2022 American Transplant Congress
Use of De Novo mTOR Inhibitors in Highly Sensitized Kidney Transplant Recipients
*Purpose: mTOR inhibitors (mTORi) allow calcineurin-inhibitor reduction without loss of efficacy and may improve allograft-transplant outcomes. However, the safety of this protocol in high-immunological risk…2022 American Transplant Congress
Developing A Tool To Assess Psychosocial Determinants Of Health And Quality Of Life In Pediatric Liver Transplant Patients
*Purpose: Psychosocial assessment prior to liver transplantation is essential to ensure that caregivers and pediatric patients are adequately prepared for this complex process. There are…2022 American Transplant Congress
Increased Risk for Allograft Loss in African American Kidney Transplant Recipients After Biopsy for Chronic Allograft Dysfunction
*Purpose: Chronic allograft dysfunction (CGD) is the first sign of a “troubled kidney”. CGD was defined as >25% increase in serum creatinine relative to a…2022 American Transplant Congress
Single Cell Transcriptomics Reveal Allograft Immune Cell Patterns Associated with Histological Features of Acute Cellular Rejection in Liver Transplantation
*Purpose: Development of successful tolerance induction strategies using immune cell-based therapies in transplantation depends on improved understanding of the local intra-graft cellular milieu that underlies…2022 American Transplant Congress
Antibody Response and Molecular Graft Surveillance in Kidney Transplant Recipients Following Sars-CoV-2 Vaccination
1Transplant Institute, NYU Langone Health, New York, NY, 2CareDx, Brisbane, NY
*Purpose: Preliminary studies suggest that kidney transplant recipients (KTRs) show diminished humoral responses to SARS-CoV-2 vaccination. Although reports of allograft rejection after SARS-CoV-2 vaccination have…2022 American Transplant Congress
Inflammation After Kidney Transplantation Is Associated With Overall- And Death-censored Graft Loss
Department of Transplantational Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway
*Purpose: Early graft loss after kidney transplantation (KT) is mainly a result of acute rejection, while long-term graft loss episodes are often dependent on multifactorial…2022 American Transplant Congress
Single Blind Randomized Controlled Trial Comparing BNT162b2 Vs JNJ-78436735 Vaccine As An Additional Dose After Two Doses Of BNT162b2 Vaccine In Solid Organ Transplant (SOT) Recipients
*Purpose: Even though a high efficacy and immunogenicity of COVID-19 vaccines have been reported in the general population, vaccine immunogenicity is suboptimal in SOT recipients…2022 American Transplant Congress
Single Nuclei RNA-Sequencing Identifies Distinct Immune Cell Profile in Kidney Allograft Fibrosis
*Purpose: A major obstacle after kidney transplantation (KT) is chronic allograft dysfunction characterized by interstitial fibrosis and tubular atrophy (IFTA). Despite extensive research, the cellular…2022 American Transplant Congress
Modification of Gut Microbiota Accelerates Kidney Repair After Experimental Ischemia Reperfusion Injury
Johns Hopkins Medicine, Baltimore, MD
*Purpose: Kidney ischemia reperfusion injury (IRI) leads to changes in gut microbiome, and pre-IR microbiome changes can modify course of experimental tissue injury. There is…2022 American Transplant Congress
Clusterin Protects Kidney Transplants from Ischemia-Reperfusion Injury by Modulating Neutrophil Infiltration
*Purpose: Ischemia-reperfusion injury (IRI) is inevitable during organ transplantation. Clusterin (CLU) has shown to be protective in IRI. Supplementation of storage solution with recombinant CLU…
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