ATC Abstracts

American Transplant Congress abstracts

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  • 2022 American Transplant Congress

    Longitudinal Characterization of Memory B Cells During Antibody Mediated Rejection Treated with Plasmapheresis, Bortezomib, and Belatacept in Heart Transplant Recipients

    F. Alkhunaizi1, M. Ellison2, V. Berrich1, M. Siegelin1, M. Szabolcs1, G. F. Sayer1, N. Uriel1, S. Restaino1, A. Chong3, A. Zeevi2, M. Habal1

    1Columbia University Medical Center, New York, NY, 2University of Pittsburgh Medical Center, Pittsburgh, PA, 3University of Chicago, Chicago, IL

    *Purpose: Donor specific antibodies (DSA) and antibody mediated rejection (AMR) continue to limit allograft longevity after heart transplant. Effective treatments are limited and often complicated…
  • 2022 American Transplant Congress

    Kinetic Analysis of Post-Clearance Phase Inflammation in Kidney Biopsies After BK Viremia

    M. Vincent1, J. T. Rajagopal1, E. Farkash2

    1University of Michigan, Ann Arbor, MI, 2Dept. of Pathology, University of Michigan, Ann Arbor, MI

    *Purpose: During the post-clearance phase of BK polyomavirus nephropathy, tubulointerstitial inflammation can persist despite resolution of BK viremia. This inflammation is indistinguishable from low grade…
  • 2022 American Transplant Congress

    Abnormal Kidney T Cell Metabolism During Ischemia Reperfusion Injury Can Be Modified to Improve Organ Structure and Function

    K. Lee, E. A. Thompson, C. H. Patel, S. Gharaie, J. T. Kurzhagen, S. Noel, P. M. Pierorazio, B. S. Slusher, H. Rabb

    Johns Hopkins University School of Medicine, Baltimore, MD

    *Purpose: T cells play an important role in the pathophysiology of kidney ischemia reperfusion injury (IRI). Metabolic programming of T cells, a rapidly evolving field,…
  • 2022 American Transplant Congress

    Understanding The Modification Of Eplet Mismatch Risk By Immunosuppression Regimen

    A. Johnson1, X. Zhang1, L. Gragert2, C. Larsen1

    1Emory University School of Medicine, Atlanta, GA, 2Tulane University School of Medicine, New Orleans, LA

    *Purpose: Solid organ transplant donor-recipient eplet mismatch has been correlated with subsequent donor specific antibody (DSA) formation, antibody mediated rejection, and overall rejection rates. However,…
  • 2022 American Transplant Congress

    Addressing the Organ Shortage, Improving Transplant Longevity, and Enabling Minimally Invasive Kidney Transplantation: Development of an Intraoperative Kidney Anastomosis Facilitation and Regelation Device

    K. S. Hansen1, R. Meier2, J. Gardner1

    1University of California San Francisco, San Francisco, CA, 2Division of Transplant Surgery, University of Maryland, San Francisco, CA

    *Purpose: Second warm ischemia time (SWIT) of a renal allograft during anastomosis increases rates of delayed graft function and premature graft failure. In the setting…
  • 2022 American Transplant Congress

    Four Separate Frailty Metrics Lack Concordance and Are Non-Reflective of the Kidney Transplant Listing Outcome: A Large Single Center Review

    A. Cimeno, G. Lewis, R. Parsons

    Transplant Surgery, Emory University Hospital, Atlanta, GA

    *Purpose: It is well known that functional status has prognostic value for post-surgical outcomes, however pre-transplant patients are not required to undergo objective frailty testing.…
  • 2022 American Transplant Congress

    Safety and Immunogenicity of Live Viral Vaccination After Pediatric Liver and Kidney Transplantation

    A. Feldman1, B. Beaty1, N. Ebel2, J. Ferrolino3, V. Gopalareddy4, J. Hollenbeck5, C. Jaramillo6, N. Kerkar7, S. Lerret8, G. Maron3, A. Mavis9, N. Ovchinsky10, M. Sell11, T. Sharma12, J. Stoll13, L. Danziger-Isakov14

    1UCD, Aurora, CO, 2Stanford, Palo Alto, CA, 3St. Jude, Memphis, TN, 4LCH, Charlotte, NC, 5Michigan Medicine, Ann Arbor, MI, 6PCH, Salt Lake City, UT, 7URMC, Rochester, NY, 8MCW, Milwaukee, WI, 9Duke, Durham, NC, 10Montefiore, NYC, NY, 11MUSC, Charleston, SC, 12BCH, Boston, MA, 13WUSM, St Louis, MO, 14CCHMC, Cincinnati, OH

    *Purpose: New recommendations suggest that measles-mumps-rubella vaccine (MMR-vx) and varicella vaccine (VZV-vx) may be administered to certain non-immune transplant recipients. The purpose of this study…
  • 2022 American Transplant Congress

    Adenovirus Enteritis Following Intestinal Transplantation

    S. Jafri1, A. Mavis2, J. Weiner3, M. C. Segovia2

    1Henry Ford Health System, Detroit, MI, 2Duke University, Durham, NC, 3Columbia, New York, NY

    *Purpose: Intestinal transplant is a life-saving therapy for intestinal failure. Adenovirus Enteritis (AE) is an unusual infection identified on biopsy or serology following intestine or…
  • 2022 American Transplant Congress

    Local Mesenchymal Stem Cell Therapy for the Ex Vivo Preservation of a Porcine Vascularized Composite Allograft with 24-hour Normothermic Machine Perfusion

    A. Bernal1, J. Hinshaw1, J. Pena1, C. Hinshaw1, D. Wood1, K. Zimmern2, N. McMahon2, J. Ling2, W. Zhang1, E. Weitzel1

    1US Army Institute of Surgical Research/59th MDW, San Antonio, TX, 2Southwest Research Institute, San Antonio, TX

    *Purpose: Given therapeutic limitations in limb salvage, we sought to demonstrate the efficacy of combining local mesenchymal stem cells (MSCs) infusion with fresh whole blood…
  • 2022 American Transplant Congress

    Deep Phenotyping Methods Highlight Recipient-Derived CD16+ NK and CD16+ Monocyte Infiltration During Kidney Transplant Rejection

    B. Lamarthée1, J. Callemeyn1, P. Koshy2, T. Debyser3, E. Van Loon1, A. Franken4, T. Van Brussel4, I. Arijs4, D. Lambrechts4, A. Senev1, T. Vaulet5, C. Tinel1, M. Naesens1

    1Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, 2Department of Morphology and Molecular Pathology, University Hospitals Leuven, Leuven, Belgium, 3Faculty of Medicine, KU Leuven, Leuven, Belgium, 4Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium, 5ESAT Stadius Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven, Belgium

    *Purpose: How the immune system participates to kidney transplant rejection has not been fully elucidated. Single-cell (sc) genomics techniques are revolutionizing our ability to characterize…
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