ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    Comparison of Gene Expression in Heart Beating and Non Heart Beating Donor Kidney, A

    T. Saat, D. Susa, H. Roest, N. Kok, S. van den Engel, J. IJzermans, R. de Bruin

    Experimental Surgery, Erasmus University Medical Centre, Rotterdam, Netherlands

    The superior long-term survival of kidneys from living donors (LD) compared to brain death (BD) or non heart beating (NHB) donors is now well established.…
  • 2013 American Transplant Congress

    T-Cell Mediated Rejections Do Not Induce De Novo Donor Specific Antibodies in Non-Sensitized Kidney Transplant Recipients: A Longitudinal Cohort Analysis

    J. Chemouny, C. Suberbielle, A. Loupy, C. Legendre, D. Anglicheau

    Transplantation Rénale Adulte, Hôpital Necker-Enfants Malades/Assistance Publique-Hôpitaux de Paris, Paris, France, Metropolitan; Laboratoire Régional d'Histocompatibilité, Hôpital Saint-Louis/Assistance Publique-Hôpitaux de Paris, Paris, France, Metropolitan

    Humoral allo-immunity is a major determinant of kidney graft survival, and de novo donor specific anti-HLA antibodies (dnDSA) are associated with an increased risk of…
  • 2013 American Transplant Congress

    MICA A5.1 Mutation Is an Immunodominant Factor, Promoting MICA Expression on Graft Endothelial Cells and MICA Alloimmunisation, and a Potential Risk Factor for Transplant Survival

    B. Charreau, P. Tonnerre, N. Gerard, C. Poli, S. Allard, S. Cury, C. Bressollette, A. Cesbron-Gautier

    INSERM UMR1064, Nantes, France; Laboratoire HLA, Etablissement Français du Sang, Nantes, France; EA4271, Université de Nantes, Nantes, France

    Clinical findings suggest a role for donor MHC class I-related chain A (MICA) antigens expressed on transplant endothelial cells (ECs) in the alloimmune response. However,…
  • 2013 American Transplant Congress

    Monitoring of Soluble Urokinase-Type Plasminogen Activator Receptor (suPAR) in Patients with Focal Segmental Glomeruloscerosis (FSGS) Undergoing Kidney Transplantation

    F. Halleck, O. Staeck, D. Khadzhynov, M. Duerr, M. Naik, L. Liefeldt, I. Lieker, T. Slowinski, H. Neumayer, K. Budde

    Dpt. of Nephrology, Charité Universitaetsmedizin Campus Mitte, Berlin, Germany

    Background: suPAR was shown to be elevated in approximately 60% of patients (pts) with primary FSGS. Increased levels before transplantation were predictive of FSGS recurrence,…
  • 2013 American Transplant Congress

    Clinical Impact of an ACE Insertion/Deletion and Kinin B2 Receptor +9/-9 Polymorphisms in the Prognosis of Renal Transplantation

    C. Amorim, S. Almeida, P. Gomes, R. Bacurau, N. Camara, R. Araujo

    UNIFESP, Sao Paulo, Brazil; UNIFESP, Sao Paulo, Brazil; USP, Sao Paulo, Brazil

    There is a consensus in the scientific literature that supports the importance of the kallikrein kinin and renin angiotensin systems in renal physiology, but notably…
  • 2013 American Transplant Congress

    Geographic Variation May Explain Disparities in Pediatric Waiting List Times for Hispanic Children

    S. Amaral, J. Hwang, J. Shults, V. Potluri, P. Abt, P. Reese

    Pediatrics, The Children's Hosp of Phila, Philadelphia, PA; Biostatistics and Epidemiology, Univ of Pennsylvania, Philadelphia, PA; Surgery, Univ of Pennsylvania, Philadelphia, PA

    Body: Black and Hispanic children with end-stage renal disesase (ESRD) experience longer waiting times for deceased donor kidney transplantation. However, prior studies have not examined…
  • 2013 American Transplant Congress

    Three-Year Safety and Efficacy Outcomes in Kidney Transplant Patients Randomized to Steroid Avoidance or Maintenance Steroids with Early Intensified Dosing of Enteric-Coated Mycophenolate Sodium: The INFINITY Study

    A. Thierry, G. Mourad, M. Büchler, N. Kamar, F. Villemain, A. Heng, Y. Le Meur, G. Choukroun, O. Toupance, C. Legendre, P. Le Pogamp, M. Kessler, P. Merville, B. Moulin, S. Quéré, A. Lécuyer, F. Di Giambattista, G. Touchard

    Service de Néphrologie et Transplantation Rénale, Hôpital La Milétrie, Poitiers, France; , For the INFINITY Study Group, France; Novartis Pharma SAS, Rueil-Malmaison, France

    Short-term intensified enteric-coated mycophenolate sodium (EC-MPS) dosing may facilitate steroid avoidance (SA) after kidney transplantation.Methods. De novo kidney transplant recipients at low immunological risk (PRA…
  • 2013 American Transplant Congress

    Influence of Plasmapheresis on the Concentration of Soluble Urokinase Receptor (suPAR) in Patients with Focal Segmental Glomerulosclerosis (FSGS)

    O. Staeck, D. Khadzhynov, F. Halleck, M. Duerr, M. Naik, L. Liefeld, I. Lieker, T. Slowinski, H. Peters, H. Neumayer, K. Budde

    Department of Nephrology, Charité Universitaetsmedizin Berlin, Berlin, Germany

    Background: suPAR is elevated in patients (pts) with FSGS. Increased levels were associated with recurrence in transplanted kidneys. Previous studies suggested a causative role in…
  • 2013 American Transplant Congress

    Integrated Analysis of MHC Class I-Like (MICA, HLA-E and EPCR) Genetic Diversity in Kidney Transplant Donors and Graft’s Endothelial Cell Phenotype

    B. Charreau, N. Gerard, P. Tonnerre, P. Gavlovsky, A. Pabois, C. Guitton

    INSERM UMR1064, Nantes, France

    Although, there is evidence for a role of MICA, HLA-E and EPCR in vascular transplant biology and immunology, genotyping is not routinely achieved and correlation…
  • 2013 American Transplant Congress

    Differential Effects of the Innate vs. Adaptive Immunity in Lysing Human Renal Tubular Epithelial Cells

    M. Demmers, S. Korevaar, J. IJzermans, M. Betjes, W. Weimar, A. Rowshani, C. Baan

    Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands; Surgery, Erasmus Medical Center, Rotterdam, Netherlands

    Introduction At present, the relative contribution of the innate and adaptive cytotoxic immunity to human renal tubular epithelial cell injury (TECs) remains poorly defined. Cells…
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