Am J Transplant, Volume 22, Suppl 3 Archives - Page 79 of 190 - ATC Abstracts

2022 American Transplant Congress
Complement 5 Regulation Ameliorates Antibody-Mediated Rejection After Liver Transplantation in Rats
T. Tajima¹, K. Hata¹, J. Kusakabe¹, H. Miyauchi¹, X. Zhao¹, S. Kageyama¹, T. Okamoto¹, Y. Wang², E. Hatano¹
¹Dept. of HBP Surgery & Transplantation, Kyoto University, Kyoto, Japan, ²Alexion Pharmaceuticals Inc., New Haven, CT
*Purpose: Antibody-mediated rejection (AMR) is a refractory rejection after donor-specific antibody (DSA)-positive or blood-type incompatible organ transplantation. Since AMR significantly deteriorates transplant outcomes, there is…
2022 American Transplant Congress
Impact of COVID-19 on Increased Mortality in Liver Transplant Recipients in United States
K. Okumura, A. Dhand, R. Misawa, H. Sogawa, R. Bodin, D. C. Wolf, S. Nishida
Westchester Medical Center / New York Medical College, Valhalla, NY
*Purpose: COVID-19 pandemic has had a significant impact on access to routine healthcare in both hospitalized and out-patient settings. This impact was also noted in…
2022 American Transplant Congress
Gene Profiling to Distinguish Mechanisms of Liver Allograft Rejection and Acceptance in Cynomolgus Monkey
H. Sakai¹, E. Berglund¹, S. Chaudhry¹, Y. Kato¹, E. Duggan¹, J. Weiner¹, P. Alonso-Guallart¹, N. Llore¹, K. Brustle¹, J. Stern¹, B. Piegari¹, D. Ekanayake-Alper¹, M. Martinez², G. Pierre¹, M. Danton¹, S. Kofman¹, D. Ordanes¹, D. Hajosi¹, J. Lefkowitch³, A. Iuga¹, T. Kato⁴, A. Griesemer¹
¹Columbia Center for Translational Immunology, Columbia University, New York, NY, ²Department of Pediatrics, Columbia University, New York, NY, ³Departments of Pathology and Cell Biology, Columbia University, New York, NY, ⁴Department of Surgery, Columbia University, New York, NY
*Purpose: Liver is an immune regulatory organ. Spontaneous resolutions from rejection have been seen in our orthotopic cynomolgus monkey liver transplant models for tolerance induction…
2022 American Transplant Congress
Laparoscopic Kidney Transplantation : A Lost Art ?
F. J. Osella¹, I. Cabrera¹, J. Walther², L. Leon², O. Guardia², M. Rial²
¹Surgery - Kidney and Pancreas Trasplant, ITAC by Diaverum, Buenos Aires, Argentina, ²Nephrology, ITAC by Diaverum, Buenos Aires, Argentina
*Purpose: Laparoscopic surgery and currently robot-assisted surgery have transformed the current surgery paradigm, showing a lower systemic inflammatory response, less post-operative pain, smaller incisions, shorter…
2022 American Transplant Congress
Factors Predicting Early Extubation After Liver Transplantation
V. Subramanian¹, O. Bishr², J. Buggs¹, N. Kemmer¹, K. Dhanireddy¹
¹Transplant Institute, Tampa General Hospital, Tampa, FL, ²University of South Florida, Tampa, FL
*Purpose: Early extubation (either intraoperative or within 6 hours post operatively) is an important component of enhanced recovery pathways. The goal of the study was…
2022 American Transplant Congress
Risk Factors Associated with Medium-Term Allograft and Recipient Survival: Learned from 1,587 Adults with Single Kidney Transplantation
S. Chang¹, B. Liu¹, D. Du¹, N. Gong², L. Zhu¹, G. Chen¹, W. Zhang¹, Z. Chen²
¹Institute of Organ Transplantation,Tongji Hospital,Tongji Medical College,HUST, Wuhan, China, ²Huazhong University of Science and Technology, Wuhan, China
*Purpose: Retrospectively investigated the reason for graft failure during the perioperative period and discussed whether DGF and the high SCr level in a short time…
2022 American Transplant Congress
Comparison of Perioperative Antibiotic Prophylaxis Regimens on Surgical Site Infections in Pancreas Transplant Recipients
Z. A. Yetmar¹, M. McCord², B. Lahr³, A. Lemke², P. G. Dean⁴, Y. C. Kudva⁵, M. T. Seville⁶, W. Bosch⁷, S. A. Bernard², E. Beam¹
¹Division of Infectious Diseases, Mayo Clinic, Rochester, MN, ²Department of Pharmacy, Mayo Clinic, Rochester, MN, ³Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, ⁴Division of Transplantation Surgery, Mayo Clinic, Rochester, MN, ⁵Division of Endocrinology, Diabetes, Metabolism & Nutrition, Mayo Clinic, Rochester, MN, ⁶Division of Infectious Diseases, Mayo Clinic, Scottsdale, AZ, ⁷Division of Infectious Diseases, Mayo Clinic, Jacksonville, FL
*Purpose: Pancreas transplant recipients are at high risk of surgical site infection (SSI), with rates ranging from 9-45%. Several risk factors for SSI have been…
2022 American Transplant Congress
Perturbations in Podocyte Transcriptome and Biological Pathways Induced by Injury Caused by FSGS Associated Circulating Factors
P. Rashmi¹, T. Sigdel¹, D. Rychkov¹, I. Damm¹, F. Vincenti¹, C. Craik¹, J. Reiser², M. Sarwal¹
¹UCSF, San Francisco, CA, ²Rush University, Chicago, IL
*Purpose: Focal segmental glomerulosclerosis (FSGS) remains a disease without specific therapy for primary disease and a high rate of recurrence after renal transplant. Circulating factors…
2022 American Transplant Congress
Deficiency of Antibody-Suppressor CXCR5⁺CD8⁺ TCells (Not CD4⁺ T_regs) Drive High Alloantibody Production in CCR5 KO Kidney Transplant Recipients
J. L. Han¹, J. M. Zimmerer¹, Q. Zeng², S. Chaudhari¹, C. K. Breuer², G. L. Bumgardner¹
¹Dept of Surgery, The Ohio State University, Columbus, OH, ²Center for Regen. Med., The Research Institute at Nationwide Children's Hospital, Columbus, OH
*Purpose: Kidney transplant (KTx) into CCR5 KO mice is an excellent model to study AMR immunobiology due to high alloantibody (alloAb) production, rapid allograft rejection,…
2022 American Transplant Congress
Understanding the Heterogeneity of Alloreactive Natural Killer (NK) Cell Function in Kidney Transplant Recipients
D. Ruan, M. Fribourg, N. Chun, P. Cravedi, A. Horowitz, P. Heeger
Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Emerging evidence indicates that human NK cells are a heterogeneous population of lymphocytes that are activated upon ligation of one or more activating receptors…