Am J Transplant, Volume 22, Suppl 3 Archives - Page 42 of 190 - ATC Abstracts

2022 American Transplant Congress
Tacrolimus Induces Dedifferentiation of Pancreatic Beta Cells by Inhibition of Calcineurin/NFATc2 and Islet Cell Differentiation Genes
C. M. Darden¹, S. Vasu², J. Mattke³, Y. Liu², B. Naziruddin⁴, M. C. Lawrence²
¹Baylor University, Dallas, TX, ²Baylor University Medical Center, Dallas, TX, ³Baylor University, Waco, TX, ⁴Baylor University Medical Ctr, Dallas, TX
*Purpose: Tacrolimus (FK506) is a potent immunosuppressant widely used for solid organ transplantation to prevent lymphokine gene expression by inhibiting calcineurin (CN) and its downstream…
2022 American Transplant Congress
The Role of LAG3 in Antibody Responses to Kidney Transplantation
M. Nicosia¹, R. Fan¹, J. Lee², V. Gorbacheva¹, A. M. Beavers¹, N. Dvorina¹, W. Baldwin III¹, R. L. Fairchild¹, B. Min³, A. Valujskikh¹
¹Inflammation and Immunity, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, ²Cardiovascular and Metabolic Science, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, ³Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL
*Purpose: The functions of coinhibitory receptor lymphocyte activation gene-3 (LAG3) in T cells are well studied, however its role in humoral immune responses remains poorly…
2022 American Transplant Congress
TCMR in Late Kidney Transplant Biopsies Shows Less Molecular TCMR Activity and More Fibrosis Despite Persistence of Tubulitis and Interstitial Infiltrate
K. S. Madill-Thomsen¹, J. Reeve¹, P. Halloran¹, .. and the INTERCOMEX Study Group²
¹Alberta Transplant Applied Genomics Centre, Edmonton AB, AB, Canada, ²., ., AB, Canada
*Purpose: We studied the relationship between time post-transplant and molecular T cell-mediated rejection (TCMR) activity in a population of indication kidney transplant biopsies.*Methods: Updated rejection-based…
2022 American Transplant Congress
Factor V Leiden Heterozygosity and Live Donor Liver Donation – A Single Center Analysis
D. Reddy, S. Ganesh, A. M. Thompson, V. Gunabushanam, A. Ganoza, M. Molinari, A. Tevar, C. Hughes, A. Humar
Thomas E Starzl Transplant Institute, University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: Living donor liver transplantation (LDLT) accounts for only a small percentage (< 6%) of all liver transplants performed for adult recipients in the western…
2022 American Transplant Congress
Organ Transplant Outcomes from Donors with Positive SARS-CoV-2 PCRs in New York: A Case Series
A. L. Friedman¹, M. Pereira², M. Rana³, J. Akpede⁴, A. Dhand⁵
¹LiveOnNY, New York, NY, ²New York Presbyterian Hospital, New York, NY, ³Icahn School of Medicine at Mount Sinai, New York, NY, ⁴LiveOnNY, Long Island City, NY, ⁵Westchester Medical Center, Chappaqua, NY
*Purpose: Rapid evolution of the SARS-CoV-2 pandemic over the past 24 months has demanded agility in managing selection criteria for deceased organ donors, with the…
2022 American Transplant Congress
Survey of Current Transplant Center Practices Regarding Covid-19 Vaccine Mandates in the United States
B. E. Hippen¹, D. Axelrod², K. Maher³, R. Xi³, D. Kumar⁴, M. Schnitzler³, K. Lentine³
¹Head of Transplant Medicine, Fresenius Medical Care, Charlotte, NC, ²University of Iowa Transplant Clinic, Iowa City, IA, ³St. Louis University School of Medicine, St. Louis, MO, ⁴Ajmera Transplant Centre, Toronto, ON, Canada
*Purpose: We surveyed current policies of transplant centers regarding a COVID-19 vaccine mandate, and rationales for or against a mandate policy.*Methods: An electronic survey was…
2022 American Transplant Congress
Disulfide HMGB1 Reprograms Macrophages to Induce Alloimmunity via TLR4 and TLR9 Pathways Following Ischemia-Reperfusion Injury in Human Orthotopic Liver Transplantation
A. Q. Terry¹, R. A. Sosa¹, F. Kaldas², R. Busuttil³, D. Gjertson¹, J. Kupiec-Weglinski¹, E. Reed¹
¹Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, ²University of California Los Angeles (Multi-organ), Los Angeles, CA, ³Surgery, University of California, Los Angeles, Los Angeles, CA
*Purpose: Human hepatocellular damage caused by ischemia reperfusion injury (IRI) generates the disulfide form of HMGB1 (diS HMGB1), eliciting myeloid cell activation and proinflammatory cytokine…
2022 American Transplant Congress
Binding Mechanisms For Donor Dc-derived Exosomes To Cross-dress Of Recipient Dc
L. ZHANG¹, X. LI¹, J. LIU¹, H. WEI¹, C. LI¹, A. HUANG², C. ZHENG¹, Q. LIU¹
¹Department of Biochemistry, Southern University of Science and Technology, Shenzhen, China, ²Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
*Purpose: Our previous evidence suggests donor dendritic cell (DC)-derived exosomes cross-dress recipient DC after heart transplantation in mice. This process plays a critical role in…
2022 American Transplant Congress
Dynamic Risk Prediction of Kidney Graft Failure After Deceased Donor Transplant
D. G. Hu¹, H. Thiessen Philbrook¹, S. Mohan², I. Hall³, M. Doshi⁴, K. F. Kerr⁵, C. R. Parikh¹
¹Johns Hopkins University, Baltimore, MD, ²Columbia University Medical Center, New York, NY, ³University of Utah, Salt Lake City, UT, ⁴University of Michigan, Ann Arbor, MI, ⁵University of Washington, Seattle, WA
*Purpose: Identifying kidney transplant recipients at risk of graft failure allows for early intervention in clinical care. We developed a dynamic risk prediction model based…
2022 American Transplant Congress
18 Month Review of Liver Acuity Circles Allocation
J. Foutz¹, S. Noreen¹, M. Cafarella¹, A. Wilk¹, J. Trotter², S. Biggins³, J. Pomposelli⁴
¹United Network for Organ Sharing, Richmond, VA, ²Baylor University Medical Center, Dallas, TX, ³University of Washington, Seattle, WA, ⁴University of Colorado, Aurora, CO
*Purpose: Acuity circles (AC) allocation was implemented on 2/4/2020 with a goal of removing DSA and region from liver allocation and broadening the distribution of…