2022 American Transplant Congress
Sigma-1 Receptor Agonists Are Protective in a Rat Model of Kidney Transplantation
*Purpose: Kidney transplantation (Tx) is associated with better long-term outcomes and quality of life compared to dialysis, but the shortage in donor organs is serious…2022 American Transplant Congress
Neuropilin-2 is a Novel Checkpoint Inhibitor That is Required for Long-Term Allograft Survival
Boston Children's Hospital, Boston, MA
*Purpose: We have previously reported that Neuropilin (NRP) 2-associated signaling events modulate PI3K/mTOR/Akt activity in several human cell lines. While intrinsic NRP1 activity has been…2022 American Transplant Congress
Personalized Medicine Using Next-Generation Sequence for Kidney Transplant Recipients
Intermountain Medical Center, Murray, UT
*Purpose: Tissue diagnosis definitely drives therapeutic and prognostic decisions amongst patients with chronic kidney disease (CKD). However, patients with CKD often present late in the…2022 American Transplant Congress
Vitamin D Deficiency in Liver Transplant Recipients
1Transplant Institute, Tampa General Hospital, Tampa, FL, 2University of South Florida, Tampa, FL
*Purpose: Patients with chronic liver disease are at risk of nutritional deficiency. The goal of this study was to determine the prevalence of vitamin D…2022 American Transplant Congress
Optimal Dose of Anti-Thymocyte Globulin to Improve Allograft and Patient Survival After Kidney Transplantation: Analysis from Korean Organ Transplantation Registry Data
Surgery, Asan Medical Center, Seoul, Seoul, Korea, Republic of
*Purpose: The optimal dose of anti-thymocyte globulin (ATG) as an induction regimen in Asian kidney recipients is unclear.*Methods: Using Korean Organ Transplantation Registry database, we…2022 American Transplant Congress
Early Impact of the Mission Act on Utilization of Veterans Affairs Transplant Centers
*Purpose: The Veterans Affairs (VA) Maintaining Systems and Strengthening Integrated Outside Networks (MISSION) Act of 2018 was implemented in 2019 to increase veteran access to…2022 American Transplant Congress
Infiltrating CD8+ Cytotoxic T Cells Are Converted to a Regulatory Phenotype in Accepted Kidney Allografts
*Purpose: Mouse kidney allografts are spontaneously accepted in select, fully-mismatched donor-recipient strain combinations (i.e. DBA/2J to C57BL/6 (B6)) without any immunosuppressive drug treatment. We have…2022 American Transplant Congress
Donor-Derived Duodenal Adenocarcinoma of a Bladder-Drained Pancreas Allograft
*Purpose: Donor-derived malignancies are rare but frequently present with aggressive pathology and high mortality rates [PMID 32627325]. The urologic literature demonstrates an increased risk of…2022 American Transplant Congress
Characteristics and Outcomes of Patients Admitted for Acute Alcoholic Hepatitis Before and During the COVID-19 Pandemic
*Purpose: Despite known increases in alcohol use, changes in alcohol-associated liver disease rates during COVID-19 have not been well characterized. We compared the incidence and…2022 American Transplant Congress
Monitoring Efficacy of Tocilizumab Treatment for Chronic Antibody Mediated Rejection (cAMR) in Kidney Transplants Using Donor-Derived Cell-Free DNA (dd-cf-DNA)
*Purpose: IL-6/IL-6R have emerged as important targets for treating cAMR. Recent data show that long-term treatment can stabilize eGFR, reduce DSAs and result in a…
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