ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    Common Rejection Module (CRM) across Multiple Transplant Organs Identifies Novel Therapeutics for Treatment of Acute Rejection in Solid Organ Transplantation, A

    S. Roedder, P. Khatri, N. Kimura, K. De Vusser, A. Morgan, Y. Gong, M. Fischbein, R. Robbins, M. Naesens, A. Butte, M. Sarwal

    Transplantation Research BIOMARC Program, California Pacific Medical Center, Sutter Health, San Francisco, CA; Pediatrics, Division of Systems Medicine, Stanford University, Stanford, CA; Cardiothoracic Surgery, Stanford University, Stanford, CA; Nephrology, Leuven University, Leuven, Belgium

    We performed meta-analyses of eight datasets comprising whole genome microarray expression profiles on 236 graft biopsy samples from four types of transplanted organs (kidney, lung,…
  • 2013 American Transplant Congress

    Cardiovascular Disease and Kidney Disease Progression in Kidney Transplant Recipients

    A. John, D. Weiner, M. Carpenter, L. Hunsicker, J. Kusek, M. Pfeffer, S. Solomon, M. Weir, A. Levey

    Tufts Medical Center, Boston, MA; University of North Carolina, Chapel Hill, NC; University of Iowa, Iowa City, IA; University of Maryland, Baltimore, MD; Brigham and Women's Hospital, Boston, MA; National Institute of Health, Bethesda, MD

    Background: Kidney transplant recipients have a high prevalence of cardiovascular disease (CVD) and CVD risk factors, such that CVD is the leading cause of mortality.…
  • 2013 American Transplant Congress

    For Cause Renal Biopsies Are Heterogeneous Irrespective of Clinical Presentation

    A. Cherukuri, S. Balasubramanian, P. Prasad, C. Angel, A. Lewington, C. Newstead, B. Clark, R. Baker

    St.James's University Hospital, Leeds, United Kingdom

    Deteriorating renal function either evidenced by a rise in serum creatinine or proteinuria remains the most important indication for a late transplant biopsy. Over the…
  • 2013 American Transplant Congress

    Age Disparities in Discussions about Kidney Transplantation among Dialysis Patients

    M. Salter, M. McAdams DeMarco, A. Law, B. Jaar, R. Parekh, D. Segev

    Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD; Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD; Division of Nephrology, Johns Hopkins School of Medicine, Baltimore, MD; Division of Nephrology, University of Toronto, Toronto, Canada

    BACKGROUND: Older patients show improved survival and quality of life following kidney transplantation (KT) compared to those who remain on dialysis, yet referral for KT…
  • 2013 American Transplant Congress

    Human Insulinoma Expression of E2F Reveals a Role in Beta-Cell Proliferation and Quiescence

    B. Rady, Y. Chen, P. Vaca Sanchez, Q. Wang, Y. Wang, J. Oberholzer

    Surgery - Transplant, University of Illinois at Chicago, Chicago, IL

    Reversal of diabetes in patients through islet cell transplant is quickly becoming a reality. However, cadaver organ donations, the current source of islets for transplant,…
  • 2013 American Transplant Congress

    Six Minute Walk Distance, Sarcopenia and Cardiopulmonary Assessment in Candidates for Liver Transplantation

    A. Yadav, Carpenter, Chang, Silva, Aqel, Byrne, Douglas, Vargas, Carey

    Transplant Hepatology, Mayo Clinic, Pheonix; Radiology, Mayo Clinic, Pheonix; Biostatistics, Mayo Clinic, Pheonix

    Evaluation for liver transplantation (LT) focuses on organ-specific testing intended to determine a candidate’s fitness for transplantation. However, simple tests of global physical function may…
  • 2013 American Transplant Congress

    Efficient Identification of All Grades of Antibody Mediated Rejection (AMR) and Mixed Rejection with a Unique Immunohistochemical Panel in Heart Transplant Patients

    P. Ruiz, S. Chaparro, E. Bauerlein, T. Bueno, B. Bednar, P. Rusconi, J. Jimenez, S. Pham

    Surgery, University of Miami, Miami, FL; Medicine, University of Miami, Miami, FL; Pediatrics, University of Miami, Miami, FL

    Antibody Mediated Rejection (AMR) following heart transplantation is increasingly recognized as a substantial complication that increases risk for graft failure, vasculopathy, and decreased recipient survival.…
  • 2013 American Transplant Congress

    Pulmonary Vascular Hemodynamics Improvement with Left Ventricular Assist Devices Unloading Is Sustained after Heart Transplantation

    A. Saidi, O. Wever-Pinzon, J. Stehlik, E. Gilbert, R. Alharethi, C. Selzman, B. Reid, D. Budge, A. Kfoury, F. Bader

    UTAH Cardiac Transplant Program, Salt Lake City, UT

    Background:Pulmonary hypertension (PHT) is frequently seen in patients with advanced heart failure (HF) awaiting heart transplantation (HTx). Severe PHT is a contraindication for HTx. Both…
  • 2013 American Transplant Congress

    Long-Term Persistence of Recipient MHC Class-II Antigen Following Allogeneic Bone Marrow Transplantation

    T. Brennan, L. Lin, Y. Yang

    Surgery, Duke University, Durham, NC; Medicine and Immunology, Duke University, Durham, NC

    Background: Following allogeneic bone marrow transplantation there is rapid replacement of host antigen presenting cells with donor antigen presenting cells. This has important implications of…
  • 2013 American Transplant Congress

    Sustained Expression of CD39 Protects Acutely from Renal IRI but Promotes Fibrosis

    V. Roberts, B. Lu, P. Cowan, S. Robson, K. Dwyer

    Immunology Research Centre, St Vincent's Hospital, Melbourne, Victoria, Australia; University of Melbourne, Melbourne, Victoria, Australia; Beth Israel Deaconess Medical Centre, Harvard Medical School, Boston, MA

    Background: The adenosinergic axis is involved in renal ischemia reperfusion injury (IRI) and the generation of adenosine by the action of CD39 and CD73 is…
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