Am J Transplant, Volume 22, Suppl 3 Archives - Page 60 of 190 - ATC Abstracts

2022 American Transplant Congress
Single Dose Alemtuzemab Provides Comparable Rejection Free and Infection Free Survival Compared to Double Dose Alemtuzumab. In Comparison to Alemtuzemab, Basiliximab Has Superior Infection Free Graft Survival. Results from a Steroid Sparing Transplant Group
H. Sharma, A. Odugoudar, B. Devkaran, A. Rao, A. El-Bakry, T. Gunawardhane, D. Ridgway, M. Howse, S. Mehra
Department of Transplant Surgery, Royal Liverpool University Hospital, Liverpool, United Kingdom
*Purpose: The present study investigated the short-term biopsy-proven acute rejection rates and viral infection rates amongst our protocol of single-dose Alemtuzemab (Cohort 1) versus double…
2022 American Transplant Congress
Defining the Longitudinal Dynamics of Immune Cells in Blood in the First Year After Pediatric Liver Transplantation (pLTx)
E. Chichelnitskiy¹, L. Ruhl², I. Goldschmidt³, A. Karch⁴, L. Antiga⁵, D. Debray⁶, L. Hierro⁷, D. Kelly⁸, V. McLin⁹, E. Nicastro¹⁰, J. Pawlowska¹¹, P. Czubkowski¹¹, R. Mikolajczyk¹², U. Baumann¹³, C. Falk¹⁴
¹Institute of Transplant Immunology, Hannover Medical School (MHH), Hannover, Germany, ²Institute of Transplant Immunology, MHH, Hannover, Germany, ³Division of Pediatric Gastroenterology and Hepatology, MHH; European Paediatric Liver Transplantation Network, Hannover, Germany, ⁴Research Group Epidemiological and Statistical Methods, Helmholtz Centre for Infection Research; German Center for Infection Research, TTU-IICH Hannover; Institute for Epidemiology and Social Medicine, University of Münster, Münster, Germany, ⁵Hannover; Ospedali Riuniti di Bergamo, Bergamo, Italy, ⁶Hannover; Hôpital Necker-Enfants Malades, Paris, France, ⁷Hannover; Hospital Infantil Universitario La Paz, Madrid, Spain, ⁸Birmingham Children's Hospital, Birmingham, United Kingdom, ⁹Service Spécialités Pédiatriques, Genève, Switzerland, ¹⁰Ospedali Riuniti di Bergamo, Bergamo, Italy, ¹¹Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, The Children’s Memorial Health Institute, Warsaw, Poland, ¹²German Center for Infection Research, TTU-IICH Hannover; MHH; Institute of Medical Epidemiology, Biostatistics and Medical Informatics, University of Halle, Halle, Germany, ¹³Birmingham Children’s Hospital, UK; Division of Pediatric Gastroenterology and Hepatology, MHH, Hannover, Germany, ¹⁴Institute of Transplant Immunology, MHH; German Center for Infection Research, TTU-IICH, Hannover, Germany
*Purpose: In the European multicentre “ChilSFree” study we aimed for a deep characterisation of the longitudinal immune dynamics during the first year after pLTx.*Methods: Absolute…
2022 American Transplant Congress
PD-1 Expression on CD8+ T Cells Contributes to the Establishment of Mixed Chimerism-Based Operational Tolerance
C. J. Little, S. C. Kim, J. Fechner, J. Post, M. Winslow, D. B. Kaufman
Surgery, University of Wisconsin, Madison, WI
*Purpose: PD-1 is a T cell co-inhibitory molecule involved in T cell exhaustion and antigen specific hypo-reactivity. Given the role of PD-1 signaling in the…
2022 American Transplant Congress
Clinical Impact of a Modified Lung Allocation Score That Mitigates Selection Bias
E. M. Schnellinger¹, E. Cantu², D. E. Schaubel¹, S. E. Kimmel³, A. J. Stephens-Shields¹
¹University of Pennsylvania, Philadelphia, PA, ²Hospital of the University of Pennsylvania, Philadelphia, PA, ³University of Florida, Gainesville, FL
*Purpose: The U.S. lung allocation system uses the Lung Allocation Score (LAS) to prioritize lung transplant candidates. Selection bias, induced by dependent censoring of waitlisted…
2022 American Transplant Congress
Evaluation of Different Initial Tacrolimus Dosing Regimens in Pediatric Post-Liver Transplantation
A. F. Alghanem¹, A. Alsmari¹, H. Joharji²
¹Pharmaceutical Care, King Abdulaziz Medical City, Riyadh, Saudi Arabia, ²Pharmaceutical Care, King Faisal Specialized Hospital and Research Center, Riyadh, Saudi Arabia
*Purpose: Tacrolimus is an immunosuppressant used in post-liver transplantation, has wide pharmacokinetic variability, particularly in pediatric patients. Therefore, this study aimed to evaluate different weight-based…
2022 American Transplant Congress
Circulating and Intragraft Donor (HLA)-Specific B Cells Drive Allograft Rejection After Kidney Transplantation
A. Torija¹, N. Bolaños¹, L. Donadeu¹, M. Meneghini², I. Torres², A. Gabaldon², M. Gomà³, E. Crespo¹, F. Moreso⁴, O. Bestard²
¹Vall d'Hebron Research Institute (VHIR), Barcelona, Spain, ²Vall d'Hebron University Hospital, Barcelona, Spain, ³Bellvitge University Hospital, Barcelona, Spain, ⁴Vall d'Heron University Hospital, Barcelona, Spain
*Purpose: Besides donor-specific antibodies (DSA), circulating donor(HLA)-specific memory B cells (mBc) have also shown to play a deleterious role driving antibody-mediated rejection (ABMR) in kidney…
2022 American Transplant Congress
Regulatory T Cells Suppress Memory IFN-Gamma Production in Highly Sensitised Patients
C. Dudreuilh¹, S. Basu¹, O. Shaw², H. Burton¹, C. Domingo-Vila¹, T. Tree¹, G. Lombardi¹, C. Scotta¹, A. Dorling¹
¹King's College London, London, United Kingdom, ²Viapath Clinical Transplantation Laboratory, Guy's Hospital, London, United Kingdom
*Purpose: Highly sensitized patients (HS) present worse long-term outcome after transplantation compared to those without donor-specific antibodies (DSA). It has been suggested that desensitisation using…
2022 American Transplant Congress
Local Intragraft Humoral Immune Response in Chronic Lung Allograft Dysfunction
E. Miyamoto¹, S. C. Juvet², D. Vosoughi², J. Wang², J. Al-Refaee², T. Daigneault², A. Duong², S. Moshkelgosha², S. Keshavjee², K. Tinckam², A. Chruscinski³, D. Hwang⁴, T. Martinu²
¹Tenri Hospital Japan, University Health Network Canada, Nara, Japan, ²University Health Network, Toronto, ON, Canada, ³Multi-Organ Transplantation, University Health Network, Toronto, ON, Canada, ⁴Sunnybrook Health Science Centre, Toronto, ON, Canada
*Purpose: Donor HLA-specific antibody (DSA) and antibody against self-antigens (self-antigen antibody) can cause injury and lead to chronic lung allograft dysfunction (CLAD) after lung transplantation…
2022 American Transplant Congress
Cognitive Impairment In Liver Transplant Recipients 6 Months Or More After Transplant
K. Berry¹, L. Gaynor¹, F. Barry¹, E. Tsoy¹, C. Goode¹, R. Wong¹, S. Erlhoff¹, L. VandeVrede¹, K. Possin¹, J. C. Lai²
¹University of California, San Francisco, San Francisco, CA, ²University of California San Francisco, San Francisco, CA
*Purpose: Patients with decompensated cirrhosis awaiting liver transplant (LT) exhibit a spectrum of neurocognitive disorders, largely attributed to hepatic encephalopathy (HE) and considered reversible after…
2022 American Transplant Congress
Ixazomib for Desensitization (IXADES): Results of a Phase II Clinical Trial
N. Wilson¹, S. R. Reese², L. Ptak³, F. Aziz², S. Parajuli², V. Jucaud⁴, S. Denham⁴, A. Mishra⁵, P. Hematti⁵, A. Djamali²
¹University of Wisconsin, Madison, WI, ²Medicine, University of Wisconsin, Madison, WI, ³Administration, University of Wisconsin, Madison, WI, ⁴Terasaki Institute, Los Angeles, CA, ⁵UW Comprehensive Cancer Center, University of Wisconsin, Madison, WI
*Purpose: Ixazomib is a second-generation oral proteasome inhibitor, FDA approved for the treatment of refractory multiple myeloma. The purpose of the study was (1) to…