Am J Transplant, Volume 22, Suppl 3 Archives - Page 56 of 190 - ATC Abstracts

2022 American Transplant Congress
Role of Innate Immunity in Regulating Host Responses to Ischemia and Reperfusion and Allograft Rejection Injury in Vascularized Composite Allotransplantation
S. Han¹, X. Lai², J. Wang¹, L. VanOsdol³, C. Chen¹, J. Mathew¹, J. R. Leventhal⁴, Z. Zhang⁵
¹Northwestern University, Chicago, IL, ²Comprehensive Transplant Center, Microsurgery Core, Northwestern University, Chicago, IL, ³Comprehensive Transplant Center, Northwestern University, Chicago, IL, ⁴Surgery, Northwestern Medicine, Chicago, IL, ⁵Northwestern University Transplant Surgery, Chicago, IL
*Purpose: Vascularized composite tissue allotransplantation (VCA) 's wide application has been impeded by deleterious side-effect of current immunosuppressive regimens. This study is aimed to determine…
2022 American Transplant Congress
Novel Drug Target Identified for Reversal of Renal Tubular Injury
S. Sur, M. Kerwin, S. Pineda, M. Sarwal
UCSF, San Francisco, CA
*Purpose: Understanding the unique susceptibility of the human kidney tubule to oxidative cell stress and to identify compounds to support reversal of renal tubular damage.*Methods:…
2022 American Transplant Congress
Donor Factors Do Not Discriminate Living Donor Kidney Transplant Outcomes and Should Not Be Used to Promote the Use of Compatible Pairs in Kidney Paired Donation Programs
G. Irish¹, D. Chang², S. Chadban¹, N. Boudville¹, S. Campbell¹, J. Kanellis¹, L. McMichael², E. Sharples³, M. Kadatz², J. Gill², P. Clayton¹
¹ANZDATA, Adelaide, Australia, ²Providence Health Research Institute, Transplant Research, Vancouver, BC, Canada, ³Oxford University Trust Hospital, Oxford, United Kingdom
*Purpose: Enrolment of ABO blood group and HLA incompatible pairs in kidney paired donation programs improves matching potential. The benefit for compatible pairs, however, is…
2022 American Transplant Congress
Does Black Race Modify the Risk of Transplant Failure Associated with HLA Mismatch in First Adult Kidney Allografts from Deceased Donors?
K. Atiemo
Tulane University, New Orleans, LA
*Purpose: Current US- based data suggests Black patients awaiting kidney re-transplantation are more likely to be highly sensitized compared to other races. Degree of HLA…
2022 American Transplant Congress
Acute Cellular Rejection in Liver Transplant Recipients Following Vaccination Against Covid-19
R. Sarwar¹, O. Adeyi², N. Lim¹
¹Division of Gastroenterology, Hepatology and Nutrition, University of Minnesota, Minneapolis, MN, ²Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN
*Purpose: The coronavirus disease 2019 (COVID-19) global pandemic has seen the development of effective vaccines in record time. We report a series of five liver…
2022 American Transplant Congress
DonorNet Procurement Photos and Their Association with Kidney Utilization
M. Stuart¹, A. M. Placona¹, C. Martinez¹, K. Andreoni²
¹United Network for Organ Sharing, Richmond, VA, ²University Hospitals, Case Western University, Cleveland, OH
*Purpose: Procurement teams can upload backbench photos of organs to DonorNet. It is unclear if these photos are associated with kidney utilization. We examined the…
2022 American Transplant Congress
National Consortium Registry Insights on Management and Outcome of Hepatitis C Viremic Heart Transplants
R. Gottlieb¹, M. Salem¹, A. Ravichandran², J. Kennedy³, J. Strope⁴, S. Lin⁵, J. Chow⁶, P. Eckman⁷, S. Desai⁸, O. Larkins¹, J. Vanzyl¹, S. Hall¹
¹Baylor Scott & White Healthcare, Dallas, TX, ²Ascension Medical Group, Indianapolis, IN, ³Inova Heart and Vascular Institute, Falls Church, VA, ⁴Medical University of South Carolina, Charleston, SC, ⁵University of Washington Medical Center, Seattle, WA, ⁶Tufts Medical Center, Boston, MA, ⁷Minneapolis Heart Institute, Minneapolis, MN, ⁸Ochsner Medical Center, New Orleans, LA
*Purpose: Multicenter US registry of clinical management of HCV NAT+ hearts.*Methods: An ongoing 8-center retrospective IRB-approved registry collected baseline characteristics, labs, management, and outcomes after…
2022 American Transplant Congress
Microvascular Inflammation in Kidney Transplant Biopsies in the Absence of HLA-DSA Displays Intense Cytotoxic T-cell and NK Cell but Not Plasma Cell Infiltration
A. Buxeda¹, L. Llinàs-Mallol¹, J. Gimeno², D. Redondo-Pachón¹, C. Arias-Cabrales¹, C. Burballa¹, A. Puche², M. Pérez-Sáez¹, J. Pascual³, M. Crespo¹
¹Nephrology Department, Hospital del Mar, Institute Mar for Medical Research (IMIM), Barcelona, Spain, ²Pathology Department, Hospital del Mar, Institute Mar for Medical Research (IMIM), Barcelona, Spain, ³Nephrology Department, Hospital Universitario 12 de Octubre. Institute Mar for Medical Research (IMIM), Madrid, Spain
*Purpose: Microvascular inflammation (MVI) without evidence of HLA-donor-specific antibodies (HLA-DSA) or C4d+ deposition remains an enigmatic phenotype, which cannot be classified as antibody-mediated rejection (ABMR)…
2022 American Transplant Congress
Immunity Rates to Hepatitis B Among Solid Organ Transplant Recipients
S. Kopf¹, J. Walker², K. Bruxvoort³, H. Budhwani³, A. Nellore⁴
¹Infectious Disease, University of Alabama at Birmingham Hospital, Birmingham, AL, ²University of Alabama at Birmingham, Birmingham, AL, ³University of Alabama at Birmingham Hospital, Birmingham, AL, ⁴University of Alabama, Birmingham, AL
*Purpose: Immunosuppression after transplantation decreases vaccine responsiveness. Thus, to be best protected from post-transplant communicable diseases, vaccination of organ transplant candidates in the pre-transplant period…
2022 American Transplant Congress
A Novel Approach to Non-Invasive Multimodality Testing with Allosure and Allomap Predicts Microvascular Inflammation with High Accuracy in Kidney Transplant Recipients
S. Parajuli, F. Aziz, N. Garg, S. E. Panzer, K. Van Hyfte, K. Degner, S. Reese, L. Ptak, N. Wilson, A. Djamali
University of Wisconsin, Madison, WI
*Purpose: The most prominent histologic lesion in antibody-mediated rejection (ABMR) is microvascular inflammation (MVI); however, its recognition and scoring can be challenging and poorly reproducible…