ATC Abstracts

American Transplant Congress abstracts

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  • 2022 American Transplant Congress

    Artificial Mitochondria Transfer to Mitigate Ischemic Damage in an In Vitro Model of Tubular Injury and in an Ex Vivo Porcine Model of DCD Renal Transplantation

    A. Rossi1, S. Sedrakyan2, F. Montali3, C. Aardena4, N. Abraham5, A. Barbas5, L. N. Byers6, C. Palles7, A. Asthana6, J. Robertson4, L. Perin2, R. Senger4, B. Bussolati1, G. Orlando8

    1Un. of Turin, Turin, Italy, 2Children Hospital, Los Angeles, CA, 3Un. of L'Aquila, L'Aquila, Italy, 4VA Tech, Blacksburg, VA, 5Duke, Durham, NC, 6WFIRM, Winston Salem, NC, 7University of Florida, Gainesville, FL, 8Wake Forest Baptist, Winston-Salem, NC

    *Purpose: We aimed at assessing whether artificial mitochondrial transfer (AMT) mitigates renal injury in an in vitro model of tubular damage and in an ex…
  • 2022 American Transplant Congress

    Engineered IL-2 Plus Calcineurin Inhibitor Synergistically Expands Regulatory T Cells Transduced with Engineered IL-2 Receptor and Facilitates Establishment of Transplantation Tolerance

    T. Hirai1, P. Lin2, T. L Ramos2, K. Garcia3, R. S Negrin2

    1Urology, Tokyo Women's Medical University, Tokyo, Japan, 2Blood and Marrow Transplantation, Stanford University, Stanford, CA, 3Molecular and Cellular Physiology and Structural Biology, Stanford University, Stanford, CA

    *Purpose: Clinical trials for regulatory T cell (Treg) therapy in organ transplant has shown promising results. However, it is still under the debate which drugs…
  • 2022 American Transplant Congress

    Tolerant B Cells Suppress Memory B Cells in a Donor Specific Manner in CoB Mediated Transplantation Tolerance

    S. Durgam1, D. Yin1, M. Alegre2, A. Chong1

    1Surgery, section of transplant immunology, University of Chicago, Chicago, IL, 2Medicine, section of rheumatology, University of Chicago, Chicago, IL

    *Purpose: We previously reported that B cells in recipients made tolerant to fully mismatched heart allografts by anti-CD154+donor spleen cells (CoB) become dysfunctional in their…
  • 2022 American Transplant Congress

    De Novo Fibrinogen Alpha Chain Amyloidosis in Kidney Allograft

    T. Khaja1, L. Truong2, G. Nassar1

    1Nephrology, Houston Methodist Hospital, Houston, TX, 2Pathology, Houston Methodist Hospital, Houston, TX

    *Purpose: Amyloidosis is a disorder characterized by tissue deposition of misfolded proteins that can lead to organ damage such as renal failure. There are multiple…
  • 2022 American Transplant Congress

    Galectin-3 Expression in Autoimmune Hepatitis

    N. Limon-de la Rosa1, C. Moreno-Ramírez2, E. Cervantes-Alvarez3, D. Yoeli4, I. Vasic4, M. Kriss5, C. A. Huang4, N. Navarro-Alvarez1

    1Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, 2Universidad de Guadalajara , Centro Universitario de la Costa., Puerto Vallarta Jalisco, Mexico, 3Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, 4University of Colorado Anschutz Medical Campus, Denver, CO, 5University of Colorado Anschutz Medical Campus, Aurora, CO

    *Purpose: Autoimmune hepatitis (AIH) is characterized by chronic inflammation in which healthy liver cells are targeted by one’s immune system. The persistent inflammatory milieu can…
  • 2022 American Transplant Congress

    Long-Term Low-Dose Corticosteroid Therapy Can Suppress Calcineurin Inhibitor Induced Nephrotoxicity without Steroid-Related Complication in Living Kidney Transplant Recipient

    H. Sasaki, H. Harada, D. Takamoto, Y. Takada, S. Harada, H. Tanaka

    Sapporo City General Hospital, Sapporo, Japan

    *Purpose: The induction of calcineurin inhibitors (CNI) greatly reduced the rate of allograft rejection, although their chronic use resulted in vascular inflammation in kidney transplant…
  • 2022 American Transplant Congress

    Left Digit Bias in Selection and Acceptance of Deceased Donor Organs

    C. E. Jacobson1, C. S. Brown2, K. H. Sheetz3, S. A. Waits2

    1University of Michigan Medical School, Ann Arbor, MI, 2Department of Surgery, University of Michigan, Ann Arbor, MI, 3Department of Surgery, University of California San Francisco, San Francisco, CA

    *Purpose: Organs suitable for donation are a scarce resource and maximizing the use of available donor organs is a public health priority. Transplantable organs may…
  • 2022 American Transplant Congress

    A FRET-Based Technique to Quantify Foxp3 Acetylation in TREG

    F. F. Gonzalez1, G. Vilanova2, M. Fribourg1

    1Icahn School of Medicine at Mount Sinai, New York, NY, 2Universitat Politècnica de Catalunya-BarcelonaTech, Barcelona, Spain

    *Purpose: Foxp3 acetylation is essential to TREG stability and function. Acetylation protects Foxp3 from degradation, and acetylated Foxp3 translocates to the nucleus to activate the…
  • 2022 American Transplant Congress

    Single Port Robotic Extraperitoneal Kidney Transplantation: Technical Aspects

    A. Kaviani, J. Kaouk, M. Abou Zeinab, A. Beksac, E. Ferguson, Y. Lin, D. Goldfarb, A. Wee, M. Eltemamy

    Cleveland Clinic, Cleveland, OH

    *Purpose: To provide, in a video format, tips and tricks for surgical steps of the single-port robotic extraperitoneal kidney transplantation.*Methods: Thirteen patients underwent single-port robotic…
  • 2022 American Transplant Congress

    PFIC- Outcome and Time to Transplant After Biliary Diversion According to Genetic Subtypes

    M. Schulze1, A. Sahloul2, E. Lainka3

    1Organ Transplant Centre of Excellence, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia, 2Department of General, Visceral and Transplant Surgery, University Hospital Essen, Essen, Germany, 3Department of Pediatric Gastroenterology, University Hospital Essen, Essen, Germany

    *Purpose: Progressive familial intrahepatic Cholestasis (PFIC) is a heterogeneous autosomal recessive disease characterized by progressive cholestasis, pruritus leading to liver injury. Surgical therapy aims in…
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