Am J Transplant, Volume 22, Suppl 3 Archives - Page 95 of 190 - ATC Abstracts

2022 American Transplant Congress
Single Cell RNA Sequencing Identifies Primarily Terminal Effector and Exhausted CD8⁺T Cells in Chronically Rejected Human Kidney Allografts
S. G. Yi¹, D. Zou¹, Y. Dai², Z. Zhao², W. Chen¹, A. Gaber¹
¹Department of Surgery, Houston Methodist Hospital, Houston, TX, ²School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX
*Purpose: Chronic renal allograft rejection often leads to irreversible damage, despite intensification of immunosuppression (ISN). T cell phenotypes in this clinical setting are not well…
2022 American Transplant Congress
Ex Vivo Liver Resection and Autotransplantation – Should It Be Used More Frequently?
J. Weiner¹, A. Griesemer¹, A. Hemming², D. Levi³, T. Beduschi⁴, R. Matsumoto¹, A. Mathur¹, J. Emond¹, T. Kato¹
¹Columbia University Irving Medical Center, New York, NY, ²University of Iowa, Iowa City, IA, ³Atrium Health, Charlotte, NC, ⁴University of Florida, Gainesville, FL
*Purpose: Ex vivo liver resection expands the limits of resectability for advanced liver tumors but remains underutilized due to concerns about technical complexity and vascular…
2022 American Transplant Congress
Combined Heart-Liver Transplantation for Failing Fontan Physiology: A Large Single Center Comparative Analysis
C. J. Rosenthal¹, D. Noguchi¹, J. A. Aboulhosn², G. S. Van Arsdell³, A. Nsair⁴, M. Ha¹, L. Reardon², G. Lluri⁴, J. P. Lin⁴, S. Saab¹, A. Baird¹, R. S. Venick¹, D. G. Farmer¹, F. M. Kaldas¹
¹Liver and Pancreas Transplant Center, UCLA, Los Angeles, CA, ²Ahmanson/UCLA Adult Congenital Heart Disease Center, UCLA, Los Angeles, CA, ³Cardiac Surgery, UCLA, Los Angeles, CA, ⁴Cardiology, UCLA, Los Angeles, CA
*Purpose: The rate of combined heart-liver transplantation (HLT) has tripled in the last decade, and continues to rise along with the number of patients with…
2022 American Transplant Congress
Better Antibody Response After a Dose of Ad.26.cov2.s vs MRNA Vaccines in Seronegative Transplant Recipients After 2-Dose MRNA Vaccination
J. L. Alejo¹, T. Chiang¹, J. Mitchell¹, A. Abedon¹, L. Thomas¹, A. Chang¹, S. Bae¹, R. Avery¹, A. Tobian¹, A. Massie¹, M. Levan¹, D. Warren¹, J. Garonzik-Wang², D. Segev¹, W. Werbel¹
¹JHU, Baltimore, MD, ²U of Wisconsin, Madison, WI
*Purpose: To compare antibody response to a third dose (D3) of SARS-CoV-2 vaccine in solid organ transplant recipients (SOTRs) with negative or low-positive antibody levels…
2022 American Transplant Congress
Allograft TLR9 is Required for Endogenous Donor-Reactive Memory CD8 T Cell Activation in High-Risk Cardiac Allografts to Mediate CTLA-4Ig Resistant Graft Rejection
E. H. Koritzinsky, D. Ueda, H. Tsuda, S. Miyari, R. L. Fairchild
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Prolonged allograft cold ischemic storage (CIS) and subsequent increased ischemia-reperfusion injury (IRI) following solid organ transplant act through innate immune pathways that promote early…
2022 American Transplant Congress
Induction Immunosuppression in ABO-Incompatible Liver Transplant Recipients
S. Shaikh¹, I. Hasan¹, N. Kaur²
¹Keck Medicine of USC, Los Angeles, CA, ²Keck School of Medicine, Los Angeles, CA
*Purpose: ABO-incompatible (ABO-i) liver transplantation (LT) has been associated with an increased risk of AMR, as well as poor patient and graft survival. With advances…
2022 American Transplant Congress
A New Algorithm Combining Donor Derived Cell-Free DNA Fraction and Quantity to Detect Kidney Transplant Rejection Using Molecular Diagnoses and Histology
P. F. Halloran¹, J. Reeve¹, K. S. Madill-Thomsen¹, N. Kaur², E. Ahmed², N. Al Haj Baddar², Z. Demko², N. Liang², R. K. Swenerton², B. G. Zimmermann², P. Van Hummelen², A. Prewett², H. Tabriziani², P. Gauthier², P. R. Billings²
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²Natera, Inc., Austin, TX
*Purpose: Donor derived cell-free DNA (dd-cfDNA) has been shown to be associated with allograft rejection, both histological and molecular (JASN, in press). Clinically available dd-cfDNA…
2022 American Transplant Congress
Experience with Covid-19 Infection and Vaccination in Combined Kidney/HSCT Recipients
M. Gibson¹, D. Belshe¹, G. Gregory¹, S. Tanna¹, M. Ison¹, S. Ildstad², J. R. Leventhal¹
¹Northwestern University, Chicago, IL, ²University of Louisville, Louisville, KY
*Purpose: Kidney transplant(KTx) recipients are at increased risk of COVID-19 related complications. KTx pts who have undergone therapy to induce tolerance are a unique cohort…
2022 American Transplant Congress
Gm2a Regulates Memory Cd8⁺ T Cell Activation and Differentiation
K. P. Tong¹, K. M. Baecher², C. R. Hartigan¹, M. Ford³
¹Emory University Transplant Center, Emory University, Atlanta, GA, ²Department of Surgery, Emory University, Atlanta, GA, ³Emory University, Atlanta, GA
*Purpose: In a clinical trial, patients who underwent kidney transplantation and were subsequently stable off tacrolimus immunosuppression exhibited increased Gm2a transcript in PBMC relative to…
2022 American Transplant Congress
When Pancreata Fly: Excellent Results from Long Distance Imported Pancreas Allografts
N. Owen-Simon, G. Dube, P. Sandoval, L. Ratner, K. McCune
Department of Surgery, Columbia University College of Physicians and Surgeons, New York, NY
*Purpose: To address long waitlist times and increase pancreas transplantation in a competitive donor service area, our center has adopted a protocol for long distance…