2013 American Transplant Congress
B-Cell-Attracting Chemokine-13 (CXCL13) in Human and Murine Kidney Allograft Rejection
Purpose: B-cells play an important role in acute renal allograft rejection. It is known that the B-cell-attracting chemokine 13 (CXCL13), which is expressed by dendritic…2013 American Transplant Congress
Autophagy-Deficient T Cells Are Resistant to Cell Death after Costimulatory Blockade
Nephrology, Mount Sinai School of Medicine, New York, NY
The induction and maintenance of stable transplant tolerance involves both regulatory and deletional mechanisms, the latter of which have been attributed to T cell apoptosis.…2013 American Transplant Congress
Search for New Nephroprotective Strategies in Orthotopic Liver Transplantation
The classical OLT technique (>90% of cases in our centre) leads to increased rates of acute kidney injury (AKI up to 81, 4%). The purpose…2013 American Transplant Congress
Human Microbiota Characterization in the Course of Renal Transplantation
BACKGROUND: The human microbiota comprises all microbes associated with the human body and could play an important role for transplant recipient health. It may serve…2013 American Transplant Congress
Public Survey of Acceptable Financial Incentives for Living Donation: Challenging Assumptions and Reinvigorating the Debate, A
Background. The potential use of financial incentives to increase living kidney donation rates has generated much controversy over the potential for exploitation of and undue…2013 American Transplant Congress
Assessment of Preventable and Non-Preventable Early Rehospitalization Following Kidney Transplantation
University of Pennsylvania, Philadelphia, PA
Early rehospitalization following transplant surgery occurs in 28.5% of kidney transplant (KT) recipients, compared to rates of 10-16% following other abdominal surgeries. Studies of claims…2013 American Transplant Congress
Influence of Recipient Age on Outcomes in Paired Kidney Transplantation
Abdominal Transplant, General Surgery, Wake Forest Baptist Medical Center, Winston Salem, NC
We compared the effect of older recipient age (70 vs <70 yrs) on kidney transplant (KT) outcomes in adult patients (pts) receiving mate kidneys from…2013 American Transplant Congress
Overcoming Hyperacute Rejection of Monkey ABO-Incompatible Renal Transplantation Using a Complement Inhibition-Based Strategy
Background: It has been demonstrated that complement inhibition-based strategy enables renal allograft accommodation and long-term engraftment in donor skin-presensitized monkeys. The effect of the same…2013 American Transplant Congress
CD3 Antibody-Induced Transplant Tolerance Relies on In Situ TGF-Beta and PD-1 Signaling in T Cells
CD3 antibody therapy, successfully used to treat patients with recent onset type 1 diabetes, can restore self-tolerance to autoantigens. We extented these tolerogenic properties to…2013 American Transplant Congress
Pretransplant Donor-Specific HLA-Cw Antibodies and Risk of Antibody-Mediated Rejection
Donor-specific anti-HLA antibodies (DSA) cause acute and chronic antibody-mediated rejection (AMR) and significantly compromise allograft survival. Clinical relevance of antiHLA-Cw antibodies is still unclear with…
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