2013 American Transplant Congress
Challenges in Safety Managing the Pain in Living Liver Donors
BACKGROUND: Living Liver Donation (LD) is a highly complex major surgical procedure associated with pain. However, managing pain after LD is difficult, as opioid pharmacokinetics…2013 American Transplant Congress
Esophageal Eosinophilia after Intestinal Transplantation
Transplantation, MedStar Gerogetown University Hospital, Washington, DC
Background: The prevalence of eosinophilic esophagitis (EoE) has been increasing, with estimates up to 0.1% of children. We examined esophageal eosinophilia in children after intestinal…2013 American Transplant Congress
Human Regulatory B Cells (BRegs) Are Characterised by Both IL-10 and TNF-α Expression and Are Reduced in Numbers with Altered Function in Renal Transplant Recipients with Immunological Graft Injury
St.James's University Hospital, Leeds, United Kingdom; UCL, London, United Kingdom; UPMC, Pittsburgh
Human Bregs are defined by their ability to express IL-10 and suppress T cells in vitro. We noted that putative Breg subsets also produce pro-inflammatory…2013 American Transplant Congress
Anti-CD3 Accelerated Diabetes in Transgenic Non-Obese Diabetic (NOD) Mice Expressing miRNA Decoy Sequence(s)
Medicine, SUNY at Buffalo; Surgery, SUNY, University at Buffalo, Buffalo, NY
Microinhibitory RNAs (miRNAs) are short sequences that regulate post-transcriptional mRNA and protein expression. miRNA decoy genes alter gene expression by interfering with miRNA binding to…2013 American Transplant Congress
All-Trans Retinoic Acid Promotes the Development of Inducible Nitric Oxide Synthase Producing Dendritic Cells with T Cell Suppressive Function
Hepatic stellate cells (HSCs) have potent immunoregulatory properties and have been shown to induce myeloid cells with suppressive function, which contribute to liver transplantation tolerance.…2013 American Transplant Congress
Systematic Approach Successfully Increases Kidney Transplantation
Organ Donation Services, LifeCenter Northwest OPO, Bellevue, WA
Purpose: Evaluate the impact of a systematic, disciplined approach to increasing kidney transplantation, including clear goals, measurement system, integration of organ procurement organization (OPO) with…2013 American Transplant Congress
Immunosuppressive Property of Liver Sinusoidal Endothelial Cells Is Impaired in Small-for-Size Grafts and Restored by Attenuating Portal Hypertension, The
Department of Surgery, Hiroshima University, hiroshima, Japan
Background:We have previously shown that the accelerated anti-donor immune response is related to the portal hypertension (PH) that develops after living-donor liver transplantation (LDLT), especially…2013 American Transplant Congress
Telaprevir Based Combination Therapy for the Treatment of Recurrent HCV in Liver Transplant Recipients: Promising Early Results, Late Disappointment
Department of Surgery, Division of Transplant Surgery, NYU Langone Medical Center, New York, NY
Background:HCV recurrence is virtually universal in viremic patients at the time of transplant. Long term patient and graft survival is inferior in HCV patients unless…2013 American Transplant Congress
Follow-Up Reporting for Living Kidney Donors
UNOS, Richmond, VA; U of Pittsburgh, Pittsburgh, PA; U of Iowa, Iowa City, IA
Follow-up reporting for living kidney donors (LKDs) increases knowledge of short-term risks of donation. Anecdotal evidence suggests that low reporting rates are due to LKDs…2013 American Transplant Congress
miRNA Signature Associated with Induced Tolerance in Liver Allografts, The
Department of Surgery/Division of Abdominal Transplantation, Stanford University, Stanford, CA
Although the liver is less immunogenic than other solid organs, most liver transplant recipients receive lifelong immunosuppression. A subset of liver recipients may be operationally…
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