Am J Transplant, Volume 22, Suppl 3 Archives - Page 78 of 190 - ATC Abstracts

2022 American Transplant Congress
Impact of Donor and Recipient Characteristics on Early Post-Transplant Donor-Derived Cell-Free DNA (dd-cfDNA) Scores
A. Alam¹, J. Zeng², J. Teuteberg³, S. Hall¹
¹Baylor University Medical Center, Dallas, TX, ²CareDx, Brisbane, CA, ³Stanford University, Stanford, CA
*Purpose: Dd-cfDNA (AlloSure, CareDx; Brisbane, CA) has been demonstrated to detect allograft injury after heart transplantation in a large and diverse patient cohort in the…
2022 American Transplant Congress
The Molecular Landscape of Bk Polyomavirus Infection in Kidney Transplant Recipients at Single Cell Resolution
P. J. McCown, E. Farkash, F. Alakwaa, F. Eichinger, R. Menon, E. Otto, C. C. Berthier, K. J. Woodside, S. Norman, M. Kretzler, A. Naik
University of Michigan, Ann Arbor, MI
*Purpose: BK polyomavirus has devastating consequences in patients with kidney transplants. While in vitro studies in primary epithelial cell lines, and bulk transcriptomic studies in…
2022 American Transplant Congress
Comparative Analysis of Liver Organ Offers Pre- and Post- Acuity Circle Policy Change in the US
V. Reddy¹, R. Ruiz², H. Fernandez³, J. Bayer³, E. Martinez³, A. Gupta³, G. McKenna⁴, N. Onaca³, S. Lee³, T. Ma³, G. Testa³, A. Wall³
¹Baylor Scott and White Research Institute, Allen, TX, ²Baylor University Medical Center, Fort Worth, TX, ³Baylor University Medical Center, Dallas, TX, ⁴Baylor Simmons Transplant Inst, Dallas, TX
*Purpose: With the intended goal of reducing geographic inequities, the United Network for Organ Sharing (UNOS) and Organ Procurement and Transplantation Network (OPTN) transitioned to…
2022 American Transplant Congress
The Roles of Intrarenal B Cells in Regulating Antibody Mediated Rejection After Kidney Transplantation
H. Zhang¹, C. Cavazzoni¹, E. Bechu¹, B. Hanson¹, M. A. Podestà¹, D. Kreisel², A. Alessandrini³, P. Sage¹
¹Transplantation Research Center, Renal Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ²Department of Surgery, Washington University in St Louis, St. Louis, MO, ³Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard, Boston, MA
*Purpose: Alloimmune rejection after kidney transplantation is associated with substantial infiltration of immune cells such as T and B cells in transplanted grafts. However, the…
2022 American Transplant Congress
Pre-Transplant Ex-Vivo Analysis of Kidney Vasculature and Perfusion Using Contrast Computed Tomography
A. Feizi¹, J. R. DiRito¹, M. Harris¹, J. C. Stendahl¹, S. Spindler¹, C. M. Edwards¹, T. Lysyy¹, S. Lee¹, N. Boutagy¹, A. Fehér¹, P. Yoo¹, S. A. Hosgood², D. C. Mulligan¹, M. L. Nicholson², A. J. Sinusas¹, D. J. Haakinson¹, G. T. Tietjen¹
¹Yale School of Medicine, New Haven, CT, ²University of Cambridge, Cambridge, United Kingdom
*Purpose: Ex-vivo normothermic perfusion (NMP) has been developed with the goal of improving viability of the thousands of donated organs that are declined for transplant…
2022 American Transplant Congress
Racial Disparities in Preemptive Kidney Transplantation Beyond Listing Estimated Glomerular Filtration Rate
K. L. King¹, S. Husain², S. Mohan²
¹Medicine - Nephrology, Columbia University Medical Center, New York, NY, ²Columbia University Medical Center, New York, NY
*Purpose: Given recent attention on the impact of the race coefficient in equations for estimated glomerular filtration rate (eGFR) on racial disparities in kidney transplantation,…
2022 American Transplant Congress
Development of a Radiomics-Based Model to Predict Graft Fibrosis in Liver Transplant Recipients: A Pilot Study
F. Qazi Arisar¹, E. Salinas-Miranda², H. Ale Ali², K. Lajkosz³, C. Chen¹, A. Azhie¹, G. M. Healy², D. Deniffel², M. A. Haider², M. Bhat¹
¹Ajmera Transplant Program, University Health Network, Toronto, ON, Canada, ²Lunenfeld Tanenbaum Research Institute, Toronto, ON, Canada, ³Department of Biostatistics, University Health Network, Toronto, ON, Canada
*Purpose: Recurrent fibrosis complicates 40% of Liver transplants (LT), compromising long-term survival. We evaluated the ability of a model combining radiomic features on CT scans…
2022 American Transplant Congress
De Novo Donor-Specific Antibody Development with Mycophenolate versus Azathioprine in Lung Transplant Recipients
A. Prom¹, K. Walter², K. Gomez³, C. Doligalski¹, L. Lobo¹, R. Evans¹
¹UNC Health, Chapel Hill, NC, ²University of Michigan, Ann Arbor, MI, ³University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC
*Purpose: The effect of mycophenolate mofetil (MMF) or azathioprine (AZA) immunosuppression (ISN) regimens on de novo donor specific antibody (DSA) formation in lung transplant recipients…
2022 American Transplant Congress
Lack of Measles Immunity and Vaccination Rates in Patients Being Evaluated for Solid Organ Transplant: Missed Opportunities
C. Larsen¹, C. Kotton²
¹Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, ²Massachusetts General Hospital, Boston, MA
*Purpose: Solid organ transplant (SOT) recipients are not eligible for live-vaccines, including the measles, mumps and rubella (MMR) vaccine, due to safety concerns on immunosuppression.…
2022 American Transplant Congress
Temporal Changes in the Peripheral Immune Profile of Acute Rejection Highlight New Mechanisms of Alloimmunity and Potential Non-Invasive Biomarkers of Rejection in Pediatric Liver Transplantation
D. N. Sarode¹, B. Rocque¹, A. Barbetta¹, P. Singh¹, C. Goldbeck¹, C. Weaver², O. Akbari¹, R. Kohli², J. Emamaullee¹
¹University of Southern California Keck School of Medicine, Los Angeles, CA, ²Children's Hospital Los Angeles, Los Angeles, CA
*Purpose: Acute rejection (AR) is common in pediatric liver transplantation (LT) and can impact late graft loss. Immune subpopulations mediating AR in LT have not…