Am J Transplant, Volume 22, Suppl 3 Archives - Page 35 of 190 - ATC Abstracts

2022 American Transplant Congress
Overexpression of Human Ectonucleoside Triphosphate Diphosphohydrolase 1 (entpd1; Hcd39) Did Not Afford Significant Protection on Porcine Endothelial Cells
R. Matheson¹, B. Gonzalez Nolasco¹, K. Deng¹, R. Garofalo¹, N. Serifis¹, T. M. Coe¹, C. Rhatigan¹, D. Gil¹, D. Cloonan¹, K. Lee¹, K. Hall², M. Youd², J. F. Markmann¹, S. C. Robson³
¹Transplantation surgery research, Massachusetts General Hospital, Boston, MA, ²eGenesis Bio, Cambridge, MA, ³Beth Israel Deaconess Medical Center, Boston, MA
*Purpose: The thromboregulatory and anti-inflammatory potential of human CD39 (hCD39) makes it a gene of interest in xenotransplantation. In porcine endothelium, CD39 activity is generally…
2022 American Transplant Congress
Prospective Evaluation of Donor-Derived Cell-Free DNA (dd-cfDNA) in Monitoring Response to Anti-Rejection Treatment in Kidney Transplant Recipients with Indication Biopsy
L. Benning¹, A. Fink², F. Kälble¹, C. Speer¹, C. Nusshag¹, M. Zeier¹, C. Süsal³, C. Morath¹, T. Tran²
¹Department of Nephrology, University Hospital Heidelberg, Heidelberg, Germany, ²Transplantation Immunology, Institute of Immunology, University Hospital Heidelberg, Heidelberg, Germany, ³Transplant Immunology Research Center of Excellence, Koç University Hospital, Istanbul, Turkey
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) is a marker of allograft injury in kidney transplant recipients (KTR). Little is known about the possible use of dd-cfDNA…
2022 American Transplant Congress
Development of a Culturally Sensitive Chatbot to Inform Living Donor Candidates of African Ancestry About Apol1 Genetic Testing
E. J. Gordon¹, P. Waite², J. Gacki-Smith², D. Duquette³, A. Agrawal¹, J. Friedewald¹, S. Savage⁴, E. Simmons⁵, M. Cooper⁶, A. Gilbert⁶, C. Wicklund⁷
¹Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Center for Health Services and Outcomes Research, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Invitae, Inc, San Francisco, CA, ⁵Invitae, San Francisco, CA, ⁶Surgery, Georgetown University Medical Center, Washington, DC, DC, ⁷Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: Living kidney donor candidates of African ancestry are increasingly asked to undergo Apolipoprotein L1 (APOL1) genetic testing to better understand their risk of kidney…
2022 American Transplant Congress
Incidence of Dapsone-Induced Methemoglobinemia in Solid Organ Transplant Recipients
D. Quan¹, R. Gordon¹, J. Lee¹, D. Khoshabafard², A. Han¹
¹Pharmacy, UCSF Medical Center, San Francisco, CA, ²Clinical Phamacy, UCSF School of Pharmacy, San Francisco, CA
*Purpose: The purpose of this study was to determine the incidence of dapsone-induced methemoglobinemia in solid organ transplant recipients.*Methods: This was a single-center retrospective cohort…
2022 American Transplant Congress
Early Outcomes of Single Dose Eculizumab for Abo-Incompatible Living Donor Renal Transplantation
K. Heagler, M. Campara, P. Di Cocco, S. Gaitonde, I. Tang, J. Almario Alvarez, M. Spaggiari, J. Benken, C. S. Muran, B. Valdepenas, D. Pierce, I. Tzvetanov, E. Benedetti
UI Health, Chicago, IL
*Purpose: Use of ABO-incompatible (ABOi) donors increases access to living donor renal transplantation (LDRT). Conventional desensitization with plasmapheresis (PLEX) allows safe ABOi transplantation when pre-transplant…
2022 American Transplant Congress
Manufactured Organ Procurement Facility Collaboration and Authorization Approach for Xenotransplant Research
E. P. Weldon, N. S. Lawson, B. E. Sullivan, B. S. Parent, C. L. Deterville, R. A. Dieter, R. A. Montgomery
NYU Langone Health-Transplant Institute, New York, NY
*Purpose: A Manufactured Organ Research Facility (MORF) was created at our institution to provide a safe environment for testing xenograft organs in deceased brain dead…
2022 American Transplant Congress
Liver Transplant Recipient History of Criminality: Impact on Clinical Outcomes
M. M. French¹, R. Mangus¹, R. Holmes¹, A. Krause¹, J. Sumner¹, C. Kubal¹, B. Ekser², P. Mihaylov³, A. Lutz⁴, J. Fridell⁵
¹Department of Surgery, Indiana University, Indianapolis, IN, ²Surgery, Indiana University - Transplant Surgery, Indianapolis, IN, ³Department of Surgery, Indiana Univ School of Medicine, Indianapolis, IN, ⁴Department of Surgery, Indiana University, Fishers, IN, ⁵Department of Surgery, Indiana University School of Medicine, Indianapolis, IN
*Purpose: Health disparities are present in transplantation, just as in other areas of medicine. This is a retrospective review of liver transplant (LT) recipients to…
2022 American Transplant Congress
Direct Procurement of Heart and Lungs from a Controlled DCD Donor with Ongoing Abdominal Normothermic Regional Perfusion (aNRP) – A Synchronized Retrieval
M. Husain¹, A. Jothidasan¹, C. Zeschky¹, M. Osman², M. Berman², R. Gaurav³, A. Butler³, C. Watson³, B. Stutchfield⁴, I. Currie⁵, G. Oniscu⁵, J. Dunning¹, U. Stock¹
¹Department of Cardiothoracic Surgery, Transplantation and MCS, Royal Brompton & Harefield Hospitals Part of Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom, ²Department of Heart and Lung Transplant, Royal Papworth Hospital, Cambridge, United Kingdom, ³Roy Calne Transplant Unit, Department of Surgery, Addenbrookes Hospital, Cambridge University NHS Trust, Cambridge, United Kingdom, ⁴Edinburgh Transplant Centre, Royal Infirmary of Edinburgh, Edinburgh, Edinburgh, United Kingdom, ⁵Edinburgh Transplant Centre, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
*Purpose: With the increased number of aNRP in controlled DCD donors comes a high demand for techniques to directly procure cardiothoracic organs during the aNRP.…
2022 American Transplant Congress
Mhealth Coaching Improves Patient Activation and Nutritional Behaviors in Diverse Renal Transplant Recipients
M. Pollack¹, N. Stauffer², H. Lee², I. Satoru², M. Ellis³, C. Diamantidis³, S. Docherty⁴, E. T. Chambers⁵
¹Psychiatry, Duke University, Durham, NC, ²Biostatistics, Duke University, Durham, NC, ³Internal Medicine, Duke University, Durham, NC, ⁴School of Nursing, Duke University, Durham, NC, ⁵Pediatrics, Duke University, Durham, NC
*Purpose: Kidney transplant recipients who are not actively engaged in their care and lack self-management skills have poor transplant outcomes. These suboptimal outcomes are disproportionately…
2022 American Transplant Congress
Interleukin-31 (IL-31) and Leukemia Inhibitory Factor (LIF) Are Upregulated in Acute Rejection of Kidney Allograft
I. Striz, L. Krupickova, M. Fialova, M. Novotny, E. Cecrdlova, O. Viklicky
Institute for Clinical and Experimental Medicine, Praha, Czech Republic
*Purpose: Interleukin-31 (IL-31) and leukemia inhibitory factor (LIF) belong to the IL-6 cytokine family clustered by their pro-inflammatory properties and a shared signaling pathway of…