Am J Transplant, Volume 22, Suppl 3 Archives - Page 44 of 190 - ATC Abstracts

2022 American Transplant Congress
Role of CD8⁺T Cells Exhaustion in Long Term Spontaneous Acceptance of Mouse Kidney Allograft
J. Ge¹, E. Szuter¹, T. Yokose¹, I. Rosales², A. Cuenca³, P. Russell¹, J. Madsen¹, R. Colvin², A. Alessandrini¹
¹Center of Transplant Science, Massachusetts General Hospital, Boston, MA, ²Department of Pathology, Massachusetts General Hospital, Boston, MA, ³Department of Surgery, Boston Children's Hospital, Boston, MA
*Purpose: CD8+ T cells exhaustion has been shown to promote chronic viral infection and tumor development, resulting from long term exposure to foreign antigen. We…
2022 American Transplant Congress
Fcγ Receptor-Positive Cells Play a Critical Role in Rejection of Allogeneic Bone Marrow Cells Mediated by Anti-Donor Antibodies
H. Xu¹, Y. Huang¹, H. Xu²
¹Talaris, Louisville, KY, ²Talaris Therapeutics, Louisville, KY
*Purpose: Sensitization through prior exposure to MHC antigens results in an increased rate of graft rejection. We previously reported that humoral immunity is the primary…
2022 American Transplant Congress
Assessment of Letermovir as Universal Prophylaxis for Cytomegalovirus Infection in Lung Transplant Recipients
L. F. Borges, T. Sparkman, K. Gutierrez, J. Banbury
UAB Hospital, Birmingham, AL
*Purpose: Cytomegalovirus (CMV) poses a significant concern in the post-operative management of lung transplant (LT) recipients. Current recommended prophylactic strategies with ganciclovir (GCV) or valganciclovir…
2022 American Transplant Congress
A Population-Based Analysis of Long-Term Outcomes Following Pediatric Acute Liver Failure Highlights High Risk Populations in Access to Transplant
J. Ascher Bartlett¹, M. Lo², K. Etesami³, L. Sher³, R. Kohli¹, J. Emamaullee³
¹Gastroenterology, Hepatology and Nutrition, Children's Hospital Los Angeles, Los Angeles, CA, ²University of Southern California, Los Angeles, CA, ³Surgery, Keck Medicine of University of Southern California, Los Angeles, CA
*Purpose: Pediatric acute liver failure (PALF) is a potentially devastating illness that affects otherwise healthy children. Nearly 70% of children with PALF will recover, while…
2022 American Transplant Congress
Marginal Zone Phenotype B Cells Are Required for Formation of Donor-Specific IgG After Allogeneic Sensitization
M. A. Kallarakal, G. Cohen, S. M. Krummey
Department of Pathology, Johns Hopkins University, Baltimore, MD
*Purpose: The formation of allogeneic antibody directed against non-self MHC, termed donor-specific antibody (DSA), is a significant barrier to successful transplant outcomes. Pre-formed DSA limits…
2022 American Transplant Congress
Regulatory T Cells Suppress Memory IL-17a Production in Highly Sensitised Patients with End-Stage Renal Disease
C. Dudreuilh¹, S. Basu¹, O. Shaw², H. Burton¹, C. Domingo-Vila¹, T. Tree¹, G. Lombardi¹, C. Scotta¹, A. Dorling¹
¹King's College London, London, United Kingdom, ²Viapath Clinical Transplantation Laboratory, Guy's Hospital, London, United Kingdom
*Purpose: Highly sensitised patients exhibit poorer long-term outcomes following renal transplantation compared to those non sensitised individuals. IL17-A has been associated with acute rejection. Presence…
2022 American Transplant Congress
Center-Level Variation in Transplantation Practice Following Acuity Circles Policy Change
A. Burton¹, D. Goldberg²
¹University of Miami Miller School of Medicine, Miami, FL, ²Department of Gastroenterology, University of Miami Miller School of Medicine, Miami, FL
*Purpose: Although early studies suggest that the Acuity Circles (AC) allocation policy has reduced disparities in access to deceased donor liver transplants (DDLTs), changes in…
2022 American Transplant Congress
Natural Antibodies Are Associated With Rejection And Long-term Renal Allograft Loss In A Multi-center International Cohort
S. B. See¹, X. Yang², C. Burger³, B. Lamarthée⁴, R. Snanoudj⁵, R. Shihab¹, D. S. Tsapepas⁶, P. Roy¹, S. Larivière-Beaudoin⁷, K. Hamelin⁷, A. Mendoza Rojas⁸, N. M. van Besouw⁸, A. Bartosic⁹, N. Daniel⁹, E. R. Vasilescu¹⁰, S. Mohan¹¹, D. Cohen¹¹, L. Ratner¹¹, C. C. Baan⁸, J. S. Bromberg⁹, H. Cardinal⁷, D. Anglicheau³, Y. Sun², E. Zorn¹
¹CCTI, Columbia University Irving Medical Center, New York, NY, ²Biostatistics, Columbia University Irving Medical Center, New York, NY, ³Necker Hospital, Paris, France, ⁴Necker-Enfants Malades Institute, Paris, France, ⁵Bicêtre Hospital, Paris, France, ⁶Surgery, Columbia University Irving Medical Center, New York, NY, ⁷CHUM, Montreal, QC, Canada, ⁸Erasmus MC, Rotterdam, Netherlands, ⁹Surgery, University of Maryland School of Medicine, Baltimore, MD, ¹⁰Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, ¹¹Medicine, Columbia University Irving Medical Center, New York, NY
*Purpose: Potentially harmful non-donor-specific human leukocyte antigen antibodies have been identified in renal transplantation, including natural IgG antibodies (Nabs) reactive to varied antigenic structures.*Methods: In…
2022 American Transplant Congress
Impact of Immunosuppressive Medications on SARS-CoV-2 Vaccination Response in Kidney Transplant Patients
O. Sogbein¹, A. Rizvi², M. Mujtaba³, M. Kueht⁴, J. Fair⁴, A. Gamilla-Crudo³, S. Hussain⁵
¹Internal Medicine, Division of Nephrology, University of Texas Medical Branch, Galveston, TX, ²Internal Medicine, Nephrology, University of Texas Medical Branch at Galveston, Galveston, TX, ³University of Texas Medical Branch, Galveston, TX, ⁴Surgery, University of Texas Medical Branch, Galveston, TX, ⁵University of Texas Medical Branch, Houston, TX
*Purpose: The COVID-19 pandemic portends significant morbidity and mortality in immunocompromised individuals. Vaccination against COVID-19 among immunocompromised population is an essential step to minimize deadly…
2022 American Transplant Congress
Collaboration for Successful Transition to Adult Care in Liver Transplant: Early Outcomes of a Structured Program with Youth Engagement
B. Kosmach-Park¹, J. Kilpatrick², A. Algeo¹, K. Jones¹, L. Remaley¹, N. Elazzazy², N. Jonassaint³, G. Mazariegos¹
¹Transplant Surgery, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, ²Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, ³Department of Medicine and Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA
*Purpose: To effectively transition youth to adult hepatology through a structured program and developed partnerships while promoting and maintaining optimal outcomes.*Methods: The pediatric and adult…