Am J Transplant, Volume 22, Suppl 3 Archives - Page 37 of 190 - ATC Abstracts

2022 American Transplant Congress
Why is Adolescent Waitlist Mortality Higher for Status 1A Girls?
J. Foutz¹, E. Hsu², S. Noreen³, M. Cafarella⁴, J. Pomposelli⁵, S. Biggins⁶, J. Reyes⁶, E. Perito⁷
¹Research, United Network for Organ Sharing, Richmond, VA, ²Seattle Children's Hospital, Seattle, WA, ³United Network for Organ Sharing, Richmond, VA, ⁴Policy and Community Relations, United Network for Organ Sharing, Richmond, VA, ⁵University of Colorado, Aurora, CO, ⁶University of Washington, Seattle, WA, ⁷UCSF, San Francisco, CA
*Purpose: Although adolescent pediatric liver transplant candidates are a vulnerable population, they are often excluded from analyses due to small sample size and assignment of…
2022 American Transplant Congress
Tocilizumab in Chronic Active Antibody-Mediated Rejection in Kidney Transplant Recipients: A Case Series
B. Boonpheng¹, R. Bakthavatsalam², C. D. Blosser¹, I. C. De Castro¹, I. Gimferrer³, Y. Ng¹, N. Leca¹
¹Nephrology, University of Washington, Seattle, WA, ²Surgery, University of Washington, Seattle, WA, ³Bloodworks Northwest, Seattle, WA
*Purpose: The optimal treatment for chronic active antibody-mediated rejection (ca-AMR) remains unclear. Tocilizumab (TCZ), a monoclonal antibody against IL-6, has been proposed in ca-AMR treatment…
2022 American Transplant Congress
Treatment of BK Virus with Weekly Intravenous Immunoglobulin in Adult Kidney Transplant Recipients
G. Girone¹, W. Asch²
¹Department of Pharmacy, Yale New Haven Hospital, New Haven, CT, ²Section of Nephrology, Yale School of Medicine, New Haven, CT
*Purpose: The typical management of Polyoma BK virus (BKV) in kidney transplant recipients (KTR) includes reducing immunosuppression (IS). Intravenous immunoglobulin (IVIG) has been utilized for…
2022 American Transplant Congress
Removing DSA and Region from Organ Allocation
R. R. Goff¹, A. R. Wilk¹, J. Foutz¹, A. Robinson¹, S. E. Booker¹, K. Bradbrook¹, T. Mupfudze¹, N. Turgeon², M. Cooper³, D. Klassen¹
¹United Network for Organ Sharing, Richmond, VA, ²University of Texas at Austin, Austin, TX, ³Medstar Georgetown, Washington , D.C., DC
*Purpose: Over the past 4 years, the OPTN has removed Donation Service Area (DSA) and OPTN Region from deceased donor organ allocation with the goal…
2022 American Transplant Congress
Immunosuppressants Alter Lymph Node Architecture and Create Distinct Microbiome Footprints
S. J. Gavzy¹, R. Lakhan², J. Iyyathurai², V. Saxena², L. Li², B. Ma², E. Mongodin², J. S. Bromberg²
¹University of Maryland School of Medicine, Baltimore, MD, ²University of Maryland, Baltimore, MD
*Purpose: There are complex interactions among immunosuppressants, antibiotics, and the gut microbiome on the host immune system. Microbiota can alter lymph node (LN) structure and…
2022 American Transplant Congress
Single-Cell Multiomics Defines Tolerogenic Extrathymic Aire-Expressing Cells
A. R. Gupta¹, J. Wang², C. Lareau³, I. Sun², J. Bautista¹, J. Gardner¹
¹Department of Surgery, University of California San Francisco, San Francisco, CA, ²Diabetes Center, University of California San Francisco, San Francisco, CA, ³Department of Pathology, Stanford University, Stanford, CA
*Purpose: The Autoimmune Regulator (Aire) gene, essential for central tolerance through its regulation of tissue-specific antigens in medullary thymic epithelial cells, is also expressed in…
2022 American Transplant Congress
Portal Hypertension Inhibits the Antitumor Effect of Liver-Resident NK Cells Through IL-33 Signal
Y. Imaoka, M. Ohira, K. Sato, K. Imaoka, R. Nakano, Y. Tanaka, H. Ohdan
Hiroshima University, Hiroshima, Japan
*Purpose: Portal vein hypertension (PHT) after living donor liver transplantation (LDLT) is known to have associated with poor prognosis. Among patients with hepatocellular carcinoma (N=…
2022 American Transplant Congress
Differences of Fk-Binding Protein 12 and P-Glycoprotein Explain the Differences in the Intracellular Tacrolimus Concentration of T Lymphocytes and Monocytes
S. Udomkarnjananun, C. Baan, B. de Winter, D. Hesselink
Erasmus MC, Rotterdam, Netherlands
*Purpose: Little is known about the pharmacokinetics of intracellular tacrolimus, particularly in T lymphocytes and monocytes. We demonstrated a significantly lower intracellular tacrolimus concentration in…
2022 American Transplant Congress
The Higher Cost of Donation After Circulatory Death Liver Transplantation Starts with Acquisition Costs: A Single Center Comparison Liver Acquisition Fees by Donor Type
V. Reddy¹, S. Asrani², J. Trotter², R. Ruiz³, S. Lee², E. Martinez², N. Onaca², G. McKenna⁴, A. Gupta², H. Fernandez², J. Bayer², G. Testa², A. Wall²
¹Baylor Scott and White Research Institute, Allen, TX, ²Baylor University Medical Center, Dallas, TX, ³Baylor University Medical Center, Fort Worth, TX, ⁴Baylor Simmons Transplant Inst, Dallas, TX
*Purpose: Donation after circulatory death (DCD) donors are an increasing proportion of deceased donor population in the US. One drawback of DCD donors is that…
2022 American Transplant Congress
Technical Report to Increased Utilization of Injured Kidneys: CT Scan to Evaluate Organ and Reduce Discard
V. E. Whittaker
Surgery, Columbia Vagelos College of Physicians and Surgeons, New York, NY
*Purpose: To reduce discard of injured kidneys with parenchymal injury or perinephric hematoma . Young donors with good function but injury are at high risk…