Am J Transplant, Volume 3, Suppl 5 Archives - Page 168 of 178 - ATC Abstracts

2013 American Transplant Congress
Early Rehospitalization after Kidney Transplantation: Predictors and Prognosis
M. Nair, E. Lin, A. Pai, M. Harhay, A. Huverserian, A. Mussell, A. Troxel, R. Bloom, M. Levine, P. Abt, J. Shea, P. Reese
University of Pennsylvania, Philadelphia, PA
Early rehospitalization occurs commonly after kidney transplantation (KT). Rehospitalization may identify patients at risk for future adverse outcomes. Methods: We performed a retrospective cohort study…
2013 American Transplant Congress
Dynamic Dual Role of IL-2 Signaling in the Two-Step Differentiation Process of Adaptive Regulatory T Cells, A
Z. Guo, Y. Miyahara, G. Wang, M. Khattar, P. Schroder, X. He, W. Chen, S. Stepkowski
Organ Transplant Center, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Department of Medical Microbiology and Immunology, University of Toledo College of Medcine, Toledo; Diabetes and Endocrinology Research Center, Baylor College of Medicine, Houston; Department of Cardiovascular Surgery, Union Hospital, Huazhong University of Science and Technology, Wuhan, China
Background. Regulatory T (Treg) cells are with potential to induce transplant tolerance. However, the molecular mechanism of the extrathymic generation of adaptive CD4+Foxp3+ regulatory T…
2013 American Transplant Congress
Immune, Inflammatory and Apoptosis Gene Expression in Human Formalin-Fixed Paraffin-Embedded (FFPE) Kidney Biopsies Correlate with Banff Scored Acute Rejection and Reveals Heterogeneous Genetic Subtypes Bearing Common Histological Patterns
P. Ruiz, E. Margolles-Clark, J. Sageshima, G. Ciancio, L. Chen, A. Mattiazi, G. Guerra, W. Kupin, D. Roth, G. Burke
Surgery, University of Miami, Miami, FL; Medicine, University of Miami, Miami, FL
The lack of appropriate in situ biomarkers available to detect acute rejection makes it difficult to optimize anti-rejection therapies for heterogeneous forms of alloreactive processes…
2013 American Transplant Congress
Mesenchymal Stem Cells Control Allo-Reactive CD28- T Cells That Are Unaffected by Belatacept Treatment
A. Engela, C. Baan, N. Litjens, M. Franquesa, M. Betjes, W. Weimar, M. Hoogduijn
Department of Internal Medicine, Section Nephrology and Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
Introduction: CD28/B7 co-stimulation blockade with belatacept is used to prevent allo-reactivity in kidney transplant patients. Cells that lose CD28 during differentiation are not sufficiently controlled…
2013 American Transplant Congress
Microcirculation Injury Associates with Donor-Specific Anti-HLA Antibodies in ABO Incompatible Renal Transplant Patients
H. de Kort, R. Charif, P. Brookes, D. Kanigicherla, E. Santos-Nunez, A. McLean, D. Taube, H. Cook, J. Galliford, C. Roufosse
Imperial College NHS Trust, London, United Kingdom; Royal Infirmary, Manchester, United Kingdom
Detecting antibody-mediated damage in ABO incompatible (ABOi) renal transplants has been hampered by the lack of usefulness of C4d staining. We assessed the relevance of…
2013 American Transplant Congress
Genetic and Pharmacologic Evidence for the Essential Role of the Deubiquitinase, USP7, in Maintaining Foxp3 Expression and Promoting Treg Function
L. Wang, Y. Liu, R. Han, W. Gu, B. Nicholson, W. Hancock
UPenn/CHOP, Philadelphia, PA; Columbia University, New York, NY; Progenra, Malvern, PA
Foxp3 is subjected to multiple post-translational modifications that govern Treg function. E.g. The histone acetyltransferases, p300 and CBP, acetylate Foxp3, increasing its stability and promoting…
2013 American Transplant Congress
Impact of Donor HLA Mismatch Grade on Recipient HLA Locus-Specific Sensitisation in Patients Returning to the Kidney Transplant Waiting List Following a Failed Primary Kidney Allograft
O. Gjorgjimajkoska, C. Taylor, L. Sharples, N. Chatzizacharias, S. Peacock, C. Morgan, E. Bolton, J. Bradley, V. Kosmoliaptsis
Department of Surgery and Tissue Typing Laboratory, University of Cambridge, Cambridge, United Kingdom
Background: The impact of Human Leukocyte Antigen (HLA) matching algorithms on kidney allocation policies in the modern era of immunosuppression is controversial. This study investigated…
2013 American Transplant Congress
1-Year Outcomes of a Prospective, Open Label, Randomized, Controlled Trial of Standard vs Extended-Release Tacrolimus as Maintenance Monotherapy in Kidney Transplantation after Alemtuzumab Induction with Rapid Steroid Withdrawal (TAESR Trial)
A. McLean, K. Chan, J. Galliford, D. Goodall, R. Charif, M. Willicombe, C. Roufosse, T. Cook, D. Taube
Imperial College Kidney & Transplant Centre, Hammersmith Hospital, London, United Kingdom; Imperial Clinical Trials Unit, Imperial College, London, United Kingdom; Department of Medicine, Imperial College, London, United Kingdom
Background: Extended-release (ER, once daily) tacrolimus (Advagraf) has been shown to provide equivalent results to standard-release (SR, twice daily) tacrolimus in several regimens for maintenance…
2013 American Transplant Congress
Proteasome Inhibitor-Related Toxicities in a Prospective Trial of Desensitization
N. Ejaz, R. Alloway, B. Sadaka, A. Shields, B. Abu Jawdeh, F. Paterno, M. Cardi, E. Woodle
U of Cincinnati, Cincinnati; The Christ Hospital, Cincinnati
A large, prospective proteasome inhibitor (PI)-based desensitization (DS) trial was conducted over a 3 year period in which toxicity data was collected prospectively. The purpose…
2013 American Transplant Congress
Aggregate Annual Health Care Expenditures Associated with Lung Transplantation in the United States: 1988-2011
R. Evans
United Network for the Recruitment of Transplantation Professionals, Rochester, MN
No attempt has been made to estimate the aggregate annual health care expenditures associated with lung transplantation in the U.S.The data required for this analysis…