Am J Transplant, Volume 22, Suppl 3 Archives - Page 36 of 190 - ATC Abstracts

2022 American Transplant Congress
Natural vs Induced ABO Antibodies in a Murine Model: Role of Sex and T Cells
I. Adam¹, B. Motyka¹, K. Tao¹, P. J. Cowan², L. J. West¹
¹University of Alberta, Edmonton, AB, Canada, ²University of Melbourne, Melbourne, Australia
*Purpose: Interaction of ‘natural’ ABO antibodies (nAbs) with their cognate AB(H)-antigens (Ags) poses a high risk of rapid rejection of ABO-incompatible (ABOi) organ transplants. We…
2022 American Transplant Congress
Generation Of Insulin Producing Cells From Pancreatic Tissue With Long Standing Type 1 Diabetes
Y. Garciafigueroa, J. B. Pollett, N. L. Thai, R. Bottino
Imagine Pharma, Pittsburgh, PA
*Purpose: AIPCs (Activated Islet Proliferating Cells), are a novel cell population from isolated human islets obtained using a simple culture protocol that can generate cells…
2022 American Transplant Congress
Belatacept Conversion in Proteinuric Kidney Transplant Recipients: Effects in a Prospective Trial and a Retrospective Cohort
O. Efe¹, A. Al Jurdi¹, D. Wojciechowski², K. Safa¹, H. Gilligan¹, A. Chandraker³, J. Azzi³, A. Weins³, L. V. Riella¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Charlestown, MA, ²UT Southwestern Medical Center, Dallas, TX, ³Brigham and Women's Hospital, Boston, MA
*Purpose: Proteinuria after kidney transplantation is associated with worse allograft outcomes. B7-1 expression by podocytes has been linked to proteinuria by inducing podocyte migration which…
2022 American Transplant Congress
Sex Disparities in Access to Liver Transplant for Waitlisted Patients with Meld 40
D. C. Cron¹, H. Yeh¹, H. J. Braun², N. L. Ascher², D. C. Chang¹, J. T. Adler³
¹Surgery, Massachusetts General Hospital, Boston, MA, ²Surgery, University of California San Francisco, San Francisco, CA, ³Surgery and Perioperative Care, University of Texas at Austin, Austin, TX
*Purpose: Women with end-stage liver disease are less likely than men to receive a liver transplant, due in part to MELD’s reliance on creatinine and…
2022 American Transplant Congress
Role for Club Cell Secretory Protein in Inducing Exosomes and Activation of Immune Responses in Lung Transplanted Recipients for Cystic Fibrosis
R. Ravichandran¹, V. Kaza², R. Bremner¹, M. Smith¹, T. Mohanakumar¹
¹St. Joseph’s Hospital and Medical Center, Phoenix, AZ, ²University of Texas Southwestern, Dallas, TX
*Purpose: Our lab has demonstrated that lower club cell secretory protein leads to immune responses to donor HLA and lung self-antigens (Collagen V, Kα1 Tubulin),…
2022 American Transplant Congress
Pre-Transplant Frailty Predicts Infection After Liver Transplant in a Multi-Center Study of Older Adults
M. Malinis¹, M. Abidi², E. Benamu², N. Jakharia³, N. Law⁴, R. Sigler⁴, R. Nog⁵, S. Olivier⁵, S. Taimur⁶, N. Theodoropoulos⁷, J. Schaenman⁸
¹Yale SOM, New Haven, CT, ²Univ of CO, Aurora, CO, ³Stanford, Palo, Alto, CA, ⁴UCSD, San Diego, CA, ⁵Westchester Med Ctr, Westchester, NY, ⁶Mount Sinai SOM, New York, NY, ⁷Univ of MA, Worcester, MA, ⁸UCLA, Los Angeles, CA
*Purpose: Frailty is a complex multi-system characterization of reduced physiologic reserve and functional decline in older adults. At the time of transplant, frailty has been…
2022 American Transplant Congress
Hepatocyte SIRT1 Regulation of Apoptosis-Mediated Pyroptosis Cell Death in Mouse and Human Liver Transplantation
K. Kadono¹, H. Hirao¹, H. Kojima¹, K. J. Dery¹, X. Li², J. Kupiec-Weglinski¹
¹UCLA Medical Center, Los Angeles, CA, ²NIEHS, Durham, NC
*Purpose: Cold static preservation is a gold-standard in orthotopic liver transplantation (OLT). However, the role of hepatocyte-specific SIRT1 transcriptional regulation of cell death programs during…
2022 American Transplant Congress
Delivery of Extracellular Matrix Targeted Regulatory T Cells by Novel Nanofiber Coatings for Transplantation Therapies
L. Gallon¹, J. K. Carrow², J. He¹, Y. Sambandam¹, X. Lai¹, J. Mathew¹, L. C. Palmer², J. R. Leventhal¹, Z. Zhang¹, S. I. Stupp²
¹Surgery - Transplant, Northwestern University, Chicago, IL, ²Simpson Querrey Institute, Northwestern University, Chicago, IL
*Purpose: Regulatory CD4+CD25+FOXP3+ T cells (Tregs) have been shown to induce tolerance in transplantation models and can mitigate transplant rejection or injury following ischemic reperfusion…
2022 American Transplant Congress
Longitudinal Analysis of the Gut Microbiota Structure and Function After Renal Transplantation
A. Vaitkute¹, F. Yuen Chang¹, A. Greco², S. Chong¹, H. Mahdi³, M. Bajaj-Elliott², A. Pesenacker¹, R. Motallebzadeh¹
¹Institute of Immunity and Transplantation, UCL, London, United Kingdom, ²Institute of Child Health, UCL, London, United Kingdom, ³Department of Renal Medicine, UCL, London, United Kingdom
*Purpose: Despite marked improvements in outcomes after renal transplantation, graft loss from alloimmune pathology and adverse side effects including urinary tract infections and diarrhoea remain…
2022 American Transplant Congress
Specificity and Avidity of Donor MHC-Specific B Cells in Naive, Rejecting and Tolerant Mice
I. Sayin¹, S. Khiew², D. Yin¹, P. Sage³, C. B. Cavazzoni³, R. King⁴, A. Chong¹
¹Department of Surgery, University of Chicago, Chicago, IL, ²Merck, Boston, MA, ³Brigham and Women's Hospital, Boston, MA, ⁴Department of Microbiology, University of Alabama, Birmingham, AL
*Purpose: Antibody-mediated rejection is recognized as an important mediator of graft loss in the clinic, and the induction of donor-specific B cell tolerance may contribute…