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American Transplant Congress abstracts

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  • 2022 American Transplant Congress

    Generation and Functional Characterization of Bio-Engineered Livers for Heterotopic Implantation in Porcine Model of Acute Liver Failure

    A. A. Katane1, B. P. Amiot2, A. R. Stumbras1, A. Mendenhall1, N. R. Palumbo1, A. C. Donepudi1, J. J. Ross1, S. L. Nyberg3

    1Miromatrix Medical Inc, Eden Prairie, MN, 2Department of Surgery, Mayo Clinic, Rochester, MN, 3William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN

    *Purpose: Liver transplantation has shown to be an effective therapy for the end-stage liver diseases (ESLD). However, as donor organ shortages increase, organ engineering technology…
  • 2022 American Transplant Congress

    Bionic Pancreas – 3D Bioprinting of a Bionic Organ with a Vascular System – Results of Transplantation in Large Animals

    M. Wszola1, M. Klak2, A. Berman3, M. Kolodziejska1, T. Bryniarski1, G. Tymicki1, T. Dobrzanski1, D. Szkopek4, K. Roszkowicz-Ostrowska5, J. Wolinski5, A. Dobrzyn6, A. Kaminski7

    1Foundation of Research and Science Development, Warsaw, Poland, 2Foundation for Research and Science Development, Warsaw, Poland, 3Polbionica Ltd., Warsaw, Poland, 4Institute of Animal Physiology and Nutrition Jan Kielanowski of the Polish Academy of Sciences,, Jabłonna, Poland, 5Institute of Animal Physiology and Nutrition Jan Kielanowski of the Polish Academy of Sciences, Jablonna, Poland, 6Laboratory of Cell Signaling and Metabolic Disorders, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Warsaw, Poland, 7Department of Transplantology and Central Tissue Bank, Medical University of Warsaw, Warsaw, Poland

    *Purpose: There is lack organs for transplantation. The transplantation of the pancreas is recommended in diabetes with complications. The combination of cell biology and 3D-bioprinting…
  • 2022 American Transplant Congress

    QSant, a Novel Urine Test Monitors Recovery of Allograft Injury After DGF

    S. Ghosh1, H. Tedesco2, R. Sarwal1, N. Titzler1, W. Yazar1, M. Nakamura2, J. Pestana2, M. Sarwal1

    1Nephrosant, Brisbane, CA, 2Hospital do Rim, Sao Paolo, Brazil

    *Purpose: We evaluate urine QSant assay to non-invasively monitor recovery of allograft injury, post delayed graft function(DGF).*Methods: 65 HLA-DR matched, renal allograft recipients, on TAC/MMF/prednisone…
  • 2022 American Transplant Congress

    A Third Dose of SARS-CoV-2 Vaccine Increases Neutralizing Antibodies Against Variants of Concern in Solid Organ Transplant Recipients

    A. H. Karaba1, X. Zhu1, T. Ling1, K. H. Wang1, A. G. Rittenhouse1, O. Akinde1, Y. Eby1, J. E. Ruff1, J. N. Blankson1, A. T. Abedon1, J. L. Alejo1, A. L. Cox1, J. R. Bailey1, E. A. Thompson1, S. L. Klein1, D. S. Warren1, J. M. Garonzik-Wang2, B. J. Boyarsky1, I. Sitaras1, A. Pekosz1, D. L. Segev1, A. A. Tobian1, W. A. Werbel1

    1Johns Hopkins University, Baltimore, MD, 2University of Wisconsin School of Medicine and Health, Madison, WI

    *Purpose: Vaccine-induced SARS-CoV-2 antibody responses are attenuated in solid organ transplant recipients (SOTRs) and breakthrough infections are more common. Additional SARS-CoV-2 vaccine doses increase anti-spike…
  • 2022 American Transplant Congress

    Concurrent Use of Two Methods Prevents Erroneous HLA Typing of Deceased Organ Donors – An Essential Strategy for Patient Safety and Accurate Virtual Crossmatching for Broader Sharing

    R. Rajalingam, T. dela Cruz, C. Dames, L. Pagaduan, Y. Cho, D. Kong

    Immunogenetics and Transplantation Laboratory (ITL), University of California San Francisco, San Francisco, CA

    *Purpose: Comprehensive and accurate typing for ever-increasing alleles of all eleven HLA genes within a short turnaround time is a crucial initial step for allocating…
  • 2022 American Transplant Congress

    The Impact of New-Onset Diabetes After Transplantation on Survival and Major Cardiovascular Events in Korean Kidney Transplantation Recipients

    E. Kang1, J. Lee2, D. Kang3, Y. Jang4, S. Park5, Y. Kim4, D. Kim4, K. Joo4, Y. Kim4, M. Park6, Y. Lim7, H. Lee4

    1Ewha Womans University Seoul Hospital, Seoul, Korea, Republic of, 2Dongguk University Ilsan Hospital, Goyang, Korea, Republic of, 3Chung-Ang University, Seoul, Korea, Republic of, 4Seoul National University Hospital, Seoul, Korea, Republic of, 5Seoul National University College of Medicine, Seoul, Korea, Republic of, 6Informations and Statistics, Chungnam National University, Daejeon, Korea, Republic of, 7Applied Statistics, Chung-Ang University, Seoul, Korea, Republic of

    *Purpose: New-onset diabetes after transplantation (NODAT) is a frequent complication in kidney transplant (KT) recipients with unfavorable outcomes, although a nationwide study on epidemiology and…
  • 2022 American Transplant Congress

    Team Decision-Making in Liver Transplant Evaluation: A Multi-Center Ethnographic Observation Study

    C. N. Sidoti, H. C. Sung, D. L. Segev, M. L. Levan, T. S. Purnell, A. T. Strauss

    Johns Hopkins School of Medicine, Baltimore, MD

    *Purpose: Transplant providers are tasked with making ethically complex and high-stakes decisions of determining a patient’s candidacy for liver transplantation within a multi-disciplinary team. We…
  • 2022 American Transplant Congress

    Deletion of AIF-1 Promotes Kidney Reparative Macrophages and Prevents Fibrosis

    I. Husain, A. Dangi, X. Luo

    Duke University School of Medicine, Durham, NC

    *Purpose: A major etiology contributing to poor allograft survival is the inevitable ischemic insult it incurs during transplantation. Macrophages are key players in ischemia-reperfusion injury,…
  • 2022 American Transplant Congress

    Urine-based Assay For Detection Of Acute Rejection In Pediatric Kidney Transplant Recipients

    C. Crane1, K. Zeeb2, E. Phebus2, C. Benavides2, W. Wong3, E. Ingulli2

    1UCSD/Rady Children's Hospital, San Diego, CA, 2UCSD Rady Children's Hospital, San Diego, CA, 3Massachusetts General Brigham, Boston, MA

    *Purpose: Biomarkers such as donor-derived cell free DNA (cfDNA) and gene expression profiling are utilized in adult transplant patients (pts), but these tests lack sensitivity…
  • 2022 American Transplant Congress

    Graft and Patient Outcomes of Kidney Transplant Tourism: A Single-Center Experience

    A. Altheaby1, R. Algain2, R. Salem2, A. Alotaibi2, K. Owaidah2, M. Tawahri1, M. Shaheen3, Z. Arabi4

    1Nephrology, King Abdulaziz Medical City-NGHA, Riyadh, Saudi Arabia, 2Internal Medicine, King Abdulaziz Medical City-NGHA, Riyadh, Saudi Arabia, 3King Saud Bin Abdulaziz for Health Sciences, Riyadh, Saudi Arabia, 4Renal Transplant, King Abdulaziz Medical City-NGHA, Riyadh, Saudi Arabia

    *Purpose: The expanding supply-demand mismatch between organs available for transplantation and patients in need led to the growth of transplant tourism. In our study, we…
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