2022 American Transplant Congress
Donor-Derived Cell-Free DNA Across the Spectrum of Solid Organ Transplantation
1Baylor Scott & White Health, Temple, TX, 2CareDx, Inc, Brisbane, CA
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) is a robust and clinically useful analyte initially validated for kidney allograft surveillance. Emerging data support the utility of dd-cfDNA…2022 American Transplant Congress
Everolimus Alleviates Renal Allograft Interstitial Fibrosis by Inhibiting Epithelial to Mesenchymal Transition Not Only via Inducing Autophagy but Also via Stabilizing iκB-α
*Purpose: Chronic allograft dysfunction (CAD) is the major cause of late graft loss in long-term renal transplantation. In our previous study, we found Epithelial-mesenchymal transition…2022 American Transplant Congress
Impact of a Transplant Pharmacy Collaborative Practice Agreement Implementation on an Institutional Medication Assistance Program Funding Utilization
*Purpose: Post-transplant medication cost can pose a significant barrier for patient adherence and graft outcomes. Strategic selection of medication agent is often challenging and requires…2022 American Transplant Congress
Histologic Borderline Reflects Molecular Injury Not Rejection: Results from the Trifecta Study
*Purpose: In the Trifecta study (NCT04239703), we recently compared indication biopsy diagnoses (MMDx and histology) and plasma %dd-cfDNA levels for indication biopsies (JASN in press…2022 American Transplant Congress
Wide Spectrum of Molecular Injury Highlights Heterogeneity of Banff Tubulitis and Interstitial Inflammation Lesions
*Purpose: The pathological definition and clinical significance of borderline T cell-mediated rejection (BL-TCMR) remains an area of active debate, leading to inconsistencies in therapeutic strategy.…2022 American Transplant Congress
Correlation of Donor-Derived Cell-Free DNA with Histology and Molecular Diagnoses of T-cell Mediated Rejection in Kidney Transplant Biopsies
1Virginia Commonwealth University, Richmond, VA, 2University of Alberta, Edmonton, AB, Canada
*Purpose: We have reported the correlation of donor-derived cell-free DNA (dd-cfDNA) with histologic and molecular diagnosis (MMDx) of kidney transplant biopsies (Gupta et al, Transplantation…2022 American Transplant Congress
Conversion from Immediate to Extended-Release Tacrolimus (LCP-Tac) Six Months After Renal Transplantation Optimizes Safety and Efficacy
*Purpose: LCP-Tac is a once daily formulation of tacrolimus indicated for prevention of rejection in kidney transplant recipients (KTRs) that may have less variability and…2022 American Transplant Congress
Medical Necessity Kidney Donation in the Treatment Algorithm for Nutcracker Syndrome: Transforming Pain to Altruism
Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT
*Purpose: Patients with nutcracker syndrome (NCS) are often presented with multiple treatment pathways, including interventional and surgical options. In those who elect native nephrectomy, consideration…2022 American Transplant Congress
Identifying Health System-Level Barriers to Living Donor Kidney Transplantation: A Cross-Sectional Survey of Health Professionals
1McGill University, Montreal, QC, Canada, 2University of Montreal, Montreal, QC, Canada
*Purpose: There is growing recognition that efforts to increase living donor kidney transplantation (LDKT) should focus on health system-level inefficiencies. While previous studies focused on…2022 American Transplant Congress
Cold Pulsatile Perfusion of Donor Kidneys Varies Significantly by Procuring Organ Procurement Organization Indicating Both Over and Underutilization of This Preservation Method
Kidney Transplant, Ascension Sacred Heart Hospital, Pensacola, FL
*Purpose: To assess the usage and variability cold pulsatile perfusion preservation in the United States based on procuring organ procurement organization (OPO).*Methods: All donors procured…
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