Am J Transplant, Volume 22, Suppl 3 Archives - Page 36 of 190 - ATC Abstracts

2022 American Transplant Congress
Randomized, Phase 4 Study Evaluating the Pharmacokinetics and Tolerability of the New Tacrolimus Tablet Formulation (Tacrobell Tab) in Kidney Transplant Recipients
A. Han¹, E. Cho¹, H. Y. Woo¹, C. Ara¹, H. Lee², Y. Kim³, Y. Park⁴, J. Oh⁴, S. Min¹, J. Ha¹
¹Department of Surgery, Seoul National University College of Medicine, Seoul, Korea, Republic of, ²Seoul National University Hospital, Seoul, Korea, Republic of, ³Department of Nephrology, Seoul National University College of Medicine, Seoul, Korea, Republic of, ⁴Department of Clnical Pharmacology, Seoul National University Hospital, Seoul, Korea, Republic of
*Purpose: Previous twice-a-day tacrolimus formulations available were capsular and of limited dose formulations (0.5mg, 1mg). Recently a new tablet formulation of tacrolimus with more diverse…
2022 American Transplant Congress
The Promise Of Tolerance In Living Donor Kidney Transplant (LDKT): A Retrospective, Real-world Assessment Of The Safety And Efficacy Of LDKT With FCR001 Investigational Cell-therapy Compared With Standard Of Care (SOC)
N. Krieger¹, J. R. Leventhal², B. Ho³, M. Richards⁴, D. Schaumberg⁴, S. Ildstad⁵, D. Axelrod⁶
¹Talaris Therapeutics, Inc, Wellesley, MA, ²SURGERY, Northwestern Medicine, Chicago, IL, ³Comprehensive Transplant Ctr, Chicago, IL, ⁴Evidera, Bethesda, MD, ⁵Talaris Therapeutics, Inc., Louisville, KY, ⁶University of Iowa, Iowa City, IA
*Purpose: FCR001 (FCR) is a cell therapy derived from mobilized donor PBMCs including hematopoietic progenitor cells, facilitating cells, and αβ T cells, intended to establish…
2022 American Transplant Congress
Analytical Evaluation and Comparison to STR of an Accurate and Sensitive Microchimerism Monitoring Tool for Liver Transplant Recipients
A. S. Kothari¹, C. Egidio¹, J. Miles², N. Gulbahce¹, S. Dholakia³, M. Grskovic⁴
¹Clinical Development, CareDx, South San Francisco, CA, ²Medical Affairs, CareDx, Brooklyn, NY, ³Medical Affairs, CareDx, South San Francisco, CA, ⁴CareDx, Brisbane, CA
*Purpose: Peripheral blood chimerism is associated with clinically relevant events post liver transplantation (LT). Accurate quantification of donor chimerism in LT recipients with ultra-sensitive chimerism…
2022 American Transplant Congress
A Three-gene Peripheral Blood Potential Diagnosis Signature Associated With Autophagy For Antibody-mediated Rejection In Renal Transplantation
Y. Wang, Y. Xu, H. Zhang, X. Hu
Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
*Purpose: Antibody-mediated rejection (AMR) is emerging as a major cause of graft loss in renal transplantation. Nowadays, non-invasive diagnosis of AMR with high accuracy is…
2022 American Transplant Congress
Ex Vivo End Ischemic Hypothermic Oxygenated Perfusion (hope) Versus Static Cold Storage Prior To Liver Transplantation – Preliminary Results Of The Bridge To Hope Pivotal Multicenter Randomized Controlled Clinical Trial On The Safety And Effectiveness Of The Vitasmart Liver Machine Perfusion System (clinicaltrials.gov: Nct05045794)
D. J. Reich¹, A. Schlegel², M. Rizzari³, D. Foley⁴, M. DeVera⁵, W. Chapman⁶, G. Roll⁷, A. Saharia⁸, C. Quintini⁹, S. Florman¹⁰, S. Merani¹¹, S. Mao¹², A. Pinna¹³, M. Akoad¹⁴, C. Kubal¹⁵, S. Alexopoulos¹⁶, H. Bohorquez¹⁷
¹Drexel University, Philadelphia, PA, ²Careggi U, Florence, Italy, ³Henry Ford, Detroit, MI, ⁴U Wisconsin, Madison, WI, ⁵Loma Linda, Loma Linda, CA, ⁶Washington U, Saint Louis, MO, ⁷UCSF, SF, CA, ⁸Methodist, Houston, TX, ⁹Cleveland Clinic, Cleveland, OH, ¹⁰Mount Sinai, NY, NY, ¹¹U Nebraska, Omaha, NE, ¹²Mayo, Jacksonville, FL, ¹³Cleveland Clinic, Weston, FL, ¹⁴Lahey, Burlington, MA, ¹⁵Indiana U, Indianapolis, IN, ¹⁶Vanderbilt, Nashville, TN, ¹⁷Ochsner, New Orleans, LA
*Purpose: Ex vivo end ischemic hypothermic oxygenated machine perfusion (HOPE) is a simple technique to improve liver transplant (LT) results and the donor shortage. HOPE…
2022 American Transplant Congress
Functional Recellularized Patient Derived Endothelium; A Human Vascular Graft Approach
H. Tejeda Mora¹, J. Willemse², Y. den Hartog¹, I. Schurink², M. M. Verstegen², J. de Jonge², R. C. Minnee², M. W. van den Hoogen², C. C. Baan¹, L. J. van der Laan², M. J. Hoogduijn¹
¹Transplant Institute - Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands, ²Transplant Institute - Department of Surgery, Erasmus Medical Center, Rotterdam, Netherlands
*Purpose: In transplantation, the endothelial lining is the first barrier between the donor organ and recipient immune system. Damaged endothelium exposes extracellular matrix (ECM) molecules…
2022 American Transplant Congress
Single Cell RNAseq Analysis of Liver Transplant Rejection Reveals Highly Restricted TCR Clonal Expansion of Tissue-Resident Memory CD8⁺ T Cells That Persist Despite Corticosteroids and ATG Therapy
A. L. Peters¹, G. Begum¹, K. Roskin², E. Woodle³, D. Hildeman⁴
¹Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Department of Bioinformatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Department of Surgery, University of Cincinnati, Cincinnati, OH, ⁴Department of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
*Purpose: Conventional therapy for liver transplant rejection (corticosteroids and ATG) has remained unchanged for six decades, and is not infrequently met with treatment failure. Here,…
2022 American Transplant Congress
Selective Vascular Decellularization and Endothelial Cells Replacement as a Strategy to Reduce Reperfusion Injury in Bioartificial Organs
G. Haeublein¹, G. Lombardi¹, F. Caro¹, R. Carla¹, D. Guerrieri¹, C. Incardona², D. Casadei³, E. Chuluyan¹
¹CEFYBO, Buenos Aires, Argentina, ²GADOR S.A., Buenos Aires, Argentina, ³Fundación Argentina de Trasplante, Tercer Milenio, Buenos Aires, Argentina
*Purpose: The number of kidney transplants performed each year cannot meet the increasing demand of these organs. Several strategies aim to increasing the offer of…
2022 American Transplant Congress
Enhancing Early Nerve Regeneration from Reconstruction of a Segmental Nerve Injury with Polyethylene Glycol
A. Bernal¹, C. Hinshaw¹, J. Hinshaw¹, C. Yang², S. Margaux¹, W. Zhang¹, J. Nuelle¹, C. Sabbag¹, G. Bittner², J. Shores³, E. Weitzel¹, J. Alderete¹
¹RESTOR FUSE Nerve Reconstruction Consortium, US Army Institute of Surgical Research/59th MDW, San Antonio, TX, ²University of Texas at Austin, Austin, TX, ³John Hopkins University, Baltimore, MD
*Purpose: Despite advancements in understanding and treating peripheral nerve injuries (PNIs), restoration of lost motor and sensory functions remain poor using current methods of clinical…
2022 American Transplant Congress
Gsk3beta Regulates the Resolution of Liver Ischemia Reperfusion Injury via MerTK
H. Zhang¹, M. Ni², J. Zhang¹, R. Busuttil¹, J. Kupiec-Weglinski¹, W. Li³, X. Wang², Y. E. Zhai¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, ³China-Japan Union Hospital of Jilin University, JiLing, China
*Purpose: We have shown previously that glycogen synthase kinase β (Gsk3β) regulates liver inflammatory activation against ischemia/reperfusion injury (IRI). The question of whether it also…