2022 American Transplant Congress
Immunosuppressants Alter Lymph Node Architecture and Create Distinct Microbiome Footprints
1University of Maryland School of Medicine, Baltimore, MD, 2University of Maryland, Baltimore, MD
*Purpose: There are complex interactions among immunosuppressants, antibiotics, and the gut microbiome on the host immune system. Microbiota can alter lymph node (LN) structure and…2022 American Transplant Congress
Single-Cell Multiomics Defines Tolerogenic Extrathymic Aire-Expressing Cells
*Purpose: The Autoimmune Regulator (Aire) gene, essential for central tolerance through its regulation of tissue-specific antigens in medullary thymic epithelial cells, is also expressed in…2022 American Transplant Congress
Portal Hypertension Inhibits the Antitumor Effect of Liver-Resident NK Cells Through IL-33 Signal
Hiroshima University, Hiroshima, Japan
*Purpose: Portal vein hypertension (PHT) after living donor liver transplantation (LDLT) is known to have associated with poor prognosis. Among patients with hepatocellular carcinoma (N=…2022 American Transplant Congress
Differences of Fk-Binding Protein 12 and P-Glycoprotein Explain the Differences in the Intracellular Tacrolimus Concentration of T Lymphocytes and Monocytes
Erasmus MC, Rotterdam, Netherlands
*Purpose: Little is known about the pharmacokinetics of intracellular tacrolimus, particularly in T lymphocytes and monocytes. We demonstrated a significantly lower intracellular tacrolimus concentration in…2022 American Transplant Congress
The Higher Cost of Donation After Circulatory Death Liver Transplantation Starts with Acquisition Costs: A Single Center Comparison Liver Acquisition Fees by Donor Type
*Purpose: Donation after circulatory death (DCD) donors are an increasing proportion of deceased donor population in the US. One drawback of DCD donors is that…2022 American Transplant Congress
Technical Report to Increased Utilization of Injured Kidneys: CT Scan to Evaluate Organ and Reduce Discard
Surgery, Columbia Vagelos College of Physicians and Surgeons, New York, NY
*Purpose: To reduce discard of injured kidneys with parenchymal injury or perinephric hematoma . Young donors with good function but injury are at high risk…2022 American Transplant Congress
Impact of Changing Tacrolimus Formulation on Cerebral Blood Flow and Cognitive Function
University of Kansas Medical Center (KUMC), Kansas City, KS
*Purpose: To assess if switching to extended release (ER) tacrolimus changes cerebral blood flow (CBF) or cognitive function after switching stable kidney transplant (KT) recipients…2022 American Transplant Congress
TNFRSF13B Genotype Determines the Properties of Donor-Specific B Cells
*Purpose: The TNFRSF13B gene is among the 5% most polymorphic genes in humans. The phenotypes of the most frequent TNFRSF13B variants in humans and mice…2022 American Transplant Congress
Donor Genetic Background Predisposes Differentiation and Accumulation of Regulatory T Cells in the Kidney Allografts
*Purpose: We have previously demonstrated that donor kidney-intrinsic innate immunity determines the severity of delayed graft function (DGF) in kidney transplantation and potentiates long kidney…2022 American Transplant Congress
Association of Chest CT Score During Acute COVID-19 Illness with Subsequent Lung Function Loss Among Lung Transplant Patients
University of Texas Southwestern, Dallas, TX
*Purpose: Limited data exists on CT chest abnormalities during acute Coronavirus disease 2019 (COVID-19) infection and associated post-illness loss of lung function among lung transplant…
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