transplant Congress
Comparative Effectiveness of Rabbit Anti-Thymocyte Globulin vs. Interleukin-2 Receptor Blockers in Deceased Donor Kidney Transplants with Delayed Graft Function, The
Department of Medicine, Division of Nephrology, University of Toronto, Toronto, ON, Canada
Background: To date, studies addressing outcomes of depleting (i.e., rabbit anti-thymocyte globulin or rATG) vs. non-depleting (i.e., IL-2 receptor blocker or IL2RB) induction strategies in…2013 American Transplant Congress
Histopathologic Scoring and Outcomes in Transplant Glomerulopathy (TG)
Introduction: TG is associated with poor allograft survival and there are limited treatment options. Some report improved outcomes with rituximab. Histopathologic scoring might predict prognosis…2013 American Transplant Congress
Increasing HLA DR Mismatches Is Associated with Inferior Kidney Allograft Outcome in Low Immune Risk Living Donor Kidney Transplant Recipients
Background: HLA DR mismatches (MM) have been shown to negatively influence kidney allograft outcomes in historical cohorts. We examined whether this effect persists in the…2013 American Transplant Congress
Classification of Kidney Transplant Recipients Using a Combination of Estimated GFR and Albuminuria Reflects Prognosis
The 2002 NKF-K/DOQI Chronic Kidney Disease (CKD) classification scheme, based largely on the estimated glomerular filtration rate (eGFR), has been criticized for failing to adequately…2013 American Transplant Congress
Effect of Vasodilators on Organ Function during Normothermic Machine Perfusion of Porcine DCD Liver, The
Cleveland Clinic, Cleveland, OH; Case Western Reserve University, Cleveland, OH
Introduction: Shortage of donor livers and prolonged wait list mortality has lead to the need of using extended criteria donors. Donation after Cardiac Death (DCD)…2013 American Transplant Congress
Risk Factors for Graft Failure and Death in Elderly (>65 Years Old) Kidney Transplant Recipients
Background:Kidney transplantation outcomes in the elderly have been favorable but detailed accounts of these outcomes from non-registry data is limited.Purpose:The purpose of this study was…2013 American Transplant Congress
Predicting Graft Failure in Kidney Transplant Patients: A Combined Clinical/Molecular Approach to Analyzing Biopsies
We combined an existing dataset with new data from a multi-centre international collaboration (INTERCOM), to predict graft loss in a patient population undergoing kidney transplant…2013 American Transplant Congress
Rapamycin and CTLA4-Ig Demonstrate Age-Specific Effects on Transplant Outcome and Immune Responses
Surgery, Brigham and Women's Hospital, Boston, MA
Elderly patients constitute the fastest growing proportion of organ transplant recipients. Whether immunosuppression needs to be adapted in an age-dependent manner or if immunosuppressants have…2013 American Transplant Congress
Clinical Outcomes in a Phase 1b, Randomized, Double-Blind, Parallel Group, Placebo-Controlled, Single-Dose Study of ASKP1240 in De Novo Kidney Transplantation
Objective was to evaluate safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of ASKP1240, a fully human anti-CD40 monoclonal antibody, administered following a de novo kidney…2013 American Transplant Congress
Oral Administration of Ginseng Delays Aging Process by Upregulating Anti-Aging Gene, Klotho, in Chronic Cyclosporine Nephropathy
Background: Chronic cyclosporine (CsA) nephropathy is associated with an accelerated ageing process. Recently, we found that ginseng treatment reduced the progression of chronic CsA nephropathy.…
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