Am J Transplant, Volume 22, Suppl 3 Archives - Page 44 of 190 - ATC Abstracts

2022 American Transplant Congress
Semaglutide Tolerability and Efficacy in Patients with Chronic Kidney Disease Stage 4, 5 and End Stage Renal Disease
J. J. Long, A. Lemke, V. Sudhindran, N. Pencovici, A. Kukla, T. Diwan
Mayo Clinic, Rochester, MN
*Purpose: Obesity is often a barrier to kidney transplantation (KT) due to increased perioperative risks and worse outcomes with many transplant centers setting BMI cut…
2022 American Transplant Congress
Targeted Delivery of Costimulation Inhibitor to Lymph Nodes Promotes Transplant Tolerance via Fibroblastic Reticular Cells
J. Zhao¹, S. Jung¹, X. Li¹, H. Zhang¹, S. Movahedi¹, V. Kasinath¹, M. Uehara¹, J. Azzi¹, P. Sage¹, S. Tullius¹, J. S. Bromberg², R. Abdi¹
¹Brigham and Women's Hospital, Boston, MA, ²University of Maryland School of Medicine, Baltimore, MD
*Purpose: The lymph node (LN) is the primary site of alloimmunity activation and regulation during transplantation. Fibroblastic reticular cells (FRCs), the prominent cells of the…
2022 American Transplant Congress
“ABO-Adjusted CPRA”: A Unified Metric for Immunologic Compatibility in Kidney Transplantation
L. Gragert¹, M. Kadatz², J. Alcorn³, D. Stewart³, D. Chang², J. Gill², R. Liwski⁴, H. Gebel⁵, E. Kransdorf⁶, J. Gill², J. Lan²
¹Tulane University, New Orleans, LA, ²University of British Columbia, Vancouver, BC, Canada, ³UNOS, Richmond, VA, ⁴Dalhousie University, Halifax, NS, Canada, ⁵Emory University, Atlanta, GA, ⁶Cedars-Sinai, Beverly Hills, CA
*Purpose: Implementation of the kidney allocation system in 2014 greatly reduced access disparity due to HLA sensitization. To address persistent disparities among both candidate cPRA…
2022 American Transplant Congress
Cardiovascular Assessment After Kidney Transplantation in Children and Adolescents
J. Liu, L. Zhang, X. Li, L. Zhu, Y. Lin, X. He, L. Liu, J. Li, C. Wang, S. Li
The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
*Purpose: End-stage renal disease is often accompanied by cardiovascular events, and cardiovascular events still exist after kidney transplantation. Cardiovascular disease is the main cause of…
2022 American Transplant Congress
Lung Transplant Recipients with Sars-cov2 Infection and Bnt162b2 Vaccination Induce Circulating Exosomes with Spike Protein S2 Capable of Inducing Immune Responses to Sars0-cov2 in Mice
S. Bansal¹, B. Tiffany¹, T. Fleming¹, S. Perincheri², M. Smith¹, R. Bremner¹, T. Mohanakumar¹
¹St. Joseph’s Hospital and Medical Center, Phoenix, AZ, ²Yale School of Medicine, New Haven, CT
*Purpose: Exosomes are small vesicles which are released by cells into body fluids. We have demonstrated the presence of circulating exosomes with viral antigens in…
2022 American Transplant Congress
Clinical Outcomes of Solid Organ Transplant (SOT) Patients with Epstein-Barr Virus-Driven (EBV⁺) Post-Transplant Lymphoproliferative Disease (PTLD) Who Fail Rituximab Plus Chemotherapy: A Multinational, Retrospective Chart Review Study
V. Dharnidharka¹, D. Thirumalai², U. Jaeger³, W. Zhao², D. Dierickx⁴, P. Xun², P. Minga⁵, A. Sawas⁶, N. Sadetsky⁷, P. Chauvet⁸, E. Sundaram⁹, A. Barlev⁷, H. Zimmermann¹⁰, R. U. Trappe¹⁰
¹Washington University School of Medicine/St Louis Children’s Hospital, St Louis, MO, ²Atara Biotherapeutics, Thousand Oaks, CA, ³Medical University of Vienna, Vienna, Austria, ⁴Universitair Ziekenhuis Leuven, Leuven, Belgium, ⁵Niguarda Ca’ Granda Hospital, Milan, Italy, ⁶Herbert Irving Comprehensive Cancer Center, Department of Medicine, CUMC, New York, NY, ⁷Atara Biotherapeutics, South San Francisco, CA, ⁸Service des Maladies du Sang, CHU Lille, Lille, France, ⁹Nashville Biosciences, Nashville, TN, ¹⁰DIAKO Bremen, Bremen, Germany
*Purpose: EBV+ PTLD patients (pts) following SOT who fail rituximab + chemotherapy (CT) have poor outcomes with limited treatment options. Published data on clinical outcomes…
2022 American Transplant Congress
Cognitive Bias in Transplant Surgery: A Qualitative Study of Transplant Clinicians in the United States
K. Ladin¹, J. Perry², C. Eiduson³
¹REACH Lab, Tufts University, Medford, MA, ²Harvard University, Cambridge, MA, ³University of Rochester School of Medicine & Dentistry, Rochester, NY
*Purpose: Clinicians’ judgments about patients’ social support often affect whether patients are listed for transplantation. Decision-making is thought to be based on two systems of…
2022 American Transplant Congress
Bcl6 Regulates NFκB-Controlled Endothelial Inflammation and Apoptosis
A. Franco Acevedo, N. Valenzuela
Pathology and Laboratory Medicine, UCLA, Los Angeles, CA
*Purpose: Endothelial cells (EC) centrally regulate leukocyte access to peripheral tissue and immune cell activation, and exhibit remarkable tissue-specific diversity. However, the molecular mechanisms underlying…
2022 American Transplant Congress
Evaluation of Diabetes-Free Life Expectancy Among Living Kidney Donors and Non-Donors with Obesity: A Longitudinal Cohort Study
C. Killian¹, R. Reed¹, M. McLeod¹, P. MacLennan¹, V. Kumar¹, S. Brooks¹, A. Maynor¹, L. Stanford¹, G. Baker¹, C. Schinstock², J. Silkensen³, G. Roll⁴, D. Segev⁵, B. Orandi¹, C. Lewis¹, J. Locke¹
¹University of Alabama at Birmingham, Birmingham, AL, ²Mayo Clinic, Rochester, MN, ³Hennepin County Medical Center, Minneapolis, MN, ⁴UCSF Medical Center, San Francisco, CA, ⁵Johns Hopkins University, Baltimore, MD
*Purpose: The growing end stage kidney disease burden paired with substantial rates of obesity in the United States (US) has prompted increased approval of obese…
2022 American Transplant Congress
Single Cell RNA Sequencing Identifies Primarily Terminal Effector and Exhausted CD8⁺T Cells in Chronically Rejected Human Kidney Allografts
S. G. Yi¹, D. Zou¹, Y. Dai², Z. Zhao², W. Chen¹, A. Gaber¹
¹Department of Surgery, Houston Methodist Hospital, Houston, TX, ²School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX
*Purpose: Chronic renal allograft rejection often leads to irreversible damage, despite intensification of immunosuppression (ISN). T cell phenotypes in this clinical setting are not well…