2022 American Transplant Congress
Fibroblastic Reticular Cell Lama4 Regulates T Cell Migration to Lymph Nodes and Adaptive Immunity
1Surgery, UMB, Baltimore, MD, 2Harvard University, Boston, MA
*Purpose: Lymph node (LN) stromal laminin α4 (Lama4) is associated with tolerance. We hypothesized that fibroblastic reticular cell (FRC) derived Lama4 contributes to a tolerogenic…2022 American Transplant Congress
Brief Human IL-2 Mutein Therapy Induces Foxp3+ T-Regulatory Cell Expansion and Donor-Specific Allograft Tolerance
*Purpose: New therapeutic approaches to the management of transplant recipients are warranted in efforts to improve outcomes.*Methods: We have engineered a modified human IL-2 protein…2022 American Transplant Congress
Trends on Organ Transplantation and Donation Based on Public Sentiments Expressed in Social Media Comments in Korea: Text Mining Analysis
Department of Surgery, Kyung Hee University, College of Medicine, Seoul, Korea, Republic of
*Purpose: The shortage of deceased organ donation is a challenge for most countries. In the media era, the role of social media is becoming important…2022 American Transplant Congress
Donor-Specificb Cell Dysfunction and Suppressive Ability Are Differentially Induced in Cob-Mediated Transplantation Tolerance
*Purpose: B cells in mice tolerized to fully mismatched heart allografts with anti-CD154+donor spleen cells (CoB) are intrinsically dysfunctional and unable to differentiate into germinal…2022 American Transplant Congress
Metastatic BK Virus-Associated Urothelial Carcinoma Originating in Renal Allograft
1Pathology, UT Southwestern, Dallas, TX, 2Internal Medicine, UT Southwestern, Dallas, TX
*Purpose: Cases of urinary tract carcinoma associated with BK virus have been reported in kidney transplant recipients; therefore, we postulate that BK virus may play…2022 American Transplant Congress
Liver Transplantation is Beneficial Regardless of Cirrhosis Stage or Acute-on-Chronic Liver Failure Grade: A Single-Center Experience
*Purpose: Liver transplantation for the most critically ill remains controversial; however, it is currently the only curative treatment option. The aim of this study was…2022 American Transplant Congress
Extended Duration of Rabbit Antithymocyte Globulin (rATG) Induction in Kidney and Kidney/Pancreas Transplant Recipients
Temple University Hospital, Philadelphia, PA
*Purpose: Many transplant centers have endorsed an expanded duration of rabbit antithymocyte globulin (rATG) in the outpatient setting through peripheral administration to help minimize cost.…2022 American Transplant Congress
OPO Education Spending and Donation Rates
*Purpose: The shortage of organs for transplantation in the United States has endured for decades despite the efforts of transplantation professionals, organ procurement organizations, volunteer…2022 American Transplant Congress
Tolerance of Allogeneic Kidneys with Durable (>200 Days) Multilineage Chimerism and Bone Marrow Engraftment in Cynomolgus Macaques
*Purpose: We have previously reported that a regimen including anti-CD3 immunotoxin, 45 days of cyclosporine, and pre-transplant total body irradiation (TBI) promoted tolerance of kidney…2022 American Transplant Congress
Development of an M2 Macrophage Signature in Spontaneously Accepted Kidney Allografts
*Purpose: Kidney allografts transplanted across certain mouse strain combinations (e.g. DBA/2 to B6) are spontaneously accepted. We have recently shown that novel regulatory Tertiary Lymphoid…
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