2013 American Transplant Congress
One Year Results of the Effects of Rituximab on Acute Humoral Rejection in Renal Transplantation: RITUX ERAH, a Multicenter Randomized Placebo Controlled Trial
Background: The treatment of acute humoral rejection (AHR) is currently based on the combination of plasmepheresis (PE), intravenous immune globulin (IVIg) and corticosteroids (CS). Patients…2013 American Transplant Congress
Risk Factors for Early Onset of Acute Kidney Injury and Subsequent Development of Chronic Renal Disease after Liver Transplantation
Background. Renal impairement is one of the most common complications following liver transplantation (LT) and it is associated with an increased length of stay in…2013 American Transplant Congress
mTOR, but Not Calcineurin, Inhibition Safeguards Anti-Tumoral CD8 Immunity in Transplant Recipients
The purpose of this study was to investigate the role of mTOR versus calcineurin inhibition in anti-tumoral CD8+ T cell responses in posttransplant malignancy. To…2013 American Transplant Congress
Microcirculation Inflammation Is Superior to Peritubular Capillary Basement Membrane Multilayering for Outcome Prediction in Renal Transplant Patients with De Novo Donor-Specific Antibodies
Imperial College NHS Trust, London, United Kingdom; , United Kingdom
In renal transplant patients with de novo donor-specific antibodies (DSA) we compared peritubular capillary basement membrane multilayering (PTCBML) counts with microcirculation inflammation (MI) score to…2013 American Transplant Congress
Acute Rejection on Surveillance Biopsies Is a Predictor of Functional Decline in Kidney Transplants over Long-Term Follow-Up
Background: Identifying specific factors that are predictive of renal allograft functional decline is important toward prolonging graft survival. Few studies have addressed specific histologic diagnoses…2013 American Transplant Congress
Epigenetic Mechanisms Underlying Allograft Rejection: Role of the Histone Acetyltransferase, GCN-5 in T Cell Activation, Proliferation and Cytokine Production
There is currently no literature on the roles of histone acetyltransferases (HATs) in allograft biology, despite the central roles that these enzymes are thought to…2013 American Transplant Congress
Intragraft Gene Expression Profiles of C4d-/DSA+ and C4d-/DSA- Transplant Glomerulopathy Biopsies Compared to Biopsies with Chronic Antibody Mediated Rejection
Montefiore/Einstein Transplant Center, Bronx, NY
Background: We investigated the histopathologic features and gene expression profiles of C4d-/donor-specific anti-HLA antibodies (DSA)+ and C4d-/DSA- transplant glomerulopathy (TGP) biopsies compared to C4d+/DSA+ chronic…2013 American Transplant Congress
Decade of Experience with Deceased Donor Kidney Transplantation in Recipients over Age 75, A
Abdominal Transplant, General Surgery, Wake Forest Baptist Medical Center, Winston Salem, NC
We retrospectively reviewed outcomes in adult patients (pts) 75 years receiving deceased donor kidney transplants (KTs) at our center. Results: We performed 46 KTs in…2013 American Transplant Congress
Anti-ER-TR7 mAb Prevents Tolerogenic Lymph Node Morphogenesis and Overrides Transplant Tolerance
University of Maryland, Baltimore
Background: Transplant tolerance is exquisitely sensitive to changes in secondary lymphoid organ structure and function. Costimulatory blockade plus donor-specific splenocyte transfusion (DST) induces long-term graft…2013 American Transplant Congress
Problems and Pitfalls in Calculation of “True” Treg Numbers Using Assays of Foxp3 TSDR Demethylation in PBMC of Transplant Recipients
FOXP3 is the master transcription factor of CD4+CD25+FOXP3+ T-regulatory (Treg) cells, and demethylation of the Treg-specific demethylation region (TSDR) of FOXP3 is considered a specific…
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