Influence of Organ Retrieval Team on Mid-Term Outcome of Lung Transplantation
Department of Cardiothoracic Transplantation &
Mechanical Support, Royal Brompton and Harefield NHS Trust, Harefield Hospital, London, United Kingdom
Meeting: 2013 American Transplant Congress
Abstract number: B905
Purpose Due to a zonal organ allocation scheme introduced in United Kingdom, organ retrieval is performed frequently by different centers. This study evaluates the influence of the retrieval allocation system on lung transplant outcome in a single institution.
Methods Retrospective analysis of all lung transplantations (LTx) performed between 01.2007 and 09.2012. Outcomes in recipients receiving lungs retrieved by the zonal team (ZT) were compared with those retrieved by non-zonal teams(NZT).
Results Out of a total 2662 offers received, n=237 LTx were performed. 1 LTx has been excluded due to loss of data. Lungs from n= 146 donors (61.8%) were procured by ZT vs. 90 donors (38.2%) procured by NZT
The donor characteristics (Age, X-ray, bronchoscopy, duration of mechanical ventilation and smoking history) were comparable in both groups. Pre-retrieval donor PaO2/FiO2 ratio in ZT group was higher (442.5±90 vs. 405±105 mmHg), p=0.009. Donation after cardiac death was more frequent in ZT group vs. NZT group (24.7% vs. 10%), p=0.005.
ZT | NZT | p value | |
Duration of mechanical ventilation-hours | 38 (20;228) | 36 (14;350) | 0.67 |
PaO2/FiO2 ratio-24h | 337±112 | 347±102 | 0.50 |
PaO2/FiO2 ratio-48h | 355±115 | 340±107 | 0.36 |
Intensive care unit stay-days | 5.5 (3;24) | 6 (3;20) | 0.81 |
Hospital stay-days | 35 (23;55) | 33 (22;50) | 0.81 |
Bronchiolitis obliterans syndrome (BOS) was developed in 14.6% in ZT group vs. 19.7% in NZT group (p=0.34) There was a trend towards later onset of BOS in ZT group (652±418vs.446±183 days) (p=0.073).
There was no difference in survival between the groups: ZT vs. NZT 84.3 vs. 85.6 % in 1 year and 71.5 vs. 73.5 % in 3 years; Log rank test p=0.66
Conclusion Lung procurement by other center team along with zonal organ allocation scheme has not any influence on early and mid-term outcome of lung transplantation in our center.
To cite this abstract in AMA style:
Sáez DGarcía, Sabashnikov A, Zych B, Mohite P, Moza A, Robertis FDe, Bahrami T, Amrani M, Carby M, Reed A, Simon A. Influence of Organ Retrieval Team on Mid-Term Outcome of Lung Transplantation [abstract]. Am J Transplant. 2013; 13 (suppl 5). https://atcmeetingabstracts.com/abstract/influence-of-organ-retrieval-team-on-mid-term-outcome-of-lung-transplantation/. Accessed December 5, 2024.« Back to 2013 American Transplant Congress