Am J Transplant, Volume 22, Suppl 3 Archives - Page 70 of 190 - ATC Abstracts

2022 American Transplant Congress
Analysis and Outcomes of Liver Re Transplantation After Initial DCD Liver Transplantation
A. Kadimella¹, J. Eason², R. Helmick², J. Vanatta²
¹HPB and Liver Transplantation, AIG Hospitals, Hyderabad, India, ²University of Tennessee/Methodist Transplant Institute, Memphis, TN
*Purpose: DCD livers were more prone for ischemic cholangiopathy and graft failure than DBD livers due to multi factorial reasons. With all the available data…
2022 American Transplant Congress
Single-Cell CyTOF Profiling of Pediatric Immune Responses to Organ Transplantation Reveals a Novel Subpopulation of T Cells Significantly Correlating with Graft Health
M. Rao¹, M. Amouzgar¹, J. T. Harden¹, M. Lapasaran¹, A. Trickey¹, B. Armstrong², J. Odim³, T. Debnam³, C. Esquivel¹, S. C. Bendall¹, O. Martinez¹, S. M. Krams¹
¹Stanford University, Palo Alto, CA, ²Rho, Durham, NC, ³National Institutes of Health, Bethesda, MD
*Purpose: Solid organ transplant is lifesaving for children with end-stage heart, liver, or kidney disease. Protection of the transplanted organ from rejection requires long-standing immunosuppression.…
2022 American Transplant Congress
Post-Kidney Transplant Body Mass Index Trajectories Are Associated with Graft Loss and Mortality
Y. Liu¹, V. Bendersky¹, X. Chen¹, M. Harhay², D. Segev¹, M. McAdams-DeMarco¹
¹Johns Hopkins University, Baltimore, MD, ²Drexel University, Philadelphia, PA
*Purpose: Early post-kidney transplantation (KT) changes in physiology, medications, and health stressors likely impact body mass index (BMI). Hence, we sought to estimate trajectories of…
2022 American Transplant Congress
Outcomes of Kidney Transplant Recipients with Covid-19 in Singapore Treated with Sotrovimab in the Era of the Delta Variant
M. R. D'Costa¹, H. K. Sran¹, E. Wong¹, Z. Chang², Y. Chua², J. Somani³, L. Lum³, A. Vathsala¹
¹National University Centre for Organ Transplantation, National University Hospital, Singapore, Singapore, ²Medicine, National University Hospital, Singapore, Singapore, ³Infectious Diseases, National University Hospital, Singapore, Singapore
*Purpose: Kidney transplant recipients (KTRs) are at higher risk for severe COVID-19 caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Sotrovimab decreases the risk…
2022 American Transplant Congress
Outcomes of COVID-19 in Solid Organ Transplant Recipients in Canada 2020-2021: A Prospective, Multicenter Cohort Study
V. G. Hall¹, G. Alahmadi², J. T. Solera², T. Marinelli², H. Cardinal³, G. Prasad⁴, S. A. De Serres⁵, D. Isaac⁶, R. Mainra⁷, C. Lamarche⁸, R. Sapir-Pichhadze⁹, S. Gilmour¹⁰, A. Humar², D. Kumar²
¹University Health Network/Toronto General Hospital, Toronto, ON, Canada, ²UHN, Toronto, ON, Canada, ³UMontreal, Montreal, QC, Canada, ⁴StMH, Toronto, ON, Canada, ⁵Laval U, Quebec, QC, Canada, ⁶UCalgary, Calgary, AB, Canada, ⁷USaskatchewan, Saskatoon, SK, Canada, ⁸HMR, Montreal, QC, Canada, ⁹McGill U, Montreal, QC, Canada, ¹⁰SCH, Edmonton, AB, Canada
*Purpose: To understand the outcomes and changes in disease severity of COVID-19 in Solid Organ Transplant (SOT) recipients over time in the context of therapeutic…
2022 American Transplant Congress
Proteinuria in Diseased Kidney Transplant Donors for Prediction of Chronic Lesions in Pre-Transplant Biopsies – A Prospective Observational Study
F. Haupenthal¹, J. Kläger², F. Bauernfeind³, A. Heinzel¹, K. Doberer¹, K. Mayer¹, L. Naar¹, M. Eigenschink¹, K. Hu¹, H. Regele², T. Szekeres⁴, R. Reindl-Schwaighofer¹, G. Bond¹
¹Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria, ²Department of Pathology, Medical University of Vienna, Vienna, Austria, ³Department of Learning, Informatics, Management and Ethics, Karolinska Institute, Stockholm, Sweden, ⁴Division of Clinical Chemistry, Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria
*Purpose: Pre-transplant kidney graft biopsies have been suggested for organ quality assessment. Data on the association between donor proteinuria and organ quality of deceased donors…
2022 American Transplant Congress
Autophagy is an Important Factor in the Development of Fibrosis Following Renal Injury; Implications for Post-Transplant IFTA
R. Lopez-Soler¹, X. Ding², Q. Zang³
¹Tansplant, Surgery, Edward Hines VA Medical Center, Hines, IL, ²Pathology, Loyola University Medical Center, Maywood, IL, ³Surgery, Loyola University Medical Center, Maywood, IL
*Purpose: Interstitial Fibrosis and Tubular Atrophy (IFTA) is the most common cause of long-term graft failure following renal transplant. There is currently no effective therapy.…
2022 American Transplant Congress
Dynamic Changes and Roles of Specialized Pro-resolving Lipid Meditators in the Initiation and Resolution Process of Lung Ischemia-Reperfusion Injury in Rats
H. Oda¹, S. Tanaka¹, M. Shinohara², Y. Morimura¹, Y. Yokoyama¹, H. Kayawake¹, Y. Yamada¹, A. Ohsumi¹, D. Nakajima¹, H. Date¹
¹Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto City, Japan, ²The Integrated Center for Mass Spectrometry, Kobe University Graduate School of Medicine, Kobe City, Japan
*Purpose: Lung ischemia-reperfusion injury (IRI) is one of the significant complications after lung transplantation, which is a form of acute lung injury by robust inflammation.…
2022 American Transplant Congress
Deceased Donor Procurement Biopsy Practices, Interpretation, and Histology-Based Decision Making: A Survey of US Transplant Centers
V. Fleetwood¹, D. Axelrod², Y. Caliskan¹, H. Randall¹, J. Wellen³, M. Lichtenberger³, C. Dedert¹, R. Rothweiler⁴, G. F. Marklin⁴, D. Brockmeier⁴, M. A. Schnitzler¹, S. A. Husain⁵, S. Mohan⁵, B. Kasiske⁶, M. Cooper⁷, K. L. Lentine¹
¹Saint Louis U., St. Louis, MO, ²U. of Iowa, Iowa City, IA, ³WUSTL, St. Louis, MO, ⁴Mid-Am. Trans., St. Louis, MO, ⁵Columbia U., New York, NY, ⁶Hennepin Healthcare, Minneapolis, MN, ⁷MedStar Transpl. Inst., Washington, DC
*Purpose: In light of contemporary controversies on the utility of kidney procurement biopsies in predicting allograft outcomes and guiding organ acceptance, we surveyed transplant providers…
2022 American Transplant Congress
The Role Of Ferroptosis In Modulating Ischemia Reperfusion Injury(IRI) Gene Expression In Marginal Donor Livers(MDLS) Using The Novel Protect Normothermic Perfusion Pump
M. D. Nazzal¹, K. Kurashima², J. Bettag², A. Chen², S. Bruno², A. Nagarapu², J. Van Nispen¹, J. Krebs², J. Teckman², D. Carpenter³, D. Hermelin³, C. Varma¹, A. Jain²
¹Surgery, Saint Louis University, Saint Louis, MO, ²Pediatrics, Saint Louis University, Saint Louis, MO, ³Pathology, Saint Louis University, Saint Louis, MO
*Purpose: Severe IRI can impair liver allograft when using MDLs and accounts for high discard rates. We tested iron chelators to reduce ferroptosis and IRI.…