ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    Sterile Leukocyturia Predicts Interstitial Fibrosis and Tubular Atrophy in Kidney Allograft Protocol Biopsies

    S. Coelho, O. Bestard, N. Porta, E. Melilli, O. Taco, I. Rivas, J. Grinyo, J. Cruzado

    Nephrology, Hospital Fernando Fonseca, Lisbon, Portugal; Nephrology, Hospital de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain; Biostatistics, UCICEC-CAIBER, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain

    In kidney allograft protocol biopsies the presence of interstitial fibrosis and tubular atrophy (IF/TA) is associated with graft loss. In this study we sought to…
  • 2013 American Transplant Congress

    E-Cad Promotes Liver Tissue Formation in Hepatic Differentiation of Mouse Embryonic Stem Cells through Regulating the Differentiation Progress

    A. Hu, X. He

    Department of Organ Transplantation, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guongdong Province, China

    Objective Until now, the hepatic differentiation of embryonic stem cells (ESCs) usually results in single cell lineage and could not form liver tissues. In this…
  • 2013 American Transplant Congress

    Effects of High Fat Breakfast, Low Fat Breakfast or Fasting on the Absorption of Voclosporin (VCS), The

    L. Aspeslet, D. Freitag, R. Huizinga, S. Ling, P. Mayo, R. Foster

    Isotechnika Pharma Inc., Edmonton, Canada

    Objective:To assess the effects of fasting, consumption of a high-fat breakfast and consumption of a low-fat breakfast on the absorption of VCS, a new calcineurin…
  • 2013 American Transplant Congress

    Late Extra-Hepatic Biliary Strictures after Liver Transplantation: First Evidence of Association with Pre-Existing Donor Specific Antibodies

    S. Loeb, E. Schadde, B. Ruesi-Elsener, P. Dutkowski, C. Pierre Alain, B. Jens

    Department of Surgery and Transplantation, University Hospital Zurich, Swiss HPB and Transplant Center, Zurich, Switzerland

    Late biliary strictures following liver transplantation are a major source of graft loss, and usually attributed to vascular problems. In many cases, however, vascular pathologies…
  • 2013 American Transplant Congress

    Mesenchymal Stromal Cells Promote Bowel Regeneration after Intestinal Transplantation: Myth to Mucosa

    C. Ceresa, F. Dazzi, R. Ramcharan, S. Reddy, E. Fryer, S. Marley, F. Lee, S. Sinha, P. Friend, A. Vaidya

    Oxford Transplant Centre, Churchill Hospital, Oxford, United Kingdom; Stem Cell Biology, Department of Medicine, Imperial College London, London, United Kingdom; Department of Cellular Pathology, John Radcliffe Hospital, Oxford, United Kingdom

    Aim: To report the first case of use of mesenchymal stromal cells (MSCs) to promote mucosal regeneration in an isolated intestinal transplant recipient who had…
  • 2013 American Transplant Congress

    CCR2 Dependent Migration Is Absolutely Required for Myeloid Suppressor Cells To Protect Cell Transplants

    J. Qin, Y. Arakawa, J. Fung, S. Qian, L. Lu

    Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH; General Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH

    Whole organ transplantation gets great success, while the outcomes of cell transplants remain poor, suggesting a critical role of non-parenchymal cells in immune regulation. Through…
  • 2013 American Transplant Congress

    Kidney Transplantation: Pre and Post-Transplant Immunological Evaluation and Outcome of Recipients in Low, Medium, and High Risk of Rejection

    S. Abrahao, R. Oliveira, A. Pereira, F. Junior, M. Maciel, B. Vilela, C. Filho, R. Gontijo, E. Nascimento

    Laboratorio de Histocompatibilidade, Imunogenetica e Imunologia de Transplantes, IMUNOLABTx, Belo Horizonte, Minas Gerais, Brazil; Hospital das Clínicas, Universidade Federal de Minas Gerais, Beloo Horizonte, Minas Gerais, Brazil; MG Transplantes, FHEMIG, Belo Horiznte, Minas Gerais, Brazil; Instituto de Ensino e Pesquisas, Clínica de Transplantes, Santa Casa de Belo Horizonte, Belo Horizonte, Minas Gerais, Brazil

    Specific antibodies (AB) against donor (DSA) have a fundamental role in the mechanism of kidney (K) transplant rejection and represent one of the main barriers…
  • 2013 American Transplant Congress

    Prolonged Cardiac Allograft Survival Due to Treg Expansion in Recipient BAFF-Tg Mice

    M. Saito, G. Zhang, Y. Wang, M. Hu, S. Walters, J. Zhou, A. Sawyer, J. Chapman, S. Grey, S. Alexander

    Centre for Kidney Research, Children's Hospital at Westmead, Sydney, Australia; Centre for Transplant and Renal Research, Westmead Hospital, Sydney, Australia; Gene Therapy & Autoimmunity Group, Immunology and Inflammation Program, Garvan Institute of Medical Research, Sydney, Australia

    Background: B cell activation factor of the TNF family (BAFF) is considered to function as a proinflammatory cytokine. BAFF is crucial for B cell development…
  • 2013 American Transplant Congress

    Induction of Donor Specific Hyporesponsiveness in Kidney Transplantation Using Adoptive Transfer of Ex Vivo Induced Tolerogenic Cells

    I. Koyama, H. Bashuda, K. Seino, K. Kai, T. Murakami, A. Sannomiya, I. Nakajima, S. Fuchinoue, K. Okumura, S. Teraoka

    Tokyo Women's Medical University, Tokyo, Japan; Juntendo University, Tokyo, Japan; Hokkaido University, Sapporo, Japan; International University of Health and Welfare, Atami, Japan

    [Background] Anergic T cells generated ex vivo under conditions of co-stimulatory blockade are reported to have tolerogenic effects. According this finding, we have conducted the…
  • 2013 American Transplant Congress

    Prospective Randomized Trial Aimed To Reduce the Incidence of Cytomegalovirus (CMV) Infection in Kidney Transplant (KT) Recipients, A

    H. Tedesco, C. Felipe, L. Wang, C. Rodrigues, T. Sandes, M. Cristelli, M. Franco, J. Medina-Pestana

    Nephrology Division, Hospital do Rim e Hipertensão, São Paulo, Brazil

    Introduction: CMV infection has been associated with inferior long-term patient and graft survival. This single center prospective study compares the effect of 3 immunosuppressive regimens…
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