2013 American Transplant Congress
Intragraft Gene Expression Profiles of C4d-/DSA+ and C4d-/DSA- Transplant Glomerulopathy Biopsies Compared to Biopsies with Chronic Antibody Mediated Rejection
Montefiore/Einstein Transplant Center, Bronx, NY
Background: We investigated the histopathologic features and gene expression profiles of C4d-/donor-specific anti-HLA antibodies (DSA)+ and C4d-/DSA- transplant glomerulopathy (TGP) biopsies compared to C4d+/DSA+ chronic…2013 American Transplant Congress
Decade of Experience with Deceased Donor Kidney Transplantation in Recipients over Age 75, A
Abdominal Transplant, General Surgery, Wake Forest Baptist Medical Center, Winston Salem, NC
We retrospectively reviewed outcomes in adult patients (pts) 75 years receiving deceased donor kidney transplants (KTs) at our center. Results: We performed 46 KTs in…2013 American Transplant Congress
Anti-ER-TR7 mAb Prevents Tolerogenic Lymph Node Morphogenesis and Overrides Transplant Tolerance
University of Maryland, Baltimore
Background: Transplant tolerance is exquisitely sensitive to changes in secondary lymphoid organ structure and function. Costimulatory blockade plus donor-specific splenocyte transfusion (DST) induces long-term graft…2013 American Transplant Congress
Problems and Pitfalls in Calculation of “True” Treg Numbers Using Assays of Foxp3 TSDR Demethylation in PBMC of Transplant Recipients
FOXP3 is the master transcription factor of CD4+CD25+FOXP3+ T-regulatory (Treg) cells, and demethylation of the Treg-specific demethylation region (TSDR) of FOXP3 is considered a specific…2013 American Transplant Congress
Physical Activity Level Post Kidney Transplantation: Evolution and Impact on Body Composition. Results from the CORPOS Study
Physical activity (PA) level after kidney transplantation (KT) is little studied, although it is an important component of quality of life. Recently, it has also…2013 American Transplant Congress
Intra-Graft Expression of Transcripts for Endothelial Activation and NK Cell Markers, Detected by Real-Time qPCR, Is Associated with the Presence of Donor Specific Antibodies, and Identifies Kidney Transplants at Risk of Failure
Background: Transcriptome analysis by micro-array from kidney transplant biopsy cores has identified genes associated with endothelial activation (ENDAT), and NK cell activity (NK), which are…2013 American Transplant Congress
Transmission of Coccidioidomycosis through Organ Transplantation
OPTN Ad Hoc Diseases Transmission Advisory Committee; United Network for Organ Sharing
BackgroundDonor derived coccidioidomycosis (cocci) has been a significant cause of unexpected morbidity and mortality in transplant recipients. Most cases are reported from OPTN region 5.…2013 American Transplant Congress
Treatment of Chronic Antibody-Mediated Rejection after Kidney Transplantation: Does Rituximab and Intravenous Globulins Improve Graft Survival?
Background . Chronic antibody-mediated rejection (CAMR) is a major cause of renal graft loss and there is no evidence-based treatment. Patients and methods . All…2013 American Transplant Congress
Interactions of B and T Regulatory Cells in Normal Volunteers and in Tolerant HLA-Identical Kidney Transplant Recipients
Surgery; Comprehensive Transplant Center, Northwestern University, Chicago, IL
Purpose: In an HLA Identical (id) renal transplant (RT) tolerance trial using donor hematopoietic stem cells, alemtuzumab induction, and temporary maintenance immunosuppression (IS), primarily with…2013 American Transplant Congress
Bacteremic Sepsis in Transplantation: Can Antibiotic Duration Be Shortened by the Use of Sequential Procalcitonin and Endotoxin? A Prospective Cohort Study
University of Nebraska Medical Center, Omaha, NE
Introduction: Solid organ transplant patients with bacteremic sepsis are usually treated with antibiotics for 10-21 days. The evidence to support this length of therapy is…
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