Am J Transplant, Volume 22, Suppl 3 Archives - Page 76 of 190 - ATC Abstracts

2022 American Transplant Congress
Utilizing Microporous Annealed Particle (MAP) Gel as an Immunomodulatory Carrier for Islet Delivery
M. Ma¹, P. Chhabra¹, C. Roosa², D. R. Griffin², K. L. Brayman¹
¹Department of Surgery, University of Virginia Health System, Charlottesville, VA, ²Department of Biomedical Engineering, University of Virginia Health System, Charlottesville, VA
*Purpose: To investigate if coating with MAP gel improves dissociated or whole islet transplantation outcome.*Background: MAP gel platform technology is composed of hydrogel microspheres that…
2022 American Transplant Congress
Allogenic Cardiac Progenitor Cells Transplantation with Immune Suppressant Cyclosporine a Recovers Myocardial Infarction in Rodent Model
M. Gunasekaran, R. Mishra, S. Sharma, P. Saha, L. Chen, S. Guru, A. Stefanowicz, A. Bilewska, S. Zarinebaf, G. Zhi-Dong, S. Kaushal
Pediatrics, Lurie Childrens Hospital, Chicago, IL
*Purpose: Cardiac progenitor cells (CPCs) are well-characterized stem cell type shown to potentiate cardiac regeneration in myocardial infarct (MI) model. However, auto and allo immune…
2022 American Transplant Congress
Cd47 Expression on Transplanted Human Neonatal Mesenchymal Stem Cells Inhibits Phagocytosis in Rat Myocardial Infarction Model
M. Gunasekaran, R. Mishra, S. Sharma, P. Saha, L. Chen, S. Guru, A. Stefanowicz, A. Bilewska, S. Zarinebaf, G. Zhi-Dong, S. Kaushal
Lurie Childrens Hospital, Chicago, IL
*Purpose: Immune rejection of transplanted stem/progenitor cells is a major stumbling block in designing effective therapy for myocardial infarction (MI). Human neonatal mesenchymal stem cells…
2022 American Transplant Congress
Overexpression of Human Ectonucleoside Triphosphate Diphosphohydrolase 1 (entpd1; Hcd39) Did Not Afford Significant Protection on Porcine Endothelial Cells
R. Matheson¹, B. Gonzalez Nolasco¹, K. Deng¹, R. Garofalo¹, N. Serifis¹, T. M. Coe¹, C. Rhatigan¹, D. Gil¹, D. Cloonan¹, K. Lee¹, K. Hall², M. Youd², J. F. Markmann¹, S. C. Robson³
¹Transplantation surgery research, Massachusetts General Hospital, Boston, MA, ²eGenesis Bio, Cambridge, MA, ³Beth Israel Deaconess Medical Center, Boston, MA
*Purpose: The thromboregulatory and anti-inflammatory potential of human CD39 (hCD39) makes it a gene of interest in xenotransplantation. In porcine endothelium, CD39 activity is generally…
2022 American Transplant Congress
Prospective Evaluation of Donor-Derived Cell-Free DNA (dd-cfDNA) in Monitoring Response to Anti-Rejection Treatment in Kidney Transplant Recipients with Indication Biopsy
L. Benning¹, A. Fink², F. Kälble¹, C. Speer¹, C. Nusshag¹, M. Zeier¹, C. Süsal³, C. Morath¹, T. Tran²
¹Department of Nephrology, University Hospital Heidelberg, Heidelberg, Germany, ²Transplantation Immunology, Institute of Immunology, University Hospital Heidelberg, Heidelberg, Germany, ³Transplant Immunology Research Center of Excellence, Koç University Hospital, Istanbul, Turkey
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) is a marker of allograft injury in kidney transplant recipients (KTR). Little is known about the possible use of dd-cfDNA…
2022 American Transplant Congress
Development of a Culturally Sensitive Chatbot to Inform Living Donor Candidates of African Ancestry About Apol1 Genetic Testing
E. J. Gordon¹, P. Waite², J. Gacki-Smith², D. Duquette³, A. Agrawal¹, J. Friedewald¹, S. Savage⁴, E. Simmons⁵, M. Cooper⁶, A. Gilbert⁶, C. Wicklund⁷
¹Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Center for Health Services and Outcomes Research, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Invitae, Inc, San Francisco, CA, ⁵Invitae, San Francisco, CA, ⁶Surgery, Georgetown University Medical Center, Washington, DC, DC, ⁷Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: Living kidney donor candidates of African ancestry are increasingly asked to undergo Apolipoprotein L1 (APOL1) genetic testing to better understand their risk of kidney…
2022 American Transplant Congress
Incidence of Dapsone-Induced Methemoglobinemia in Solid Organ Transplant Recipients
D. Quan¹, R. Gordon¹, J. Lee¹, D. Khoshabafard², A. Han¹
¹Pharmacy, UCSF Medical Center, San Francisco, CA, ²Clinical Phamacy, UCSF School of Pharmacy, San Francisco, CA
*Purpose: The purpose of this study was to determine the incidence of dapsone-induced methemoglobinemia in solid organ transplant recipients.*Methods: This was a single-center retrospective cohort…
2022 American Transplant Congress
Early Outcomes of Single Dose Eculizumab for Abo-Incompatible Living Donor Renal Transplantation
K. Heagler, M. Campara, P. Di Cocco, S. Gaitonde, I. Tang, J. Almario Alvarez, M. Spaggiari, J. Benken, C. S. Muran, B. Valdepenas, D. Pierce, I. Tzvetanov, E. Benedetti
UI Health, Chicago, IL
*Purpose: Use of ABO-incompatible (ABOi) donors increases access to living donor renal transplantation (LDRT). Conventional desensitization with plasmapheresis (PLEX) allows safe ABOi transplantation when pre-transplant…
2022 American Transplant Congress
Manufactured Organ Procurement Facility Collaboration and Authorization Approach for Xenotransplant Research
E. P. Weldon, N. S. Lawson, B. E. Sullivan, B. S. Parent, C. L. Deterville, R. A. Dieter, R. A. Montgomery
NYU Langone Health-Transplant Institute, New York, NY
*Purpose: A Manufactured Organ Research Facility (MORF) was created at our institution to provide a safe environment for testing xenograft organs in deceased brain dead…
2022 American Transplant Congress
Liver Transplant Recipient History of Criminality: Impact on Clinical Outcomes
M. M. French¹, R. Mangus¹, R. Holmes¹, A. Krause¹, J. Sumner¹, C. Kubal¹, B. Ekser², P. Mihaylov³, A. Lutz⁴, J. Fridell⁵
¹Department of Surgery, Indiana University, Indianapolis, IN, ²Surgery, Indiana University - Transplant Surgery, Indianapolis, IN, ³Department of Surgery, Indiana Univ School of Medicine, Indianapolis, IN, ⁴Department of Surgery, Indiana University, Fishers, IN, ⁵Department of Surgery, Indiana University School of Medicine, Indianapolis, IN
*Purpose: Health disparities are present in transplantation, just as in other areas of medicine. This is a retrospective review of liver transplant (LT) recipients to…