Am J Transplant, Volume 22, Suppl 3 Archives - Page 94 of 190 - ATC Abstracts

2022 American Transplant Congress
Conversion to Everolimus-Based Immunosuppression Regimen with Calcineurin Inhibitor Reduction Ameliorates Histological Damage in Kidney Transplant Recipients with Calcineurin Inhibitor-Induced Nephrotoxicity
K. Hotta, N. Iwahara, T. Tanabe, N. Shinohara
Hokkaido University Hospital, Sapporo, Japan
*Purpose: In the last two decades, the short-term results for kidney transplantation (KTX) have improved owing to the use of calcineurin inhibitors (CNIs). However, long-term…
2022 American Transplant Congress
Effect of Covid-19 Diagnosis on Organ Donation and Transplantation
L. Baetje¹, A. Cheng¹, S. Sander², L. Markham², M. Ott², J. Finn², A. Wee³, K. Dyer⁴, A. Atluri¹, D. Jahandar¹, M. Moncure⁴
¹University of Missouri - Kansas City School of Medicine, Kansas City, MO, ²Midwest Transplant Network, Westwood, KS, ³Transplantation Center, Cleveland Clinic, Cleveland, OH, ⁴University Health Kansas City, Kansas City, MO
*Purpose: The coronavirus disease 2019 (COVID-19) pandemic has challenged many aspects of healthcare, including organ donation and transplantation. The purpose of this study is to…
2022 American Transplant Congress
Cold Pulsatile Perfusion Preservation of Deceased Donor Kidneys Did Not Improve Delayed Graft Function Rates in Most Transplants Due to Longer Cold Ischemia Times Offsetting Much of the Benefit, Analysis of SRTR Database
D. S. Keith, E. Lessmann
Kidney Transplant, Ascension Sacred Heart Hospital, Pensacola, FL
*Purpose: To determine the impact of cold pulsatile perfusion preservation (CPPP) on delayed graft function (DGF) in a national cohort of US kidney transplants as…
2022 American Transplant Congress
Management of Brain-Dead Organ Donors by a Dedicated ICU Team Improves Organ Yield
G. L. Piper¹, B. E. Sullivan¹, G. Boulton¹, T. C. Lewis¹, J. Pavone¹, C. Ezzell², D. E. Smith III³, L. Angel¹, N. Moazami³, R. Montgomery¹
¹NYU Langone Transplant Institute, New York, NY, ²LiveOnNY, New York, NY, ³Cardiothoracic Surgery, NYU Langone Health, New York, NY
*Purpose: Management of brain-dead (BD) donors can be challenging in hospitals with limited ICU bed availability, lack of accessible diagnostic capabilities, and a culture that…
2022 American Transplant Congress
Prediction of Delayed Graft Function After Deceased Donor Kidney Transplantation Using Machine Learning and Sequential Donor Data
J. Sageshima¹, J. Yu¹, H. Lala Gul¹, F. De Leon¹, N. Goussous¹, N. Mineyev¹, P. Than¹, K. Jen², R. Perez¹
¹Surgery, University of California Davis Health, Sacramento, CA, ²Pathology, University of California Davis Health, Sacramento, CA
*Purpose: Delayed graft function (DGF) has been associated with adverse kidney transplant outcomes. Accurate prediction of DGF before surgery will help select organs and candidates…
2022 American Transplant Congress
Ficoll-Based Isolation Alters the Immunogenicity of Islets That Leads to Enhanced Rejection in Allogeneic Hosts
L. Zhang¹, A. Turan², M. Tarique¹, V. Ulker¹, E. Yolcu³, H. Shirwan³
¹Child Health, University of Missouri, Columbia, MO, ²Molecular Microbiology and Immunology, University of Missouri, Columbia, MO, ³Child Health and Molecular Microbiology and Immunology, University of Missouri at Columbia, Columbia, MO
*Purpose: The purification of pancreatic islets has long relied on the time-consuming density gradient separation method. We herein report a filtration method as an efficient,…
2022 American Transplant Congress
The Prediction of Renal Allograft Rejection by Time-Dependent Two-Signature Predictors
M. Liao¹, Q. Fu², L. Wei³, H. Yang³, G. Zhao³, S. Deng³, J. F. Markmann²
¹School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, ²Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ³University of Electronic Science and Technology of China, Chengdu, China
*Purpose: The study aims to develop RNA signature predictors using preemptive biopsy transcriptome data to predict future allograft rejection and reveal the predictors' time-dependent features.*Methods:…
2022 American Transplant Congress
Implications of Pre-Transplant (tx) COVID-19 on SOT or HCT: A Multicenter Study
G. Haidar¹, K. Hughes-Kramer², C. Alonso³, J. Hand⁴, E. Blodget⁵, V. Srinivasa⁵, S. Aslam⁶, H. Hassouna⁷, C. Lawson⁷, M. Malinis⁸, S. Anjan⁹, E. Lease¹⁰, M. Al-Obaidi¹¹, P. Vergidis¹², J. Husson¹³, D. van Duin¹⁴, R. Avery¹⁵, K. Downes¹⁶, M. R. Heldman¹⁰, J. Nelson¹⁷, S. Pouch¹⁸, S. Chuang¹⁹, C. Kao²⁰, M. Estabrook²¹, F. Alconchel²², S. Mazumber²³, P. Samanta², M. Wagener², N. Singh², F. Silveira²
¹UPitt, Pitt, PA, ²UPitt, Pittsburgh, PA, ³BIDMC, Boston, MA, ⁴Ochsner, New Orleans, LA, ⁵USC, Los Angeles, CA, ⁶UCSD, San Diego, CA, ⁷Spectrum Health, Grand Rapids, MI, ⁸Yale, New Haven, CT, ⁹UMiami, Miami, FL, ¹⁰UW, Seattle, WA, ¹¹U Arizona, Tucson, AZ, ¹²Mayo, Rochester, MN, ¹³UMMC, Baltimore, MD, ¹⁴UNC, Chapel Hill, NC, ¹⁵JHU, Baltimore, MD, ¹⁶CHOP, Philadelphia, PA, ¹⁷Stanford, Stanford, CA, ¹⁸Emory, Decatur, GA, ¹⁹U Rochester, Rochester, NY, ²⁰WashU, St Louis, MO, ²¹WashU, Saint Louis, MO, ²²Spain, Murcia, Spain, ²³U Tennessee, Memphis, TN
*Purpose: Describe outcomes of patients (pt) with pre-tx COVID-19.*Methods: Multicenter study of SOT/HCT candidates who had a positive (pos) SARS-CoV-2 PCR pre-tx.*Results: Pre-tx: Of 208…
2022 American Transplant Congress
Real World Experience Utilizing Donor Kidneys at Risk for Acute Kidney Injury with Belatacept Based Maintenance Immunosuppression
B. Sirandas, A. Chan, M. Eiting, T. Larson, C. Truax, L. Smith
University of Utah Health, Salt Lake City, UT
*Purpose: The demand for kidney transplant continues to rise, and limited supply has encouraged acceptance of marginal donor organs, such as those at risk for…
2022 American Transplant Congress
Evaluating the Performance and External Validity of Machine Learning-Based Prediction Models in Liver Transplantation: An International Study
T. Ivanics¹, D. So², M. P. Claasen³, D. Wallace⁴, M. Patel⁵, A. Gravely⁶, K. Walker⁷, T. Cowling⁷, L. Erdman⁸, G. Sapisochin³
¹University of Toronto - University Health Network, Toronto, ON, Canada, ²The Centre for Computational Medicine, The Hospital for Sick Children, Toronto, ON, Canada, ³Multi-organ transplant program, University Health Network, Toronto, ON, Canada, ⁴Department of Health Services Research and policy, London School of Hygiene and Tropical Medicine, London, United Kingdom, ⁵Division of Surgical Transplantation, University of Texas Southwestern Medical Center, Dallas, TX, ⁶Multi-organ transplant program, University of Toronto - University Health Network, Toronto, ON, Canada, ⁷Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom, ⁸The Centre of Computational Medicine, The Hospital for Sick Children, Toronto, ON, Canada
*Purpose: National liver transplant (LT) registries are curated in many countries. We compared data from three national registries and developed machine learning algorithm (MLA)-based models…