Am J Transplant, Volume 22, Suppl 3 Archives - Page 48 of 190 - ATC Abstracts

2022 American Transplant Congress
Binding Mechanisms For Donor Dc-derived Exosomes To Cross-dress Of Recipient Dc
L. ZHANG¹, X. LI¹, J. LIU¹, H. WEI¹, C. LI¹, A. HUANG², C. ZHENG¹, Q. LIU¹
¹Department of Biochemistry, Southern University of Science and Technology, Shenzhen, China, ²Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
*Purpose: Our previous evidence suggests donor dendritic cell (DC)-derived exosomes cross-dress recipient DC after heart transplantation in mice. This process plays a critical role in…
2022 American Transplant Congress
Dynamic Risk Prediction of Kidney Graft Failure After Deceased Donor Transplant
D. G. Hu¹, H. Thiessen Philbrook¹, S. Mohan², I. Hall³, M. Doshi⁴, K. F. Kerr⁵, C. R. Parikh¹
¹Johns Hopkins University, Baltimore, MD, ²Columbia University Medical Center, New York, NY, ³University of Utah, Salt Lake City, UT, ⁴University of Michigan, Ann Arbor, MI, ⁵University of Washington, Seattle, WA
*Purpose: Identifying kidney transplant recipients at risk of graft failure allows for early intervention in clinical care. We developed a dynamic risk prediction model based…
2022 American Transplant Congress
18 Month Review of Liver Acuity Circles Allocation
J. Foutz¹, S. Noreen¹, M. Cafarella¹, A. Wilk¹, J. Trotter², S. Biggins³, J. Pomposelli⁴
¹United Network for Organ Sharing, Richmond, VA, ²Baylor University Medical Center, Dallas, TX, ³University of Washington, Seattle, WA, ⁴University of Colorado, Aurora, CO
*Purpose: Acuity circles (AC) allocation was implemented on 2/4/2020 with a goal of removing DSA and region from liver allocation and broadening the distribution of…
2022 American Transplant Congress
Increased Waitlist Mortality in Pediatric Liver Transplant Candidates with Greater Distance from Transplant Center
C. X. Qin, T. Ishaque, S. M. Frey, A. B. Massie, A. M. Cameron, D. L. Segev, E. A. King
Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Greater distance from transplant center in adult liver transplant (LT) candidates is associated with increased waitlist mortality. Pediatric LT candidates have higher waitlist mortality…
2022 American Transplant Congress
25 Years of a Standardized Living Donor (LD) Intestinal Transplant Technique – What Has Been Achieved?
R. Gruessner¹, A. C. Gruessner²
¹SUNY Downstate Medical Center, Brooklyn, NY, ²SUNY Downstate Medical Center, Brooklyn, MA
*Purpose: The indication for intestinal transplantation (ITX) is irreversible intestinal failure with dependence on total parenteral nutrition (TPN). Most intestinal transplants are from deceased donors…
2022 American Transplant Congress
Perfusate Metabolites and Association with Pump Perfusion and Allograft Failure
R. X. Liu¹, N. Koyawala², H. T. Philbrook², I. Hall³, P. Reese⁴, S. Mohan⁵, M. Doshi⁶, C. Parikh¹
¹Johns Hopkins University School of Medicine, Baltimore, MD, ²Department of Medicine, Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD, ³University of Utah School of Medicine, Salt Lake City, UT, ⁴University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ⁵University of Columbia Vagelos College of Physicians & Surgeons, New York, NY, ⁶University of Michigan, Ann Arbor, MI
*Purpose: While hypothermic machine perfusion (HMP) is associated with improved kidney graft viability, the exact biological mechanisms underlying this association are unknown. The goal of…
2022 American Transplant Congress
Intrinsic DEPTOR Activity Modulates Treg Subset Differentiation
J. Wedel¹, M. Maslyar¹, B. Alsairafi¹, S. Kong², D. M. Briscoe¹
¹Transplant Research Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, ²Computational Health Informatics Program, Boston Children's Hospital, Harvard Medical School, Boston, MA
*Purpose: We have previously reported that DEPTOR activity within CD4+Foxp3+ Tregs increases immunomodulation following transplantation. DEPTOR functions by both stabilization of Foxp3 expression through epigenetic…
2022 American Transplant Congress
Influence of Immunosuppressive Drugs on Nk Cells in Therapeutic Drug Exposured
R. r. Qin¹, C. Sun², B. Nashan¹
¹Division of Life and Medicine, University of Science and Technology of China/The First affiliated hospital of University of Science and Technology of China, Hefei, China, ²Division of Life and Medicine, University of Science and Technology of China, Hefei, China
*Purpose:Natural killer (NK) cells as part of the innate immune system are residing in the liver and are considered to be main regulators in alloimmune…
2022 American Transplant Congress
Risk Factors for Extubation Failure Post- Lung Transplantation
A. J. Trindade¹, W. D. Gannon¹, A. G. Dragnich¹, G. Dahlberg¹, C. T. Demarest², E. S. Lambright², K. A. McPherson¹, S. G. Norfolk¹, C. M. Shaver¹, I. M. Robbins¹, M. Bacchetta²
¹Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, ²Thoracic Surgery, Vanderbilt University Medical Center, Nashville, TN
*Purpose: Extubation delays following lung transplantation can result in delirium, deconditioning, infections, and increased hospital length of stay. Risk stratifying patients for extubation failure may…
2022 American Transplant Congress
Plasmapheresis Dependent AT1R Antibody Associated Recurrent FSGS After Living Donor Kidney Transplantation
R. K. Mallavarapu
Transplant Nephrology, Augusta University - Medical College of Georgia, Augusta, GA
*Purpose: Antibodies against Angiotensin II type 1 receptors (AT1R-Abs) may predispose to podocyte injury, glomerular endotheliosis and proteinuria. The management of AT1R-Ab associated recurrent FSGS…