2013 American Transplant Congress
Microcirculation Inflammation Is Superior to Peritubular Capillary Basement Membrane Multilayering for Outcome Prediction in Renal Transplant Patients with De Novo Donor-Specific Antibodies
Imperial College NHS Trust, London, United Kingdom; , United Kingdom
In renal transplant patients with de novo donor-specific antibodies (DSA) we compared peritubular capillary basement membrane multilayering (PTCBML) counts with microcirculation inflammation (MI) score to…2013 American Transplant Congress
Acute Rejection on Surveillance Biopsies Is a Predictor of Functional Decline in Kidney Transplants over Long-Term Follow-Up
Background: Identifying specific factors that are predictive of renal allograft functional decline is important toward prolonging graft survival. Few studies have addressed specific histologic diagnoses…2013 American Transplant Congress
Epigenetic Mechanisms Underlying Allograft Rejection: Role of the Histone Acetyltransferase, GCN-5 in T Cell Activation, Proliferation and Cytokine Production
There is currently no literature on the roles of histone acetyltransferases (HATs) in allograft biology, despite the central roles that these enzymes are thought to…2013 American Transplant Congress
Intragraft Gene Expression Profiles of C4d-/DSA+ and C4d-/DSA- Transplant Glomerulopathy Biopsies Compared to Biopsies with Chronic Antibody Mediated Rejection
Montefiore/Einstein Transplant Center, Bronx, NY
Background: We investigated the histopathologic features and gene expression profiles of C4d-/donor-specific anti-HLA antibodies (DSA)+ and C4d-/DSA- transplant glomerulopathy (TGP) biopsies compared to C4d+/DSA+ chronic…2013 American Transplant Congress
Decade of Experience with Deceased Donor Kidney Transplantation in Recipients over Age 75, A
Abdominal Transplant, General Surgery, Wake Forest Baptist Medical Center, Winston Salem, NC
We retrospectively reviewed outcomes in adult patients (pts) 75 years receiving deceased donor kidney transplants (KTs) at our center. Results: We performed 46 KTs in…2013 American Transplant Congress
Anti-ER-TR7 mAb Prevents Tolerogenic Lymph Node Morphogenesis and Overrides Transplant Tolerance
University of Maryland, Baltimore
Background: Transplant tolerance is exquisitely sensitive to changes in secondary lymphoid organ structure and function. Costimulatory blockade plus donor-specific splenocyte transfusion (DST) induces long-term graft…2013 American Transplant Congress
Problems and Pitfalls in Calculation of “True” Treg Numbers Using Assays of Foxp3 TSDR Demethylation in PBMC of Transplant Recipients
FOXP3 is the master transcription factor of CD4+CD25+FOXP3+ T-regulatory (Treg) cells, and demethylation of the Treg-specific demethylation region (TSDR) of FOXP3 is considered a specific…2013 American Transplant Congress
Physical Activity Level Post Kidney Transplantation: Evolution and Impact on Body Composition. Results from the CORPOS Study
Physical activity (PA) level after kidney transplantation (KT) is little studied, although it is an important component of quality of life. Recently, it has also…2013 American Transplant Congress
Intra-Graft Expression of Transcripts for Endothelial Activation and NK Cell Markers, Detected by Real-Time qPCR, Is Associated with the Presence of Donor Specific Antibodies, and Identifies Kidney Transplants at Risk of Failure
Background: Transcriptome analysis by micro-array from kidney transplant biopsy cores has identified genes associated with endothelial activation (ENDAT), and NK cell activity (NK), which are…2013 American Transplant Congress
Transmission of Coccidioidomycosis through Organ Transplantation
OPTN Ad Hoc Diseases Transmission Advisory Committee; United Network for Organ Sharing
BackgroundDonor derived coccidioidomycosis (cocci) has been a significant cause of unexpected morbidity and mortality in transplant recipients. Most cases are reported from OPTN region 5.…
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