2013 American Transplant Congress
Safety Issues Identified by Proactive Liver Transplant Safety Debriefing
BACKGROUND: Transplantation and, in particular, living donor liver transplantation (LDLT), involves complex systems and process of care that are particularly susceptible to medical errors and…2013 American Transplant Congress
NKp46 Expression Accelerates the Formation of the NK Cell Lytic Immune Synapse
Natural killer cells play an important role in first-line defense against tumor and virus-infected cells. Studies suggest NK cells have a dichotomous role in transplantation…2013 American Transplant Congress
Targeting Inositol-Requiring Enzyme 1α in Prevention of Donor Specific Antibody (DSA) Mediated Rejection
Introduction: Inositol-requiring enzyme 1Α (IRE1Α), an endoplasmic reticulum-located transmembrane protein kinase, is the activator of transcription factor X-box-binding protein 1 (XBP1) that is required for…2013 American Transplant Congress
Simultaneous Pancreas-Kidney Transplantation in Patients with End-Stage Nephropathy Due to Type 2 Diabetes Mellitus Gives Better Results When Compared to Kidney Transplants Alone
Objective: SPK in type 2 diabetes (T2DM) is performed by a few centers in selected patients. The purpose of the study was to compare patient…2013 American Transplant Congress
Modified Technique of Auxiliary Partial Liver Transplantation in Rat for the Study of Liver Regeneration and Tissue Engineering In Vivo, A
Background:Organ engineering and regenerative medicine using decellularized liver scaffolds offer a promising solution to organ shortage. Auxiliary partial liver transplantation (APLT) in rat is considered…2013 American Transplant Congress
Different Effects of mTOR Inhibitor VS CN Inhibitor on Human B Cells Proliferations and Activation Markers
Background: Humoral immunity is increasingly recognized as an important factor in promoting transplant rejection. However, it is not well known how commonly used immunosuppressive drugs…2013 American Transplant Congress
Human Regulatory B Cells (BRegs) Are Characterised by Both IL-10 and TNF-α Expression and Are Reduced in Numbers with Altered Function in Renal Transplant Recipients with Immunological Graft Injury
St.James's University Hospital, Leeds, United Kingdom; UCL, London, United Kingdom; UPMC, Pittsburgh
Human Bregs are defined by their ability to express IL-10 and suppress T cells in vitro. We noted that putative Breg subsets also produce pro-inflammatory…2013 American Transplant Congress
Anti-CD3 Accelerated Diabetes in Transgenic Non-Obese Diabetic (NOD) Mice Expressing miRNA Decoy Sequence(s)
Medicine, SUNY at Buffalo; Surgery, SUNY, University at Buffalo, Buffalo, NY
Microinhibitory RNAs (miRNAs) are short sequences that regulate post-transcriptional mRNA and protein expression. miRNA decoy genes alter gene expression by interfering with miRNA binding to…2013 American Transplant Congress
All-Trans Retinoic Acid Promotes the Development of Inducible Nitric Oxide Synthase Producing Dendritic Cells with T Cell Suppressive Function
Hepatic stellate cells (HSCs) have potent immunoregulatory properties and have been shown to induce myeloid cells with suppressive function, which contribute to liver transplantation tolerance.…2013 American Transplant Congress
Systematic Approach Successfully Increases Kidney Transplantation
Organ Donation Services, LifeCenter Northwest OPO, Bellevue, WA
Purpose: Evaluate the impact of a systematic, disciplined approach to increasing kidney transplantation, including clear goals, measurement system, integration of organ procurement organization (OPO) with…
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