Am J Transplant, Volume 22, Suppl 3 Archives - Page 66 of 190 - ATC Abstracts

2022 American Transplant Congress
Ikaros-SIRT1 Signaling Axis Regulates Macrophage Pyroptosis and Ischemia-Reperfusion Injury (IRI) in Mouse and Human Liver Transplantation
K. Kadono¹, H. Hirao¹, H. Kojima¹, K. J. Dery¹, X. Li², J. Kupiec-Weglinski¹
¹UCLA Medical Center, Los Angeles, CA, ²NIEHS, Durham, NC
*Purpose: Although Ikaros is a well-established regulator of lymphopoiesis, its role in myeloid cells and organ IRI remains unclear. We recently reported that the SIRT1-mediated…
2022 American Transplant Congress
Donor-Specific T Cell Senescence In Operationally Tolerant Liver Transplant Recipients
K. Deng¹, N. Tanimine², C. Breeden³, B. Burrell³, G. Gaile³, K. Lee¹, R. Matheson¹, F. Qiang¹, C. Rickert¹, C. LeGuern¹, J. Markmann¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Department of Gastroenterological and Transplantation Surgery, Hiroshima University, Hiroshima, Japan, ³Immune Tolerance Network, Bethesda, MD
*Purpose: Recent evidence indicates a correlation in liver transplant recipients between successful operational tolerance (OT) post immunosuppression withdrawal (ISW) with both recipient age and time…
2022 American Transplant Congress
Computer vs Human-Based Prediction and Stratification of the Risk of Long-Term Kidney Allograft Failure
G. Divard¹, M. Raynaud¹, V. Tataputii², B. Abdalla³, C. Legendre¹, C. Lefaucheur¹, O. Aubert¹, A. Loupy¹
¹Paris Transplant Group, Paris, France, ²NYU Langone Health, New York, NY, ³UCLA, Los Angeles, CA
*Purpose: Clinical decision-making process after transplantation is mainly driven by patient individual risk of allograft failure prediction assessed by physicians. However, this task remains difficult…
2022 American Transplant Congress
Superiority of Renal Transplantation in ESRD Management Over Long Term Dialysis in Octogenerians
s. karhadkar, J. Kolansky, K. Wirshup, A. Gregor, J. Dawes, A. DiCarlo
Temple University Hospital, Philadelphia, PA
*Purpose: In the last 2 decades there has been an increase in the number of patients aged 65 years and older who were placed on…
2022 American Transplant Congress
Antibody and Cellular Immunity After Primary mRNA Vaccination in Adolescents with Stable Liver or Liver-Inclusive Intestine Allografts
G. Mazariegos¹, C. Ashokkumar², K. Soltys², M. Michaels², G. Bond², A. Khanna², M. Ningappa², P. Morgan², R. Sindhi²
¹UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, ²Childrens Hospital of Pittsburgh of UPMC, Pittsburgh, PA
*Purpose: Transplant recipients experience lower seroconversion rates after COVID-19 vaccination compared with healthy adults and have been prioritized to receive booster doses. To assess pre-…
2022 American Transplant Congress
Noninvasive Biomarkers for Allograft Monitoring After Intestinal Transplantation: Promising Early Results from a Novel Peptide, REG3α
C. P. Smullin¹, R. S. Venick², E. A. Marcus², B. V. Naini³, D. G. Farmer⁴
¹David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, ²Pediatrics, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, ³Pathology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, ⁴Surgery, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA
*Purpose: There is an urgent need for the discovery and application of noninvasive biomarkers to detect allograft rejection after intestinal transplantation (ITx). Calprotectin and citrulline…
2022 American Transplant Congress
Sigma-1 Receptor Agonists Are Protective in a Rat Model of Kidney Transplantation
A. Hosszu¹, T. Lakat¹, A. Toth¹, J. Hodrea¹, L. Wagner², A. J. Szabo¹, A. Fekete¹
¹1st Department of Pediatrics, Semmelweis University, Budapest, Hungary, ²Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary
*Purpose: Kidney transplantation (Tx) is associated with better long-term outcomes and quality of life compared to dialysis, but the shortage in donor organs is serious…
2022 American Transplant Congress
Neuropilin-2 is a Novel Checkpoint Inhibitor That is Required for Long-Term Allograft Survival
J. Wedel, S. Kong, K. Liu, N. Kochupurakkal, D. Bala, D. Bielenberg, H. Nakayama, D. M. Briscoe
Boston Children's Hospital, Boston, MA
*Purpose: We have previously reported that Neuropilin (NRP) 2-associated signaling events modulate PI3K/mTOR/Akt activity in several human cell lines. While intrinsic NRP1 activity has been…
2022 American Transplant Congress
Personalized Medicine Using Next-Generation Sequence for Kidney Transplant Recipients
J. Sanchez-Garcia, D. Morris, E. Darling, M. Dantis-Tan, J. Olson, K. Gaid, A. Raza, S. Anand
Intermountain Medical Center, Murray, UT
*Purpose: Tissue diagnosis definitely drives therapeutic and prognostic decisions amongst patients with chronic kidney disease (CKD). However, patients with CKD often present late in the…
2022 American Transplant Congress
Vitamin D Deficiency in Liver Transplant Recipients
V. Subramanian¹, T. Lippert², J. Buggs¹, N. Kemmer¹, K. Dhanireddy¹
¹Transplant Institute, Tampa General Hospital, Tampa, FL, ²University of South Florida, Tampa, FL
*Purpose: Patients with chronic liver disease are at risk of nutritional deficiency. The goal of this study was to determine the prevalence of vitamin D…