Am J Transplant, Volume 22, Suppl 3 Archives - Page 88 of 190 - ATC Abstracts

2022 American Transplant Congress
Detection of CMV Mediated Sub-Clinical Rejection by Urine Biomarkers
S. Ghosh¹, R. Sarwal¹, C. Mark¹, E. Reed², J. Shoji³, S. Bunnapradist², T. Sigdel³, M. Sarwal³
¹Nephrosant Inc, San Francisco, CA, ²UCLA, Los Angeles, CA, ³UCSF, San Francisco, CA
*Purpose: Research on early detection of Cytomegalovirus (CMV) mediated sub-clinical rejection (sAR) is in its nascence. This study explores the efficacy of urine-based biomarkers for…
2022 American Transplant Congress
Detection of Alloreactive CD8+ T Cell Responses and the Immunopeptidome That Elicits Their Activation
A. B. Morris, X. Zhang, E. V. Peek, A. Hadley, C. Larsen
Emory University, Atlanta, GA
*Purpose: T cell-mediated rejection results in graft dysfunction and contributes to premature failure. Due to the complexity of the TCR:pMHC interaction, prediction of alloreactive T…
2022 American Transplant Congress
Single Nuclei RNA-Sequencing Identifies Distinct Cell Profile in Kidney Allografts with Recurrent Focal Segmental Glomerular Sclerosis (FSGS)
L. Gallon¹, E. Bardhi², J. McDaniels², A. Shetty², P. Hallack¹, C. Kuscu³, C. Kuscu³, T. Rousselle², J. Eason³, D. Maluf², V. Mas²
¹NWU, Chicago, IL, ²University of Maryland, Baltimore, MD, ³UTHSC, Memphis, TN
*Purpose: Strong evidence suggests that primary FSGS is due to a plasma factor that results in general podocyte dysfunction and risk of recurrence after kidney…
2022 American Transplant Congress
Association of Psychosocial Clearance and Race in the Kidney Transplant Evaluation Process
V. S. Valbuena¹, C. Satarino², M. S. Anderson¹, J. Obayemi¹, T. J. Iwashyna³, R. Sung¹
¹Department of Surgery, University of Michigan, Ann Arbor, MI, ²Department of Social Work, University of Michigan, Ann Arbor, MI, ³Department of Internal Medicine, University of Michigan, Ann Arbor, MI
*Purpose: The psychosocial evaluation of transplant candidates is a comprehensive assessment of the (Fig 1). Psychosocial risk factors can be the only basis for not…
2022 American Transplant Congress
Evaluation of Crushed Posaconazole Delayed Release Tablets in Lung Transplant Recipients
R. Gordon¹, K. Dewey¹, R. Jariwala¹, B. Yen¹, J. Kukreja², S. Hays², J. Singer², R. Florez¹
¹Department of Clinical Pharmacy, University of California, San Francisco, San Francisco, CA, ²University of California, San Francisco, San Francisco, CA
*Purpose: We hypothesized that crushed posaconazole delayed release (POSA DR) tablets can reach therapeutic levels in lung transplant recipients who are at risk for invasive…
2022 American Transplant Congress
A Multi-Center Study Assessing the Association of Frailty with Infection in Kidney Transplant Recipients
M. Malinis¹, M. Abidi², E. Benamu², N. Jakharia³, N. Law⁴, R. Sigler⁴, R. Nog⁵, S. Olivier⁵, S. Taimur⁶, N. Theodoropoulos⁷, J. Schaenman⁸
¹Yale University School of Medicine, New Haven, CT, ²University of CO, Aurora, CO, ³Stanford, Palo Alto, CA, ⁴UCSD, San Diego, CA, ⁵Westchester Med Ctr, Westchester, NY, ⁶Mount Sinai SOM, New York, NY, ⁷Univ of MA, Worcester, MA, ⁸UCLA, Los Angeles, CA
*Purpose: Frailty is a multi-dimensional characterization of decreased reserve and diminished response to stressors in older adults. Frailty at the time of transplant has been…
2022 American Transplant Congress
HLA-Specific IgD/CD27 Double Negative B Cell Frequency Assessed by a Novel Multiplex Bead-Based Assay Predicts Rejection in Kidney Transplant Recipients
Z. Ilyas¹, A. Akl², D. Pinelli¹, L. Gallon³, A. Tambur¹, M. Ansari⁴
¹Northwestern University, Chicago, IL, ²Dr. Soliman Fakeeh Hospital, Jeddah, Saudi Arabia, ³Northwestern Univ NMFF, Chicago, IL, ⁴Medicine, Northwestern University, Chicago, IL
*Purpose: Recipients with sensitization to HLA defined by a high percentage of Panel Reactive Antibodies (PRA) or Donor-specific anti-HLA antibodies (DSA) are at higher immunologic…
2022 American Transplant Congress
Synergistic Effect of CXCR5⁺CD8⁺ T_Ab-supp Cell Adoptive Cell Therapy and mTOR Inhibition (but Not Calcineurin Inhibition) in Suppressing Alloantibody Following Kidney Transplant in Mice
J. L. Han¹, J. M. Zimmerer¹, Q. Zeng², S. Chaudhari¹, C. K. Breuer², G. L. Bumgardner¹
¹Dept. of Surgery, The Ohio State University, Columbus, OH, ²Center for Regen. Med., The Research Institute at Nationwide Children's Hospital, Columbus, OH
*Purpose: We have reported that CXCR5+CD8+TAb-supp cells mediate suppression of alloantibody (alloAb) production and prolong graft survival in both hepatocellular and kidney transplant (KTx) mouse…
2022 American Transplant Congress
Compliance with OPTN Infectious Disease Testing
L. Irwin
Massachusetts General Hospital, Boston, MA
*Purpose: Effective 3/1/21 OPTN policy requires all transplant recipients to have pre-transplant and post-transplant infectious disease testing performed at specific intervals: upon admission and prior…
2022 American Transplant Congress
Treading the Paradigm Shift: A Single Center Comparative Study of Outcomes Between Pre-Emptive and Early Kidney Transplant with Non Pre-Emptive Kidney Transplant Recipients Innational Kidney and Transplant Institute
E. U. Go, L. Baloloy
Organ Transplantation and Vascular Surgery, National Kidney and Transplant Institute, Quezon City, Philippines
*Purpose: To compare the 3-year outcome of pre-emptive and early kidney transplant recipients versus non pre-emptive recipients in our institution from January 2013 to December…