2013 American Transplant Congress
2B4 Induced by Selective CD28 Blockade Functionally Regulates Alloreactive Memory CD8+ T Cell Responses
Emory Transplant Center, Emory University, Atlanta, GA; Bristol-Myers Squibb, Princeton, NJ
Studies in both murine and NHP models have shown that CTLA-4Ig-resistant rejection is mediated by CD8+ T cells, particularly memory CD8+ T cells. Because CTLA-4…2013 American Transplant Congress
Bone Marrow and Adipose Tissue Derived Mesenchymal Stem Cells Induce HLA-Specific Lysis by CD8+ T Cells
IntroductionMesenchymal Stem Cells (MSC) are an interesting cell therapy for clinical organ transplantation and are usually isolated from bone marrow (BM-MSC) or adipose tissue (A-MSC)…2013 American Transplant Congress
Tuberculosis in Kidney Transplant – 10 Years Experience
Nephrology Division, Hospital do Rim e Hipertensão, Sao Paulo, Brazil
Introduction: Tuberculosis infection (TB) increases morbidity and mortality after kidney transplantation (TX) and poses diagnostic and therapeutic challenges. The incidence of TB among solid organ…2013 American Transplant Congress
Influence of Recipient Cytochrome P450 3A5 Polymorphism on the Metabolism of Advagraf Administered De Novo after Renal Transplantation
Advagraf (Adv), a prolonged release formulation of tacrolimus (tac), allows once-a-day administration and improves medication adherence.Patients (pts) possessing at least one CYP3A5*1 allele have an…2013 American Transplant Congress
HLA Antibody Increase Associated with Cardiac Surgery
Increases in titer or de novo production of HLA antibody are potential sequelae of pregnancy, transfusion, or transplantation. It has also been reported that pro-inflammatory…2013 American Transplant Congress
Age and Antimetabolites: Appropriate Candidate Selection Drives Success
Pharmacy, Barnes-Jewish Hospital, St. Louis, MO; Medicine, Washington University, St. Louis, MO
Background:Early studies comparing mycophenolate (MMF) to azathioprine (AZA) post-renal transplant demonstrated superiority of MMF over AZA for the prevention of acute rejection (AR), with no…2013 American Transplant Congress
Donor Factors Similarly Impact Survival Outcome after LT in HCC and Non-HCC Patients
Introduction: Many have advocated the preferential use of high risk allografts for hepatocellular carcinoma (HCC) patients undergoing liver transplantation (LT). HCC patients tend to have…2013 American Transplant Congress
Glycemic Control Significantly Improves Graft & Patient Survival Following Liver Transplant for Hepatitis C
Pharmacy, MUSC, Charleston; Transplant, MUSC, Charleston, SC
Background: Hepatitis C (HCV) is the leading indication for liver transplant in the US. HCV recurrence after transplant is universal and metabolic abnormalities are common…2013 American Transplant Congress
Urinary Metabolomic Pattern Varies over Time and May Be Different in Patients Receiving Cyclosporine or Tacrolimus
EA4245, Université François Rabelais, Tours, France
The tools currently available for clinical monitoring of kidney graft dysfunction are not optimal. Metabolomics is a post-genomic application for analysis of low-molecular weight compounds,…2013 American Transplant Congress
Pre-Transplant Immunologic Risk Assessment and Immune Monitoring of Kidney Transplant Recipients with Pre-Transplant Donor-Specific Anti-HLA Antibodies
Montefiore-Einstein Center for Transplantation, Bronx, NY
Background: We aimed to investigate the importance of pre-transplant immunologic risk assessment of kidney transplant recipients with donor-specific anti-HLA antibodies (DSA) and immune monitoring of…
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