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American Transplant Congress abstracts

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  • 2022 American Transplant Congress

    Comprehensive Profiling of Monocytes During Cellular (TCMR) or Mixed Antibody-Mediated Rejection (ABMR) After Kidney Transplantation

    C. Macedo1, E. Bailly1, K. Louis2, X. Gu1, M. Lucas1, A. Zeevi1, P. Randhawa1, A. Bansal3, D. Metes1

    1Starzl Transplantation Institute, Pittsburgh, PA, 2INSERM UMR-S976, Paris, France, 3University of Pittsburgh, Pittsburgh, PA

    *Purpose: Monocytes play an important role in the immune defense by initiating adaptive immunity. They are heterogeneous, plastic, and present different subsets: classical (CD14++CD16-), intermediate…
  • 2022 American Transplant Congress

    Meld Score <31 Predicts Spontaneous Recovery in Patients Listed for Liver Transplantation for Alcohol-Associated Hepatitis: A UNOS Database Study

    Y. Bekki, G. Im, T. Schiano, S. Florman

    Icahn School of Medicine at Mount Sinai, RMTI, New York, NY

    *Purpose: Alcohol-associated hepatitis (AH) is the fastest growing indication for liver transplantation (LT) in the U.S. While spontaneous recovery (SR) can occur in patients with…
  • 2022 American Transplant Congress

    Controlling Instability at Reperfusion: Another Benefit of Normothermic Machine Perfusion Using OCS Liver

    C. S. Hwang1, C. Shi2, M. Patel1, J. Shah1, L. DeGregorio1, S. Hanish1, Y. Kadakia3, U. Chaudhary3, E. Okoro2, S. Cheruku2, P. Lahsaei2, P. Vagefi1, M. MacConmara4

    1Surgery, University of Texas Southwestern Medical Center, Dallas, TX, 2Anesthesia, University of Texas Southwestern Medical Center, Dallas, TX, 3University of Texas Southwestern Medical Center, Dallas, TX, 4TransMedics, Andover, MA

    *Purpose: Organ Care System (OCS) Liver is a portable ex-vivo normothermic liver perfusion device recently shown to provide superior donor organ preservation. The impact of…
  • 2022 American Transplant Congress

    Vascularized Tracheal Transplantation; A One Year Update

    E. M. Genden

    Otolaryngology- Head and Neck Surgery, The Icahn School of Medicine at Mount Sinai, New York, NY

    *Purpose: In January 2021, we performed the first single stage vascularized tracheal transplantation for reconstruction of a 9.5 cm tracheal airway defect. One year after…
  • 2022 American Transplant Congress

    Single Cell Multiomics Reveals Immune Mediators in Acute Cellular Rejection Following Pediatric Liver Transplantation

    B. Rocque1, D. Sarode2, A. Barbetta3, P. Singh4, C. Goldbeck4, C. Weaver5, O. Akbari4, R. Kohli5, J. Emamaullee6

    1University of Southern California Keck School of Medicine, Los Angeles, CA, 2Keck School of Medicine of University of Southern California, Pasadena, CA, 3Surgery, abdominal transplat, University of Southern California, Los Angeles, CA, 4Keck School of Medicine of USC, Los Angeles, CA, 5Childrens Hospital Los Angeles, Los Angeles, CA, 6University of Southern California, Los Angeles, CA

    *Purpose: Acute cellular rejection (ACR) is a common complication following pediatric liver transplantation with potential negative effects on allograft longevity. Currently, diagnosis and management are…
  • 2022 American Transplant Congress

    Absence of DAP12 Expression by Donor Liver-Derived Dendritic Cells Enhances Their Contact with T Cells in Host Secondary Lymphoid Tissue: Implications for Abrogation of MHC-mismatched Liver Transplant Tolerance in Mice

    R. Nakano, A. Perez Gutierrez, G. Camirand, D. A. Geller, A. W. Thomson

    University of Pittsburgh, Pittsburgh, PA

    *Purpose: Multiphoton intravital microscopy is a high-resolution, real-time, fluorescence imaging technique that enables study of interactions between cells in their native, 3-dimensional environment including organ…
  • 2022 American Transplant Congress

    Recoverability of Diabetic Nephropathy of Donor Kidney After Kidney Transplantation

    K. Lee, J. Park

    Samsung Medical Center, Seoul, Korea, Republic of

    *Purpose: The natural course of diabetic donors on the outcome of kidney transplantation (KT) is controversial. The aim of this study was to analyze the…
  • 2022 American Transplant Congress

    Evolution of Pretransplant Cardiac Risk Factor Burden and Major Adverse Cardiovascular Events in Liver Transplant Recipients Over Time

    C. Harrington, P. Levy, E. Cabrera, J. Gao, D. Gregory, C. Padilla, G. Crespo, L. VanWagner

    Northwestern Medicine, Chicago, IL

    *Purpose: The aim of this study is to evaluate the evolution of MACE and pre-LT cardiac risk factors in LTRs over time.*Methods: This is a…
  • 2022 American Transplant Congress

    Development and Validation of a Machine Learning Based Virtual Biopsy System in Kidney Transplant Patients

    D. Yoo1, G. Divard1, M. Raynaud1, A. Bentall2, M. Stegall3, M. Naesens4, I. Batal5, S. Coley6, J. Gill7, M. Mengel8, L. Cornell3, M. P. Alexander2, T. Coates9, C. Legendre10, P. Reese11, c. lefaucheur12, O. Aubert1, A. Loupy1

    1Paris Transplant Group, Paris, France, 2-, -, AL, 3Mayo Clinic, Rochester, MN, 4Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, 5Columbia University Medical Center, Scarsdale, NY, 6Columbia University, New York, NY, 7University of British Columbia, Vancouver, BC, Canada, 8University of Alberta, Edmonton, AB, Canada, 9University of Adelaide, Adelaide, Australia, 10Hopital Necker, Paris, France, 11University of Pennsylvania, Philadelphia, PA, 12Hôpital Saint-Louis, Paris, France

    *Purpose: In kidney TX, day-zero biopsies are used to assess organ quality and discriminate lesions inherited from the donor or acquired after transplantation. However, many…
  • 2022 American Transplant Congress

    Incidence and Outcomes of Fever of Unknown Origin After Kidney Transplant in the Modern Era

    M. Jorgenson, S. Parajuli, B. Astor, C. Saddler, J. Smith, D. Mandelbrot

    University of Wisconsin Health, Madison, WI

    *Purpose: Fever is common in kidney transplant recipients (KTRs). If an etiology is not readily apparent, a patient can be classified as having a fever…
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