Am J Transplant, Volume 22, Suppl 3 Archives - Page 47 of 190 - ATC Abstracts

2022 American Transplant Congress
Early Clinical Complications Following HLA-Incompatible Living Donor Kidney Transplantation
J. D. Motter¹, K. Jackson¹, A. Massie¹, J. Garonzik-Wang², D. Segev¹
¹Johns Hopkins University, Baltimore, MD, ²University of Wisconsin-Madison, Madison, WI
*Purpose: Incompatible living donor kidney transplant recipients (ILDKTr) require desensitization to facilitate transplantation across donor-specific antibody (DSA); however, this substantial upfront immunosuppression may result in…
2022 American Transplant Congress
Conversion to Belatacept for Calcineurin Inhibitor Toxicities
S. S. Patel, P. Jadav, M. Sekulic, S. Kudose, I. Batal, S. Mohan, R. Crew
Columbia University Medical Center, New York, NY
*Purpose: Calcineurin inhibitors (CNIs) have improved renal transplant (RTx) outcomes but are associated with significant toxicities. Belatacept provides better long-term outcomes than cyclosporine, has less…
2022 American Transplant Congress
Outcomes of Primary Simultaneous Pancreas-Kidney Transplants by Induction Agent in the United States
A. Cerise¹, T. Shaker¹, K. Ramanathan¹, S. Jackson², R. Kandaswamy¹, S. Riad³
¹Surgery, University of Minnesota, Minneapolis, MN, ²Analytics, MHealth-Fairview, Minneapolis, MN, ³Medicine, University of Minnesota, Minneapolis, MN
*Purpose: Induction immunosuppression choice for simultaneous pancreas-kidney (SPK) transplants varies widely in the United States. We examined the association between induction agents and outcomes of…
2022 American Transplant Congress
Navigating the Ethics of Transplant Research Involving Newly Deceased
B. Parent¹, T. Schiff², E. Weldon³, N. Lawson⁴, S. Mehta⁵, R. A. Montgomery⁶
¹Medical Ethics, NYU Grossman School of Medicine, New York, NY, ²Medical Ethics, NYU School of Medicine, New York, NY, ³NYU Langone Health-Transplant Institute, New York, NY, ⁴NYU Langone Transplant Institute, New York, NY, ⁵New York University Langone Transplant Institute, New York, NY, ⁶NYU Langone, New York, NY
*Purpose: The most promising innovations for overcoming the organ shortage include novel organ sources such as xenotransplant and bioengineered organs. Studying these organs in mechanically…
2022 American Transplant Congress
External Validation of the Abbreviated Ibox Scoring System at One-Year Post Kidney Transplant as a Surrogate Endpoint for Death-Censored Graft Survival
A. Klein¹, L. Kosinski², R. Muse², A. Loupy³, O. Aubert³, G. Divard³, M. Stegall⁴, I. Helanterä⁵, W. E. Fitzsimmons¹, I. O'Doherty¹
¹Transplant Therapeutics Consortium, Critical Path Institute, Tucson, AZ, ²Critical Path Institute, Tucson, AZ, ³Paris Transplant Group, Paris, France, ⁴Mayo Clinic, Rochester, MN, ⁵Helsinki University Hospital, Helsinki, Finland
*Purpose: The Transplant Therapeutics Consortium seeks to translate the iBox from Loupy et al., 2019 into a surrogate endpoint for five-year death-censored graft survival after…
2022 American Transplant Congress
Performance of Race-Independent GFR Estimating Formulas, CKD-EPI₂₀₂₁and NMR-GFR Post Kidney Transplantation
E. Schiffer¹, F. Stammler², M. Grassi², E. Schiffer²
¹Clinical Research, numares Group Corporation, Boston, MA, ²Research and Development, numares AG, Regensburg, Germany
*Purpose: Progressive GFR decline post kidney transplantation is a general problem that requires accurate assessment of GFR for clinical decision making. The gold-standard radiotracer determined…
2022 American Transplant Congress
CIAT: A New Kidney Exchange Program with Better Options for Highly Sensitized and Long Waiting Patients
M. d. Klerk¹, J. Kal¹, D. L. Roelen², M. Betjes¹, A. Weerd de¹, M. Reinders¹, M. Kho¹, K. Glorie³, J. I. Roodnat¹
¹Internal Medicine, Erasmus MC Transplant Institute, Rotterdam, Netherlands, ²Immunology, Leids UMC, Netherlands, ³Econometrics, EUR, Rotterdam, Netherlands
*Purpose: A number of alternative, both living and deceased donor kidney transplant programs have been developed for incompatible pairs and difficult to match patients. The…
2022 American Transplant Congress
Racial Equity in Living Donor Kidney Transplant: Center Variation and Opportunities for Progress
L. M. McElroy, T. Schappe, S. Peskoe, V. Wang, D. Mohottige, C. D. Scales, J. Pendergast, L. Boulware
Duke University, Durham, NC
*Purpose: To estimate racial differences in living donor kidney transplant (LDKT) rates relative to patient, center and regional characteristics that may influence access to transplant.*Methods:…
2022 American Transplant Congress
Reduced Enterohepatic Recirculation of Mycophenolate and Lower Blood Concentrations Are Associated with the Stool Bacterial Microbiome
P. A. Jacobson¹, A. Saqr¹, B. Carlson¹, C. Staley², A. Rashidi³, S. Holtan³, M. Al-Kofahi¹, T. Kaiser², M. MacMillan⁴, J. Young⁵, N. El Jurdi³, D. Weisdorf³, A. Khoruts⁶
¹Univ of MN, College of Pharmacy, Minneapolis, MN, ²Univ of MN, Dept of Surgery, Minneapolis, MN, ³Univ of MN, Divison of Heme/Onc Transplant, Minneapolis, MN, ⁴Univ of MN, Pediatric Heme/Onc Transplant, Minneapolis, MN, ⁵Univ of MN, Divison of Infectious Diseases, Minneapolis, MN, ⁶Univ of MN, Division of Gastroenterology, Hepatology and Nutrition, Minneapolis, MN
*Purpose: Mycophenolate mofetil (MMF) is an important immunosuppressant used after allogeneic hematopoietic cell transplant (HCT). Blood concentrations of mycophenolic acid (MPA) are highly variable and…
2022 American Transplant Congress
Blood Transcriptomes of Covid-19 Infected Kidney Recipients Demonstrate Frequent and Persistent Sars-cov-2 Virome Gene Expression
Z. Sun¹, M. M. Rana², A. C. Reghuvaran³, Y. A. Azzi⁴, G. Carrara⁵, S. Hartzell⁶, S. Kulkarni³, W. Zhang⁶, K. Banu³, P. Heeger⁶, E. Akalin⁴, P. Cravedi⁶, Z. Zhang⁷, M. C. Menon³
¹Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, ²Infectious Disease Director, Icahn School of Medicine at Mount Sinai, New York, NY, ³Nephrology, Yale University, New Haven, CT, ⁴Nephrology, Montefiore Medical Center, New York, NY, ⁵Clinical Research Coordinator, Icahn School of Medicine at Mount Sinai, New York, NY, ⁶Icahn School of Medicine at Mount Sinai, New York, NY, ⁷Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Kidney transplant recipients (KTRs) have poor outcomes vs non-KTRs with acute COVID-19. To provide insight into management of immunosuppression during acute COVID-19, we studied…