2013 American Transplant Congress
Microcirculation Injury Associates with Donor-Specific Anti-HLA Antibodies in ABO Incompatible Renal Transplant Patients
Imperial College NHS Trust, London, United Kingdom; Royal Infirmary, Manchester, United Kingdom
Detecting antibody-mediated damage in ABO incompatible (ABOi) renal transplants has been hampered by the lack of usefulness of C4d staining. We assessed the relevance of…2013 American Transplant Congress
Genetic and Pharmacologic Evidence for the Essential Role of the Deubiquitinase, USP7, in Maintaining Foxp3 Expression and Promoting Treg Function
UPenn/CHOP, Philadelphia, PA; Columbia University, New York, NY; Progenra, Malvern, PA
Foxp3 is subjected to multiple post-translational modifications that govern Treg function. E.g. The histone acetyltransferases, p300 and CBP, acetylate Foxp3, increasing its stability and promoting…2013 American Transplant Congress
Impact of Donor HLA Mismatch Grade on Recipient HLA Locus-Specific Sensitisation in Patients Returning to the Kidney Transplant Waiting List Following a Failed Primary Kidney Allograft
Background: The impact of Human Leukocyte Antigen (HLA) matching algorithms on kidney allocation policies in the modern era of immunosuppression is controversial. This study investigated…2013 American Transplant Congress
1-Year Outcomes of a Prospective, Open Label, Randomized, Controlled Trial of Standard vs Extended-Release Tacrolimus as Maintenance Monotherapy in Kidney Transplantation after Alemtuzumab Induction with Rapid Steroid Withdrawal (TAESR Trial)
Background: Extended-release (ER, once daily) tacrolimus (Advagraf) has been shown to provide equivalent results to standard-release (SR, twice daily) tacrolimus in several regimens for maintenance…2013 American Transplant Congress
Proteasome Inhibitor-Related Toxicities in a Prospective Trial of Desensitization
U of Cincinnati, Cincinnati; The Christ Hospital, Cincinnati
A large, prospective proteasome inhibitor (PI)-based desensitization (DS) trial was conducted over a 3 year period in which toxicity data was collected prospectively. The purpose…2013 American Transplant Congress
Aggregate Annual Health Care Expenditures Associated with Lung Transplantation in the United States: 1988-2011
United Network for the Recruitment of Transplantation Professionals, Rochester, MN
No attempt has been made to estimate the aggregate annual health care expenditures associated with lung transplantation in the U.S.The data required for this analysis…2013 American Transplant Congress
Donor Specific Antibody (DSA) Does Not Predict Inflammation, Fibrosis, or C4d Score in 12 Tolerant Pediatric Liver Transplant (LT) Recipients: 5+Year Longitudinal Follow-Up
BACKGROUND ITN029, a multicenter pilot trial (n=20) of immunosuppression withdrawal (ISW) in pediatric recipients of parental living donor LTs, identified 12 tolerant participants (pts). The…2013 American Transplant Congress
Subnormothermic Ex Vivo Liver Perfusion (SNEVLP) Reduces Ischemia/Reperfusion Injury in Livers Retrieved after Cardiac Death
We compared the impact of cold static liver preservation vs subnormothermic ex vivo liver perfusion (SNEVLP) on outcome of DCD pig liver transplantation (LT). Methods:…2013 American Transplant Congress
Long Term Outcomes of Treatment for Vascular Complication Following Living Donor Liver Transplantation: The Efficacy of Stent Placement
Background: Vascular complication after liver transplantation sometimes leads to graft loss. The aims of this study were to evaluate the efficacy of stent placement for…2013 American Transplant Congress
Influence of HLA Class II Donor-Specific Antibodies Present at the Time of Renal Transplantation on Early Graft Outcome, The
Introduction. HLA class II donor-specific antibodies (DSA's) have been associated with transplant glomerulopathy and ultimate graft loss. Despite these data, it is unclear if all…
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