ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    Endothelial-to-Mesenchymal Transition Contributes to Cardiac Allograft Rejection and Vasculopathy

    Y. Xiao, Z. Mao, H. Liu

    Thoracic, Renmin Hospital of Wuhan University, Wuhan, Hubei, China; Surgery, Children' Hospital, Boston, MA

    The chronic allograft rejection, i.e. transplant vasculopathy (TV), is a major limiting factor in the long-term success of cardiac transplantation. In the present study, we…
  • 2013 American Transplant Congress

    Transplantation Tolerance That Depends on Regulatory T Cells Induced by TGF-beta-Producing Regulatory B Cells

    J. Kim, K. Lee, G. Zhao, R. Stott, J. Soohoo, M. Lian, L. Fitzgerald, H. Yeh, S. Deng, J. Markmann

    Surgery, Massachusetts General Hospital, Boston, MA; Surgery, Sichual Provincial People's Hospital, Chengdu, Sichuan Province, China; Tufts Medical School, Boston, MA

    Regulatory B cells (Bregs) have been shown to play a critical role in immune homeostasis and in autoimmunity models. We have recently demonstrated that combined…
  • 2013 American Transplant Congress

    Does Ex-Situ Atraumatic Retrograde Hepatic Artery Perfusion in Pediatric Living Donor Liver Transplantation Reduce the Incidence of Anastomotic Biliary Strictures?

    T. Darius, J. Rivera, C. de Magnee, R. Reding

    Pediatric Liver Transplant Program, Université Catholique de Louvain, Brussels, Belgium; Transplant Unit, Fundación Cardioinfantil IC, Bogotá, Colombia

    Background. Using left living donor grafts, the local ischemia of the left bile duct stump has been suspected to play a crucial role in post-transplant…
  • 2013 American Transplant Congress

    Kidney-Induced Cardiac Allograft Tolerance across a Full MHC-Barrier in Miniature Swine

    M. Madariaga, S. Michel, M. Tasaki, V. Villani, E. Farkash, G. La Muraglia II, J. Allan, D. Sachs, K. Yamada, J. Madsen

    Cardiothoracic Transplantation Laboratory, Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA

    We have previously demonstrated that a kidney allograft has the ability to confer tolerance on a co-transplanted heart allograft procured from a class I-mismatched donor.…
  • 2013 American Transplant Congress

    Prevascularized Tissue-Engineered Construct Serves as an Alternative Site for Pancreatic Islet Transplantation, A

    G. Zhao, M. Yang, L. Wei, X. Huang, J. Lei, J. Markmann, S. Deng

    Department of Surgery, Sichuan Provincial People's Hospital, Chengdu, Sichuan Province, China; Transplant Unit, Massachusetts General Hospital, Boston, MA

    Although the sites for clinical or experimental islet transplantation have been well established, the pancreatic islet survival and function in homing locations still remain unsatisfied.…
  • 2013 American Transplant Congress

    Intrahepatic Natural Killer Cells Highly Expressing NKp46 Inhibit Early-Phase Post-Transplant Hepatitis C Virus Replication

    N. Tanimine, Y. Tanaka, H. Ohdan

    Department of Surgery, Hiroshima University, Hiroshima City, Kasumi 1-2-3, Minami-ku, Japan

    [Aim] The role of NK cells in pathophysiology of HCV infection was not entirely clear. Understanding the function of NK cells in HCV-infected patients may…
  • 2013 American Transplant Congress

    Heat Shock Protein 90 Is Involved in Antibody-Mediated Rejection and Is a Potential Target of Anti-Rejection Therapy in Kidney Transplantation

    T. Tanaka, H. Ishida, M. Furusawa, Y. Tamura, H. Kitamura, S. Takahashi, N. Masumori, K. Tanabe, N. Sato, T. Tsukamoto

    Urology, Sapporo Medical University, Sapporo, Japan; Urology, Tokyo Women's Medical University, Tokyo, Japan; Pathology, Sapporo Medical University, Sapporo, Japan

    Purpose: Heat shock protein 90 (HSP90) is a ubiquitously expressed molecular chaperone that is associated with the correct activation of client proteins. Important roles of…
  • 2013 American Transplant Congress

    Treatment of Cryptococcosis in Solid-OrganTransplant Recipients: Relapse Is Rare after Discontinuation of Therapy

    J. Baddley, B. Klausing, K. Brizendine, V. Kumar, B. Julian, D. Eckhoff, J. Tallaj, K. Wille, S. Moser, P. Pappas

    University of Alabama at Birmingham, Birmingham, AL; Birmingham VAMC, Birmingham, AL; Cleveland Clinic, Cleveland, OH

    Background: Cryptococcosis is the third most common fungal infection in solid- organ transplant (SOT) recipients. Current treatment guidelines recommend 6-12 months of antifungal therapy; however,…
  • 2013 American Transplant Congress

    Conversion to a Sirolimus-Based Regimen Is Associated with Lower Incidence and Faster Resolution of BK Viremia in Low Risk Kidney Transplant Recipients

    F. Tohme, R. Kalil, C. Thomas

    Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa city, IA

    Background: BK nephropathy is a leading cause of early graft loss in kidney transplant recipients. It is not known if a specific immunosuppressive agent is…
  • 2013 American Transplant Congress

    Acute Kidney Injury in Kidney Transplant Patients According to the Rifle and Akin Criteria

    T. Filiponi, A. Silva-Filho, L. Requião-Moura, E. Tonato, E. Arruda, R. Chinen, L. Mello, A. Bertocci, M. Durão Junior

    Renal Transplantation, Albert Einstein Israelita Hospital, São Paulo, Brazil

    A. PurposeTo assess the incidence, risk factors and outcomes associated with acute kidney injury (AKI) in kidney transplant in-patients using RIFLE (R-risk, I-Injury, F-failure, L-loss,…
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