ATC Abstracts

American Transplant Congress abstracts

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  • 2022 American Transplant Congress

    Acute Tubular Injury and Necrosis Do Not Lead to Meaningful Elevations in Donor-Derived Cell-Free DNA (dd-cfDNA)

    S. R. Allam1, M. Cooper2, D. Kumar3, T. Maw4, A. Wiseman5, P. Chuang6, G. Shekhtman7, N. Agrawal7, J. Zeng7, E. Huang8

    1Medical City Transplant Institute, Fort Worth, TX, 2Medstar Georgetown Transplant Institute, Washington, DC, 3Virginia Commonwealth University, Richmond, VA, 4University of Southern California, Los Angeles, CA, 5Centura Health, Denver, CO, 6Metrolina Nephrology, Charlotte, NC, 7CareDx, Brisbane, CA, 8Cedars-Sinai Medical Center, Los Angeles, CA

    *Purpose: Associations between non-rejection histologic diagnoses and dd-cfDNA have not been extensively characterized. We explored these associations in kidney transplant recipients enrolled in the Kidney…
  • 2022 American Transplant Congress

    Aftercare for Organ Donor Families: A Content Analysis of Organ Procurement Organization Family Services and Educational Materials

    J. Akhtar1, C. Sidoti1, S. Klitenic1, T. Storch2, E. Hughes2, C. Hagan3, A. Helman3, I. Johnson3, K. Vanterpool1, H. Sung1, L. Zeiser1, M. Levan1

    1Johns Hopkins, Baltimore, MD, 2Taylor's Gift Foundation, Coppell, TX, 3Living Legacy Foundation, Baltimore, MD

    *Purpose: Following a sudden and tragic loss, organ donor families’ members experience grief, and may even develop prolonged grief disorder. All US organ procurement organizations…
  • 2022 American Transplant Congress

    Long-Term Effects of Conversion from Calcineurin Inhibitors to Sirolimus for the Recipients with Low Immunological Risk in Renal Allograft

    Q. Wu, J. Chen, D. Cheng, X. Ni, X. Li, K. Xie, W. Jiqiu

    National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University Jinling School of Medicine, Nanjing, China

    *Purpose: To observe the long-term effects and prognosis of conversion from calcineurin inhibitors (CNIs) to sirolimus in biopsy-proven low immunological risk renal transplant recipients (RTRs).*Methods:…
  • 2022 American Transplant Congress

    Association Between De Novo Donor Specific Antibody and Tacrolimus Trough Levels in Long Term Follow Up Renal Transplantation

    N. Fujiyama1, M. Saito2, R. Yamamoto2, R. Sagehashi2, T. Saito2, Y. Aoyama2, K. Numakura2, T. Habuchi2, S. Satoh1

    1Center for Kidney Disease and Transplantation, Akita University Hospital, Akita, Japan, 2Department of Urology, Akita University Graduate School of Medicine, Akita, Japan

    *Purpose: In this study, we aimed to identify the risk factors contributing to the development of donor-specific anti-HLA antibody (DSA) during long-term follow-up of patients…
  • 2022 American Transplant Congress

    Kidney Allograft Injury is Reflected in the DNA Cargo of Urinary Extracellular Vesicles

    I. Sedej1, M. Štalekar2, M. Tušek Žnidarič2, K. Goričar3, N. Kojc4, P. Kogovšek2, V. Dolžan3, M. Lenassi3, M. Arnol1

    1Department of Nephrology, University Medical Centre Ljubljana, Ljubljana, Slovenia, 2Department of Biotechnology and Systems Biology, National Institute of Biology, Ljubljana, Slovenia, 3Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia, 4Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

    *Purpose: Following cell injury, donor-derived cell-free DNA (ddcfDNA) is increased in the urine of kidney transplant recipients. DNA containing urinary extracellular vesicles (uEVs) are relevant…
  • 2022 American Transplant Congress

    Evaluating Long Term Outcomes in Kidney Transplant Patients with TruGraf Gene Expression and TRAC Dd-cfdna in the TRULO Study

    P. West-Thielke, W. Ally, J. Hickey, L. Stach, J. Fleming, T. Cober, A. Kawano, I. Agboli, C. Miller, J. Holman

    Eurofins Transplant Genomics, Framingham, MA

    *Purpose: The aim of this study is to evaluate long term clinical outcomes in kidney transplant patients undergoing non-invasive rejection monitoring with the OmniGraf® biomarker…
  • 2022 American Transplant Congress

    Can Fibroscan Evaluation Of A Liver Predict Transplantability As Accurately As A Biopsy?

    S. J. Sander1, M. Moncure2

    1Organ Procurement, Midwest Transplant Network, Westwood, KS, 2Midwest Transplant Network, Westwood, KS

    *Purpose: Liver transplants are essential procedures that can impact a patient with chronic liver disease’s overall survival. Historically liver biopsies are the gold standard in…
  • 2022 American Transplant Congress

    Pegylated Lacritin N-104 Promotes Mouse Islet Stabilization and Prevents Diabetes Progression in the Non-Obese Diabetic (NOD) Mouse Model

    M. Ma1, P. Chhabra1, G. Laurie2, K. L. Brayman1

    1Department of Surgery, University of Virginia Health System, Charlottesville, VA, 2Department of Cell Biology, University of Virginia Health System, Charlottesville, VA

    *Purpose: To investigate if PEGylated Lacritin N-104 (PEG N-104) prevents the progression of type 1 diabetes (T1D) in the NOD mouse.*Background: Lacritin is a multifunctional…
  • 2022 American Transplant Congress

    Lucas Device Assisted Uncontrolled Dcd Kidney Transplantation – A Feasible but Underutilized Option in the United States

    S. Nagaraju, S. Vaishnav, R. Savilla, M. Moore, J. B. Africa

    Renal Transplant, Charleston Area Medical Center, Charleston, WV

    *Purpose: Uncontrolled DCD (uDCD) procurement involves either normo-thermic or hypothermic regional perfusion to reduce ischemic injury. We report a series of successful kidney transplant utilizing…
  • 2022 American Transplant Congress

    Dual Deceased Donor Kidney Transplants: Maximizing Utilization of Suboptimal Kidneys

    S. Nagaraju, S. Vaishnav, K. Boggs, T. Cook, A. Jones, J. B. Africa

    Renal Transplant, Charleston Area Medical Center, Charleston, WV

    *Purpose: To demonstrate that dual transplant of marginal kidneys is an underutilized strategy to minimize discard rates and mitigate organ shortage.*Methods: We compared dual kidney…
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