2013 American Transplant Congress
Viral Determinants of Pathogen Induced Alloantibody Production
Emory Transplant Center, Atlanta
Background: The appearance of alloantibody can initiate the onset of rapid and destructive antibody-mediated rejection (AMR) or have no demonstrable acute effects. The factors determining…2013 American Transplant Congress
CMV Serostatus Correlation with Early Kidney Allograft Transcriptome Change in the GOCAR Cohort
Identifying transcriptional change in renal allografts infected with Cytomegalovirus (CMV) may be important in understanding CMV effects on graft rejection and injury.We examined transcriptional profiles…2013 American Transplant Congress
Late Antibody-Mediated Rejection (AMR) after Kidney Transplantation
INTRODUCTION: Late AMR can develop at any time post kidney transplantation and represents a major challenge.OBJECTIVE: To characterize a series of kidney transplant recipients with…2013 American Transplant Congress
Bortezomib Impacts T-Cell Signaling and Regulatory Pathways
Med. Univ South Carolina, Charleston; Cleveland Clinic, Cleveland; Emory University, Atlanta
Introduction/ Aims: Bortezomib (PS-341), a selective 26S proteasome inhibitor has been used to treat antibody mediated rejection (AMR) among allograft recipients. The efficacy of Bortezomib…2013 American Transplant Congress
Outcomes in Lung Transplantation: The RIFLE Classification Optimizes the Predictive Utility of Post-Transplant Acute Kidney Injury as a Determinant of Early and Late Outcomes
The purpose of this study is to compare two methods of classifying acute kidney injury (AKI), the Risk, Injury, Failure, Loss, End stage (RIFLE) and…2013 American Transplant Congress
Validating the Microarray Test for Antibody-Mediated Rejection in a Prospective Trial: The INTERCOM Study
We previously developed a microarray-based test for antibody-mediated rejection (ABMR) in biopsies from renal transplants. To validate it, we undertook the INTERCOM study, a prospective…2013 American Transplant Congress
Cytokine Measurement by High-Sensitivity Milliplex Assay in Cell Suspensions Obtained during Usual Kidney Allograft Biopsies
Division of Nephrology, University of Washington, Seattle, WA
PURPOSE: The purpose of the study was to determine if cytokines could be measured from the supernatant of kidney biopsy cell suspensions and if measured…2013 American Transplant Congress
Alloantibody-Induced C4d Deposition, without Activation of Distal Complement Effectors C5a and C5b-9, Is Not Associated with Kidney Allograft Injury or Accommodation in Mice
University of Alberta, Edmonton, Canada
Complement split product C4d deposition in human organ transplants is a biomarker of classical complement activation triggered by antibody binding to donor antigens, but this…2013 American Transplant Congress
Sitagliptin, DPP- IV Inhibitor, Protects Against Tacrolimus-Induced Diabetes in Rats
The pathogenesis of post-transplant diabetes mellitus is thought to be partly related to the direct toxic effect of tacrolimus on pancreas and the resultant decrease…2013 American Transplant Congress
Splenic Artery Embolization in Liver Transplantation: A Single Center 5 Year Experience
Background:Severe portal hyperperfusion after liver transplantation has been shown to cause intrahepatic arterial vasoconstriction secondary to increased washout of adenosine (hepatic artery buffer response). Furthermore,…
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