2022 American Transplant Congress
NK Cells in Kidney Allograft Antibody-mediated Rejection Display Increased Proliferation, IL-21 Responsiveness, Type-1 Activation, and Cytotoxic Profile
*Purpose: The role of NK cell during antibody-mediated rejection (ABMR) has been previously recognized, but an in-depth characterization of pathways that contribute to such immune…2022 American Transplant Congress
Heterogeneity in Center Practices in Liver Transplantation for Alcohol-Associated Liver Disease in the United States
*Purpose: Alcohol-associated liver disease (ALD) is now the leading indication for liver transplantation (LT) in the United States (US), particularly since LT has emerged as…2022 American Transplant Congress
Resource Expenditure in the Evaluation of Older Donors for Heart Transplant: An Impediment to Donor Pool Expansion?
*Purpose: Using older donors for heart transplant (HT) could alleviate donor scarcity but the resource implications of this strategy - and whether evaluation of older…2022 American Transplant Congress
Development of a Dynamic Map of Peripheral Myeloid Cells Associated with Acute Rejection of Vascularized Composite Tissue Allografts
*Purpose: Myeloid cells are involved in early alloactivation in response to organ allografts and can initiate acute rejection. The heterogeneity of myeloid populations and the…2022 American Transplant Congress
A Signature of Tolerance Which Identifies Subclinical Rejection-Free Patients at One Year After Kidney Transplantation
*Purpose: Spontaneous and rare cases of patients undergoing a functional renal transplant in the absence of immunosuppression represent a particular situation of immune tolerance. We…2022 American Transplant Congress
Perioperative IL-6 Blockade Promotes Intra-Graft Regulation and Prevents Costimulation-Blockade Resistant Rejection
*Purpose: Our group has recently shown that CTLA4-Ig monotherapy leads to limited murine heart allograft survival associated with decreased Treg frequencies and early acute T-cell…2022 American Transplant Congress
Possible Recurrence Must Not Limit Kidney Transplantations for Patients with Focal Segmental Glomerulosclerosis
Istituto Giannina Gaslini, Genova, Italy
*Purpose: Non-genetic forms of Focal Segmental Glomerulosclerosis (FSGS) are at high risk of recurrence after kidney transplant (KT) (55%), when compared to inherited forms (0-4%)…2022 American Transplant Congress
Normothermic Machine Perfusion (NMP) Improves Access to Transplantation for Late Liver Re-Transplant Candidates
*Purpose: Late liver re-transplantation (LLrT) is a complex surgical procedure. Candidates for LLrT spend longer on the waitlist than primary transplant candidates due to selectivity…2022 American Transplant Congress
Tacrolimus and Mycophenolic Acid Therapeutic Exposure Targets in Black and White Kidney Transplant Recipients
1Univeristy at Buffalo/SUNY, Buffalo, NY, 2Ohio State Medical Center, Columbus, OH
*Purpose: Tacrolimus and Mycophenolic Acid(MPA), the preferred immunosuppressive regimen for kidney transplant recipients(KTR), exhibit interpatient pharmacokinetic variability which may impact allograft survival in Black and…2022 American Transplant Congress
Longitudinal Characterization of the Microvirome in a Cohort of Renal Transplant Recipients
*Purpose: The selective targeting of T cells in transplant immunosuppression medications leads to a high rate of viral infections, with different immunosuppression regimens resulting in…
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