2022 American Transplant Congress
Implementing Clinical Decision Support Tools for Immunosuppressant Drug-Drug Interactions to Prevent Graft Failure
1MAPMG, Mc Lean, VA, 2Kaiser Permanente, Silver Spring, MD, 3MAPMG, Rockville, MA
*Purpose: Immunosuppressant drug-drug interactions can result in immunosuppressant toxicity or subtherapeutic levels causing rejection. If not identified and managed appropriately, these interactions may result in…2022 American Transplant Congress
Normothermic Ex Vivo Pancreas Perfusion for the Preservation of Porcine Pancreas Grafts
*Purpose: The purpose of this study was to develop a stable porcine model for normothermic ex-vivo pancreas perfusion (NEVPP) for the preservation of grafts with…2022 American Transplant Congress
Sirolimus Use Is Associated With An Improved Immune Response To Covid-19 Vaccination In Kidney Transplant Recipients
*Purpose: Kidney transplant recipients (KTRs) are highly vulnerable to severe COVID-19, however are poorly protected by vaccination. Additional vaccine doses have achieved limited improvements in…2022 American Transplant Congress
Exploring Individual Optimal Immunosuppression Management According to the Oncological Risk in Liver Transplanted Patients with Hepatocellular Carcinoma
*Purpose: Post-Liver transplant (LT) immunosuppression management is the only modifiable factor to prevent hepatocellular carcinoma (HCC) recurrence; however, the impact of immunosuppression on the HCC…2022 American Transplant Congress
A2/A2B to B Kidney Transplantation Outcomes: A Single-Center 5 Year Experience
Vanderbilt University Medical Center, Nashville, TN
*Purpose: The new kidney allocation system (KAS) instituted in 2014 allowed organ procurement organizations to allocate A2/A2B to B candidates preferentially was meant to improve…2022 American Transplant Congress
Case-Control Study of Belatacept as Maintenance Immunosuppression in Kidney Transplant Recipients Living with HIV
Yale School of Medicine, New Haven, CT
*Purpose: Belatacept has been increasingly used in kidney transplant recipients (KTR) as a calcineurin-inhibitor (CNI) sparing agent. There are little data on belatacept use in…2022 American Transplant Congress
Demographic Characteristics of VCA Candidates and Recipients in the U.S.
1Research, UNOS, Richmond, VA, 2Office of the Chief Medical Officer, UNOS, Richmond, VA
*Purpose: As with other fields of transplantation, it is important to understand the populations VCA transplantation is serving.*Methods: This study used OPTN VCA waiting list…2022 American Transplant Congress
HLA-DRB1 and DQB1 Amino Acid Mismatches as Determinants of Kidney Allograft Failure
*Purpose: It was previously reported that HLA-DRB1 amino acid (AA) mismatches (MMs) at peptide-binding pockets of this molecule account for significant incremental risk of kidney…2022 American Transplant Congress
Mass Cytometry Reveals Single-cell Kinetics Of Cytotoxic Lymphocyte Evolution In Cmv-infected Renal Transplant Patients
*Purpose: Cytomegalovirus (CMV) infection is associated with graft rejection in renal transplantation. Memory-like NK cells expressing NKG2C and lacking FcεRIγ are established during CMV infection.*Methods:…2022 American Transplant Congress
Cold Stress-Induced Ferroptosis in Liver Sinusoidal Endothelial Cells Deteriorates Liver Transplant Outcomes
UCLA Medical Center, Los Angeles, CA
*Purpose: While hepatocytes are affected by ischemia-reperfusion injury (IRI) especially under normothermic stress, liver sinusoidal endothelial cells (LSECs) are particularly vulnerable to cold storage-induced IR-insult.…
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