Am J Transplant, Volume 22, Suppl 3 Archives - Page 81 of 190 - ATC Abstracts

2022 American Transplant Congress
Recipient and Grafts Outcomes in Simultaneous Kidney and Pancreas Transplantation with Steroid Avoidance in the United States
A. Cerise¹, A. Dinesh², V. Humphreville², S. Jackson³, R. Kandaswamy², S. Riad⁴
¹Surgery, University of Minnesota, Minnesota, MN, ²Surgery, University of Minnesota, Minneapolis, MN, ³Analytics, MHealth-Fairview, Minneapolis, MN, ⁴Medicine, University of Minnesota, Eden Prairie, MN
*Purpose: Steroid avoidance in kidney transplantation has been proven non-inferior. Data on steroid avoidance in simultaneous pancreas-kidney (SPK) is scant.*Methods: We utilized the Scientific Registry…
2022 American Transplant Congress
Differences in Medication Adherence Between Preemptive and Post-Dialysis Young Kidney Transplant Recipients
Y. Vaisbourd¹, E. Samson², A. De Simone², M. Dahhou², B. Foster³
¹Pediatrics, McGill University, Montréal, QC, Canada, ²McGill University, Montréal, QC, Canada, ³Montreal Children's Hospital, Montreal, QC, Canada
*Purpose: The mechanisms underlying the superior graft survival associated with pre-emptive kidney transplantation, compared with transplantation following a period of dialysis, are unknown. Selection for…
2022 American Transplant Congress
Kidney Grafts with Poor 24-Month Function Present Upregulated Immune Activity at Pre-Transplantation
E. Bardhi¹, K. Archer², D. Maluf¹, J. McDaniels¹, T. Rousselle¹, E. Akalin³, T. Mueller⁴, V. Mas¹
¹University of Maryland, Baltimore, MD, ²Ohio State University, Columbus, OH, ³Montefiore Medical Center, Bronx, NY, ⁴University Hospital Zürich, Zürich, Switzerland
*Purpose: A transcriptomic profile serves as a snapshot of the temporary cell state and thus, analyzing pretransplant kidney biopsies can provide detailed information on the…
2022 American Transplant Congress
Early Mortality After Liver Transplant is Associated with Pre-Transplant Alterations in Monocyte Phenotype and Gene Expression
L. Jin¹, A. Lemenze², G. Panayotova¹, S. Simonishvili¹, Y. Qin¹, T. Ayorinde¹, G. Prakash¹, L. J. Minze³, F. Paterno¹, L. Brown¹, A. Amin¹, X. C. Li³, R. Ghobrial³, J. V. Guarrera¹, K. E. Lunsford¹
¹Department of Surgery, Rutgers New Jersey Medical School, Newark, NJ, ²Center for Immunity and Inflammation, Rutgers Biomedical and Health Sciences, Newark, NJ, ³J.C. Walter Jr. Center for Transplantation, Houston Methodist Hospital, Houston, TX
*Purpose: Persistence of pre-liver transplant (LT) immune dysfunction (immune frailty) significantly increases post-LT morbidity and mortality. We have identified a pre-LT biomarker panel, the liver…
2022 American Transplant Congress
A Decennial Summary of the OPTN Kidney Paired Donation Pilot Program
K. Gauntt¹, A. Toll¹, J. Musick¹, P. Kennealey², J. Kim³, T. Sandholm⁴, R. Leishman¹
¹United Network For Organ Sharing, Richmond, VA, ²University of Colorado Hospital, Aurora, CO, ³Keck Medicine of USC, Los Angeles, CA, ⁴Carnegie Mellon University, Pittsburgh, PA
*Purpose: The OPTN Kidney Paired Donation Pilot Program (KPDPP) is a national KPD system that has served the kidney transplant community for over 10 years.…
2022 American Transplant Congress
HLA-DQ Mismatches Are More Likely to Be Listed as Unacceptable Antigens After Renal Graft Failure in African American Recipients as Compared to Other Racial/Ethnic Groups
D. Isaacson¹, M. W. Gmeiner², V. Kosmoliaptsis³, J. D. Schold⁴, A. R. Tambur¹
¹Northwestern University, Chicago, IL, ²London School of Economics, London, United Kingdom, ³Cambridge University, Cambridge, United Kingdom, ⁴Cleveland Clinic, Cleveland, OH
*Purpose: Growing evidence suggests that donor-recipient mismatches at the HLA-DQ locus are the most immunogenic and pathogenic, evidenced by generation of DQ donor-specific antibodies (DSA).…
2022 American Transplant Congress
Tacrolimus Exposure Estimation in Stable Kidney Transplant Recipients Using Maximum A Posteriori Bayesian Approach
T. Nguyen¹, N. M. Smith¹, K. Attwood², B. Murray³, K. Tornatore-Morse¹
¹University at Buffalo School of Pharmacy and Pharmaceutical Sciences, Buffalo, NY, ²School of Public Health; University at Buffalo, Buffalo, NY, ³Erie County Medical Center; School of Medicine/UB, Buffalo, NY
*Purpose: Tacrolimus exhibits interpatient pharmacokinetic variability that impacts clinical responses and requires routine trough therapeutic drug monitoring. Tacrolimus troughs do not consistently predict area under…
2022 American Transplant Congress
Augmented Reality in Hand-Assisted Retroperitoneal Donor Nephrectomy – Procedure Step Adjusted Evaluation for the Surgeons’ Benefits
R. Wahba¹, L. Krames², J. Hogervorst³, R. R. Datta¹, M. N. Thomas¹, P. Suppa³, D. L. Stippel¹
¹Department of General, Visceral, Cancer and Transplantation Surgery, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Köln, Germany, ²Karlsruhe Institute of Technology, Institute of Biomedical Engineering (IBT), Karlsruhe, Germany, ³Olympus Surgical Technologies Europe, Hamburg, Germany
*Purpose: To identify procedure steps where a patient-specific CT-reconstructed virtual 3D model of the kidney displayed on the screen can support the surgeon while performing…
2022 American Transplant Congress
Variable Course of Hepatitis A Virus Infection in Solid Organ Transplant Recipients
A. Vostal¹, J. Husson², A. Shishido¹, N. Jakhete³, E. Moore⁴, X. Wen⁵, A. Amoroso², R. Meier⁶, E. Wilson², K. K. Saharia²
¹Div. of Infectious Diseases, Univ. of Maryland Medical Center, Baltimore, MD, ²Div. of Infectious Diseases, Univ. of Maryland School of Medicine and Institute of Human Virology, Baltimore, MD, ³Div. of Hepatology, Univ. of Maryland School of Medicine, Baltimore, MD, ⁴Dept of Surgery, Brooklyn Hospital Center, Brooklyn, NY, ⁵Dept. of Surgery, Univ. of Florida, Gainesville, FL, ⁶Dept. of Surgery, Univ. of Maryland School of Medicine, Baltimore, MD
*Purpose: Although Hepatitis A virus (HAV) infection is typically a self-limited disease in immunocompetent individuals, the natural history and viral kinetics of HAV in solid…
2022 American Transplant Congress
One Nuclei at a Time: Decoding Kidney Allograft Fibrosis by Single Nuclei RNA-Sequencing
J. McDaniels¹, A. Shetty¹, C. Kuscu², C. Kuscu², E. Bhardi¹, T. Rousselle¹, C. Drachenberg³, M. Talwar⁴, J. Eason⁵, T. Muthukumar⁶, D. Maluf¹, V. Mas¹
¹University of Maryland, Baltimore, Baltimore, MD, ²University of Tennessee Health Science Center, Memphis, TN, ³University of Maryland, Baltimore, MD, ⁴UTHSC, memphis, TN, ⁵University of Tennessee/Methodist Transplant Institute, Memphis, TN, ⁶Weill Cornell Medicine, New York, NY
*Purpose: The biological mechanisms underpinning late graft loss due to chronic allograft dysfunction remain unknown. Single nuclei RNA-sequencing (snRNAseq) of healthy and fibrotic kidney grafts…