(Background) Recently graft survival of kidney transplant recipients is longer than before,so it is important to manage arteriosclerosis including calcium(Ca)/phosphorus(P) metabolism.
(Aim)We examined how effective preemptive living donor kidney transplantation(PET) was in Ca/P metabolism early post kidney transplantation.
(Method) This study was a prospective cohort.PET was defined as predialysis and estimated glomerular filtration rate<10 ml/min/m2 ,and non PET as dialysis duration>2 years and urine volume< 100ml/day. Thirty two patients who underwent living donor kidney transplantation from June to October in 2011 at Nagoya Daini Red Cross Hospital in Japan were enrolled.Intact fibroblast growth factor(FGF)23,intact parathyroid hormone(PTH),Ca/P ,and creatinine(Cre) as a serum sample and Cre,Ca and P as a urine sample were meseared before transplantation,1 week(1w), 3 week(3w) and 6 month(6m) after transplantation.
(Result)Patientscharacteristics are shown in Figure 1.
Serum Ca at 6m was higher in nonPET(p<0.05),but not significant difference at 1w and 3w.Serum P at 1w and 3w was much lower in nonPET(p<0.05),but not significant difference at 6m. Serum FGF23 at 1w and 3w was much lower in nonPET(p<0.05),but not significant difference at 6m.Serum PTH at 6m was higher in nonPET(p<0.05),but not significant difference at 1w and 3w.Multivariate analysis showed pretransplant FGF23 was an indepent risk factor for hypophosphatemia at 1w and 3w ,and hypercalcemia at 6m.
(Conclusion)Pretransplant FGF23,not PTH,was the best predict marker for hypophosphatemia at 1w and 3w ,and hypercalcemia at 6m.
To cite this abstract in AMA style:Tsujita M, Yamamoto T, Hiramitsu T, Nanmoku K, Goto N, Inaguma D, Watarai Y, Tominaga Y. Pretransplant FGF23 Titer Predicts Hypercalcemia at 6month Post Transplant Recipients [abstract]. Am J Transplant. 2013; 13 (suppl 5). https://atcmeetingabstracts.com/abstract/pretransplant-fgf23-titer-predicts-hypercalcemia-at-6month-post-transplant-recipients/. Accessed May 6, 2021.
« Back to 2013 American Transplant Congress