Am J Transplant, Volume 22, Suppl 3 Archives - Page 46 of 190 - ATC Abstracts

2022 American Transplant Congress
Assessing Proportion of Days Covered (PDC) of Mycophenolate (MCP) Prescriptions in Post Kidney Transplant (KT) Recipients as a Predictor of Clinical Outcomes
K. Sandlin¹, T. Sam¹, N. Wilson¹, A. Yango², B. Fischbach³, A. Dao¹
¹Pharmacy, Baylor University Medical Center, Dallas, TX, ²Baylor All Saints Medical Center, Dallas Nephrology Associates, Fort Worth, TX, ³Baylor University Medical Center, Dallas Nephrology Associates, Dallas, TX
*Purpose: Nonadherence to medications following KT is a risk factor for adverse outcomes. PDC is an objective measure of adherence obtained through retail prescription records…
2022 American Transplant Congress
Kidney Allocation System Promotes Racial Equality Not Equity in Access to Deceased Donor Kidney Transplantation
C. Killian¹, B. Shelton¹, P. MacLennan¹, M. McLeod¹, A. Carter¹, R. Reed¹, H. Qu¹, B. Orandi¹, V. Kumar¹, D. Sawinski², J. Locke¹
¹University of Alabama at Birmingham, Birmingham, AL, ²Weill Cornell Medical College, New York City, NY
*Purpose: While the 2014 Kidney Allocation System (KAS) reduced deceased donor kidney transplant (DDKT) racial disparities, candidates’ community-level vulnerability has not been considered. The purpose…
2022 American Transplant Congress
A Prospective Randomised, Controlled Trial Switching Sirolimus For Mycophenolate To Enhance Immunological Responses To Third Dose Covid-19 Vaccination In Kidney Transplant Recipients With Poor Baseline Humoral Immunity
M. J. Tunbridge¹, G. Perkins², T. Salehi¹, B. Grubor-Bauk³, B. Sim¹, T. Ying⁴, J. J. Singer⁵, S. C. Barry⁶, P. Hissaria⁷, S. Chadban⁸, P. T. Coates¹
¹Central and Northern Adelaide Renal and Transplant Services, Royal Adelaide Hospital, Adelaide, Australia, ²School of Biological Sciences, University of Adelaide, Adelaide, Australia, ³Basil Hetzel Institute, University of Adelaide, Adelaide, Australia, ⁴University of Sydney, Lilyfield, Ne, Australia, ⁵Kidney Node Laboratory, Charles Perkins Centre, The University of Sydney, The University of Sydney, Australia, ⁶School of Medical Sciences, University of Adelaide, Adelaide, Australia, ⁷Department of Immunology, Royal Adelaide Hospital, Adelaide, Australia, ⁸Department of Nephrology, Royal Prince Alfred Hospital, Sydney, Australia
*Purpose: Kidney transplant recipients (KTR) have inadequate responses to 2-dose COVID vaccination schedules and are at increased risk of severe COVID-19. Formation of T cell…
2022 American Transplant Congress
Trends in Donor Derived Cell Free DNA Before and After Cellular and Antibody Mediated Rejection
K. Guo¹, J. Friedewald¹, C. Rebello¹, B. Kinsella¹, S. Park², L. Zhao¹
¹Northwestern University, Chicago, IL, ²Transplant nephrology, Northwestern University, Chicago, IL
*Purpose: The TRAC dd-cfDNA test was developed to detect acute kidney transplant rejection but can also detect subclinical rejection with improved performance in antibody-mediated rejection…
2022 American Transplant Congress
Month 1 Donor Derived Cell Free DNA Levels Predict Future Kidney Transplant Rejection
B. M. Kinsella¹, K. Guo¹, C. Rebello¹, L. Zhao¹, S. Park², J. Friedewald¹
¹Northwestern University, Chicago, IL, ²Transplant Nephrology, Northwestern University, Chicago, IL
*Purpose: The purpose of this study was to determine if donor-derived cell-free DNA (dd-cfDNA) can be used one-month post-transplant to predict later allograft rejection.*Methods: Retrospective…
2022 American Transplant Congress
Long-Term Kidney Allotransplant Acceptance is Defined by a Shift from a T Cell to a B Cell Rich Immune Microenvironment Within the Graft
E. S. Szuter¹, T. Yokose¹, M. T. Guinn¹, J. Ge², I. Rosales³, B. Kwon⁴, P. S. Russell¹, A. Cuenca², D. Kreisel⁵, P. Sage⁶, J. C. Madsen¹, R. B. Colvin³, A. Alessandrini¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Department of Surgery, Boston Children's Hospital, Boston, MA, ³Department of Pathology, Massachusetts General Hospital, Boston, MA, ⁴Harvard College, Cambridge, MA, ⁵Department of Surgery, Washington University, St. Louis, MO, ⁶Transplantation Research Center, Renal Division, Brigham and Women’s Hospital, Boston, MA
*Purpose: Mouse kidney allografts are spontaneously accepted in select, fully-mismatched donor-recipient strain combinations, such as DBA/2J to C57BL/6 (B6). Tolerant renal grafts develop aggregates of…
2022 American Transplant Congress
The Role of Donor Sex in Females Undergoing Repeat Kidney Transplant: Does Prior Donor Sex Matter?
S. Craig¹, K. Tennankore², A. J. Vinson²
¹Dalhousie University, Halifax, NS, Canada, ²Nova Scotia Health Authority, Halifax, NS, Canada
*Purpose: Female recipients of male donor kidneys are at increased risk for graft failure compared with all other donor-recipient sex pairings. The presumed mechanism relates…
2022 American Transplant Congress
Timing of Hypotension Post Kidney Transplant Impacts the Risk of Subsequent Delayed Graft Function
S. A. Morrison¹, A. Thanamayooran², K. Tennankore¹, A. J. Vinson¹
¹Dalhousie University, Halifax, NS, Canada, ²Nova Scotia Health Authority, Halifax, NS, Canada
*Purpose: Hypotension is common post-kidney transplant and is associated with delayed graft function (DGF; a need for dialysis in the first week post-transplant) and prolonged…
2022 American Transplant Congress
De Novo DSA in the Setting of Stable Allograft Function is a Benign Finding
R. J. Knight, E. A. Graviss, D. T. Nguyen, T. N. Eagar, S. G. Yi, H. Podder, M. Hobeika, R. McMillan, A. O. Gaber
Houston Methodist Hospital, Houston, TX
*Purpose: We sought to determine the long-term outcome of renal allografts that developed de novo DSA (dnDSA) in the setting of stable renal function.*Methods: A…
2022 American Transplant Congress
De Novo Focal Segmental Glomerulosclerosis in the Kidney Allograft: Association with Alloimmunity Leading to Poor Outcome
J. Leon¹, J. Duong Van Huyen², A. Abderrahmane¹, D. Anglicheau¹, C. Legendre¹, M. Rabant²
¹KIDNEY TRANSPLANTATION, Necker Hospital, Paris, France, ²KIDNEY PATHOLOGY, Necker Hospital, Paris, France
*Purpose: Focal Segmental Glomerulosclerosis (FSGS) can be found de novo (Dn) or as a recurrence in kidney allograft. While FSGS recurrence has been extensively described…