ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Does Length of Hospital Stay and Hospital-Wide Incidence Have an Impact on Clostridium Difficile Infection (CDI) in Organ Transplant Recipients?

J. Deyo, J. Huang, M. Wheeler, R. Lee, T. Zeynep, R. Dupuis, T. Kozlowski

University of North Carolina, Chapel Hill

Meeting: 2013 American Transplant Congress

Abstract number: B1050

Related Abstracts
  • Variability in Incidence of Clostridium difficile Infections and Associated Mortality Among Solid Organ Transplant Recipients
  • Predictors of Clostridium Difficile Infection in Liver Transplant Recipients: A 10 Year Single-Center Cohort Study

Several risk factors contributing to CDI have been identified in organ transplant recipients (Txs)(Transplantation 2012; 93:1051-57). Among these factors is hospital length of stay (LOS). Hospital-wide incidence may also be important. We examined whether reduced LOS and hospital incidence would have an impact on the incidence of CDI in Txs. Methods. Data on kidney (K), liver (Lv), lungs (Lg) and heart (H) Txs were collected from 2005 to 2011 from a single center. UNC hospital database was analyzed for incidence of CDI for all non-Tx and Tx patients. All Txs received induction with SoluMedrol. Some H and L received induction with Basiliximab. K Txs were induced with Campath or Thymoglobulin. Maintenance therapy consisted of tacrolimus & MMF. Maintenance with prednisone was given to patients when T-cell depletion therapy was not administered. Results are reported as mean (standard error). Student’s T-test was used to determine significance (GraphPad V5.0d). Results. From 2005 to 2011, 872 Tx were performed, 414 K, 297 Lv, 79 Lg and 82 H. Incidence of Hospital-wide CDI was stable in 2005-9, at rate of 0.31 to 0.28 per 1000 pts days (d). In 2010 to 2011, it increased from 0.56 to 0.83, respectively (Fig. 1). Incidence of CDI in Txs was: total 4.2%, K 2.4%, Lv 5.4%, Lg 3.8% and H 4.8% (respective n= 10, 16, 3 & 4). Annual CDI distribution was as in Fig. 1. LOS after Tx was different for each organ group. After 2009 there was a shorter LOS in K and Lv but not in Lg or H groups. K LOS was reduced from 10.3±0.7 to 5±0.3 d in 2005-8 when compared to 2009-11. In Lv, LOS was reduced from 28.9± 2.5 to 15.9±1.8 d (K & Lv p<0.001). Lg and H LOS was 35.7±5.1 and 35.5±5.9 d (ns) respectively. LOS for all Txs in 2005-8 was 21.4 vs. 14.7 d in 2009-11 (p<0.001). None of the Txs required colectomy.

Conclusion. Despite a reduction in LOS in the majority of organ Txs, the number of CDI cases in the Tx population has increased similar to the institution’s trend in non-Tx cases (Fig. 1). Minimization of CDI incidence among the transplant population appears to depend also on local institutional control of CDI.

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Deyo J, Huang J, Wheeler M, Lee R, Zeynep T, Dupuis R, Kozlowski T. Does Length of Hospital Stay and Hospital-Wide Incidence Have an Impact on Clostridium Difficile Infection (CDI) in Organ Transplant Recipients? [abstract]. Am J Transplant. 2013; 13 (suppl 5). https://atcmeetingabstracts.com/abstract/does-length-of-hospital-stay-and-hospital-wide-incidence-have-an-impact-on-clostridium-difficile-infection-cdi-in-organ-transplant-recipients/. Accessed January 25, 2021.

« Back to 2013 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Live Related Kidney Transplant Experience in Abuja, Nigeria – First Eight Cases Ever.
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Live Related Kidney Transplant Experience in Abuja, Nigeria – First Eight Cases Ever.
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.