2022 American Transplant Congress
Fcγ Receptor-Positive Cells Play a Critical Role in Rejection of Allogeneic Bone Marrow Cells Mediated by Anti-Donor Antibodies
1Talaris, Louisville, KY, 2Talaris Therapeutics, Louisville, KY
*Purpose: Sensitization through prior exposure to MHC antigens results in an increased rate of graft rejection. We previously reported that humoral immunity is the primary…2022 American Transplant Congress
Assessment of Letermovir as Universal Prophylaxis for Cytomegalovirus Infection in Lung Transplant Recipients
*Purpose: Cytomegalovirus (CMV) poses a significant concern in the post-operative management of lung transplant (LT) recipients. Current recommended prophylactic strategies with ganciclovir (GCV) or valganciclovir…2022 American Transplant Congress
A Population-Based Analysis of Long-Term Outcomes Following Pediatric Acute Liver Failure Highlights High Risk Populations in Access to Transplant
*Purpose: Pediatric acute liver failure (PALF) is a potentially devastating illness that affects otherwise healthy children. Nearly 70% of children with PALF will recover, while…2022 American Transplant Congress
Marginal Zone Phenotype B Cells Are Required for Formation of Donor-Specific IgG After Allogeneic Sensitization
Department of Pathology, Johns Hopkins University, Baltimore, MD
*Purpose: The formation of allogeneic antibody directed against non-self MHC, termed donor-specific antibody (DSA), is a significant barrier to successful transplant outcomes. Pre-formed DSA limits…2022 American Transplant Congress
Regulatory T Cells Suppress Memory IL-17a Production in Highly Sensitised Patients with End-Stage Renal Disease
*Purpose: Highly sensitised patients exhibit poorer long-term outcomes following renal transplantation compared to those non sensitised individuals. IL17-A has been associated with acute rejection. Presence…2022 American Transplant Congress
Center-Level Variation in Transplantation Practice Following Acuity Circles Policy Change
*Purpose: Although early studies suggest that the Acuity Circles (AC) allocation policy has reduced disparities in access to deceased donor liver transplants (DDLTs), changes in…2022 American Transplant Congress
Natural Antibodies Are Associated With Rejection And Long-term Renal Allograft Loss In A Multi-center International Cohort
*Purpose: Potentially harmful non-donor-specific human leukocyte antigen antibodies have been identified in renal transplantation, including natural IgG antibodies (Nabs) reactive to varied antigenic structures.*Methods: In…2022 American Transplant Congress
Impact of Immunosuppressive Medications on SARS-CoV-2 Vaccination Response in Kidney Transplant Patients
*Purpose: The COVID-19 pandemic portends significant morbidity and mortality in immunocompromised individuals. Vaccination against COVID-19 among immunocompromised population is an essential step to minimize deadly…2022 American Transplant Congress
Collaboration for Successful Transition to Adult Care in Liver Transplant: Early Outcomes of a Structured Program with Youth Engagement
*Purpose: To effectively transition youth to adult hepatology through a structured program and developed partnerships while promoting and maintaining optimal outcomes.*Methods: The pediatric and adult…2022 American Transplant Congress
Immunomodulatory Effects of Probiotic Bifidobacterium Bifidum with Tacrolimus and Sirolimus in Mouse Skin Graft Model
*Purpose: Accumulating evidence suggests that gut microbiota actively crosstalks with the host immune system, and alterations of gut microbiota may exert immune regulatory effects. We…
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