Am J Transplant, Volume 22, Suppl 3 Archives - Page 45 of 190 - ATC Abstracts

2022 American Transplant Congress
Off-the-Shelf Allogeneic Invariant NKT Cells Are Safe in the Dog and Induce Both Killer and Regulatory Immune Cells
A. Rotolo, E. Whelan, M. Atherton, K. Coker, R. Duran-Struuck, N. Mason
University of Pennsylvania Veterinary School of Medicine, Philadelphia, PA
*Purpose: Allogeneic invariant Natural Killer T cells (allo-iNKT) are attractive for transplant as they prevent graft rejection and maintain anti-tumor/pathogen effects but do not induce…
2022 American Transplant Congress
Immunomodulation in Lung Transplant May Facilitate Transformation of Usual Interstitial Pneumonia Into Pleuroparenchymal Fibroelastosis
Q. Cai¹, K. Batra², J. R. Torrealba¹
¹Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, TX, ²Department of Radiology, The University of Texas Southwestern Medical Center, Dallas, TX
*Purpose: Pleuroparenchymal fibroelastosis (PPFE) is a rare but distinctive manifestation of interstitial lung disease (ILD) characterized by a highly elastotic pattern of lung fibrosis. Its…
2022 American Transplant Congress
Utility of Bronchoalveolar Lavage Cytology for Detection of Malignancy or Infection in Lung Transplant Recipients
G. Cerro Chiang¹, R. Rampolla²
¹Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA, ²Department o Medicine, Cedars Sinai Medical Center, Los Angeles, CA
*Purpose: The role of cytologic evaluation in the diagnosis of acute allograft dysfunction has been described. Specific changes in cell count of bronchoalveolar lavage during…
2022 American Transplant Congress
Deep-Learning Based Pathological Assessment of Frozen Procurement Kidney Biopsies
Z. Yi¹, C. Xi¹, M. Menon², P. Cravedi¹, B. Murphy¹, S. Ward¹, F. Salem¹, W. Zhang¹
¹Icahn School of Medicine at Mount Sinai, New York, NY, ²Yale University School of Medicine, New York, NY
*Purpose: Organ shortage in kidney transplantation is a major issue for ESKD individuals on the waiting list. Sclerotic glomeruli or interstitial fibrosis on procurement donor…
2022 American Transplant Congress
Comprehensive Profiling of Monocytes During Cellular (TCMR) or Mixed Antibody-Mediated Rejection (ABMR) After Kidney Transplantation
C. Macedo¹, E. Bailly¹, K. Louis², X. Gu¹, M. Lucas¹, A. Zeevi¹, P. Randhawa¹, A. Bansal³, D. Metes¹
¹Starzl Transplantation Institute, Pittsburgh, PA, ²INSERM UMR-S976, Paris, France, ³University of Pittsburgh, Pittsburgh, PA
*Purpose: Monocytes play an important role in the immune defense by initiating adaptive immunity. They are heterogeneous, plastic, and present different subsets: classical (CD14++CD16-), intermediate…
2022 American Transplant Congress
Meld Score <31 Predicts Spontaneous Recovery in Patients Listed for Liver Transplantation for Alcohol-Associated Hepatitis: A UNOS Database Study
Y. Bekki, G. Im, T. Schiano, S. Florman
Icahn School of Medicine at Mount Sinai, RMTI, New York, NY
*Purpose: Alcohol-associated hepatitis (AH) is the fastest growing indication for liver transplantation (LT) in the U.S. While spontaneous recovery (SR) can occur in patients with…
2022 American Transplant Congress
Controlling Instability at Reperfusion: Another Benefit of Normothermic Machine Perfusion Using OCS Liver
C. S. Hwang¹, C. Shi², M. Patel¹, J. Shah¹, L. DeGregorio¹, S. Hanish¹, Y. Kadakia³, U. Chaudhary³, E. Okoro², S. Cheruku², P. Lahsaei², P. Vagefi¹, M. MacConmara⁴
¹Surgery, University of Texas Southwestern Medical Center, Dallas, TX, ²Anesthesia, University of Texas Southwestern Medical Center, Dallas, TX, ³University of Texas Southwestern Medical Center, Dallas, TX, ⁴TransMedics, Andover, MA
*Purpose: Organ Care System (OCS) Liver is a portable ex-vivo normothermic liver perfusion device recently shown to provide superior donor organ preservation. The impact of…
2022 American Transplant Congress
Vascularized Tracheal Transplantation; A One Year Update
E. M. Genden
Otolaryngology- Head and Neck Surgery, The Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: In January 2021, we performed the first single stage vascularized tracheal transplantation for reconstruction of a 9.5 cm tracheal airway defect. One year after…
2022 American Transplant Congress
Single Cell Multiomics Reveals Immune Mediators in Acute Cellular Rejection Following Pediatric Liver Transplantation
B. Rocque¹, D. Sarode², A. Barbetta³, P. Singh⁴, C. Goldbeck⁴, C. Weaver⁵, O. Akbari⁴, R. Kohli⁵, J. Emamaullee⁶
¹University of Southern California Keck School of Medicine, Los Angeles, CA, ²Keck School of Medicine of University of Southern California, Pasadena, CA, ³Surgery, abdominal transplat, University of Southern California, Los Angeles, CA, ⁴Keck School of Medicine of USC, Los Angeles, CA, ⁵Childrens Hospital Los Angeles, Los Angeles, CA, ⁶University of Southern California, Los Angeles, CA
*Purpose: Acute cellular rejection (ACR) is a common complication following pediatric liver transplantation with potential negative effects on allograft longevity. Currently, diagnosis and management are…
2022 American Transplant Congress
Absence of DAP12 Expression by Donor Liver-Derived Dendritic Cells Enhances Their Contact with T Cells in Host Secondary Lymphoid Tissue: Implications for Abrogation of MHC-mismatched Liver Transplant Tolerance in Mice
R. Nakano, A. Perez Gutierrez, G. Camirand, D. A. Geller, A. W. Thomson
University of Pittsburgh, Pittsburgh, PA
*Purpose: Multiphoton intravital microscopy is a high-resolution, real-time, fluorescence imaging technique that enables study of interactions between cells in their native, 3-dimensional environment including organ…