ATC Abstracts

American Transplant Congress abstracts

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  • 2022 American Transplant Congress

    Pretransplant Recipient TNFR2+T Regulatory Cell Frequency Predicts Long-Term Outcomes After Kidney Transplantation

    A. Kouyoumdjian, N. Saberi, S. Negi, J. Tchervenkov, S. Paraskevas

    McGill University Health Centre, Montreal, QC, Canada

    *Purpose: Pre-transplant indices capable of predicting long-term renal allograft function could improve graft allocation strategies. We previously associated pretransplant frequency of Tumor Necrosis Factor Receptor…
  • 2022 American Transplant Congress

    P2X7R Signaling Controls Exosome Release by Macrophages and Donor MHC Cross-Dressing After Skin Transplantation

    H. H. Lancia1, N. Carnel2, A. G. Lellouch1, C. Cetrulo1, G. Benichou2

    1Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 2Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA

    *Purpose: Exosomes released by transplanted organs play an important role in the host's immune response leading to their rejection. Donor exosomes contribute to alloimmunity by…
  • 2022 American Transplant Congress

    Proteome Profiling of Recurrent Primary Focal Segmental Glomerulosclerosis (FSGS) Plasma Samples Reveals Potential Proteins Involved in Primary FSGS

    L. Gallon1, N. Ahsan2, V. Mas3, J. Leventhal1, L. Fornelli2

    1Northwestern Univ NMFF, Chicago, IL, 2Mass Spectrometry, Proteomics and Metabolomics Core Facility, Department of Chemistry and Biochemistry, The University of Oklahoma, Oklahoma, OK, 3University of Maryland, Baltimore, MD

    *Purpose: The presumed etiology of primary FSGS is a plasma factor that results in general podocyte dysfunction with partial and/or unpredictable response to immunosuppressive therapy…
  • 2022 American Transplant Congress

    Social Determinants of Health Are Associated with Pre-Emptive Wait Listing and Do Not Fully Account for Racial Gap in Early Access to the Waitlist

    A. M. Zehner1, L. A. Cartwright2, T. Mupfudze2, T. Wilson2, A. Placona2, B. Carrico2

    1Research Department, United Network for Organ Sharing, Richmond, VA, 2Research Department, UNOS, Richmond, VA

    *Purpose: We leveraged a novel data linkage of candidate-level indicators of social determinants of health (SDOH) among kidney waitlist candidates in the United States to…
  • 2022 American Transplant Congress

    Predicted Performance of Bayesian-Based Precision Dosing Software for Tacrolimus

    A. Seghezzo1, J. Kerr1, A. Gupta2, A. Ta2, L. Powell2, A. Feist3

    1University of California San Diego Health, San Diego, CA, 2PrecisePK, San Diego, CA, 3UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences, San Diego, CA

    *Purpose: Bayesian-based precision dosing software (BPDS) has been utilized for therapeutic drug monitoring to optimize medication use. However, BPDS for tacrolimus (TAC) is not routinely…
  • 2022 American Transplant Congress

    T and B Cell Response to 3 Dose Covid Vaccine Series for Kidney Transplant Patients on Belatacept

    J. Christensen1, I. Yakubu2, D. Kumar1, D. Cornett3, M. A. Miller3, M. Altrich3, L. Flebbe-Rehwaldt3, R. Thompson1, G. Gupta1

    1Internal Medicine, Transplant Nephrology, VCUHealth, Richmond, VA, 2Pharmacy, VCUHealth, Richmond, VA, 3Eurofins Viracor, Lee's Summit, MO

    *Purpose: Data shows COVID vaccine response after 2 doses in patients on Belatacept immunosuppression (IS) is low, with reported rates of seroconversion (as measured by…
  • 2022 American Transplant Congress

    Development and Validation of an Integrative DD-CFDNA System to Predict Allograft Rejection: A Population Based Study

    O. Aubert, R. Brousse, J. Gueguen, M. Racape, C. Lefaucheur, A. Loupy

    Paris Translational Center for Organ Transplantation, Paris, France

    *Purpose: Post-transplantation patient care requires development and validation of non-invasive biomarkers to improve allograft monitoring and prevention from unnecessary and costly biopsies. Reports have suggested…
  • 2022 American Transplant Congress

    Rejection After Liver Transplantation: What Can We Learn from Transcriptomic Analysis?

    H. J. Braun1, D. Amara2, A. Zarinsefat1, G. Szabo1, Z. Laszik1, P. Stock1, N. Ascher1

    1University of California, San Francisco, San Francisco, CA, 2UCLA, Los Angeles, CA

    *Purpose: Acute cellular rejection (ACR) can occur at any time following liver transplantation (LT); initial ACR within 6 months is most common and occurs in…
  • 2022 American Transplant Congress

    Status 7: Parking Lot or Loading Zone?

    E. Wells, M. Robinson, S. Blais, A. Chacon, S. Greve, R. Villicana, C. Bratton, K. Talavera, M. de Vera, S. Regmi, T. Hoang, J. Woloszyn, R. Rattanavich

    Transplant Institute, Loma Linda University Health, Loma Linda, CA

    *Purpose: Kidney waitlist management continues to be a challenge for many transplant centers for a variety of reasons. Over the years, the number of Status…
  • 2022 American Transplant Congress

    Treading the Paradigm Shift: A Single Center Comparative Study of Outcomes Between Pre-Emptive and Early Kidney Transplant with Non Pre-Emptive Kidney Transplant Recipients Innational Kidney and Transplant Institute

    E. U. Go, L. Baloloy

    Organ Transplantation and Vascular Surgery, National Kidney and Transplant Institute, Quezon City, Philippines

    *Purpose: To compare the 3-year outcome of pre-emptive and early kidney transplant recipients versus non pre-emptive recipients in our institution from January 2013 to December…
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