Am J Transplant, Volume 22, Suppl 3 Archives - Page 34 of 190 - ATC Abstracts

2022 American Transplant Congress
IL-15 Signaling is Required for the Maintenance of Tissue Resident Memory T Cells in Chronic Allograft Rejection
R. Tieu¹, Q. Zeng¹, D. Zhao¹, A. Williams¹, J. Yun Tso², F. Lakkis¹, J. Yun Tso²
¹Starzl Transplantation Institute, Pittsburgh, PA, ²JN Biosciences, Mountain View, CA
*Purpose: Currently, no immunotherapies have been clinically proven to prevent or treat chronic rejection. IL-15 is known to support memory T cell homeostasis. However, it…
2022 American Transplant Congress
Induction of Tacrolimus Clearance by Steroids Varies by Cyp3a5 Genotype in Kidney Transplant Recipients: A Drug-Drug-Gene Interaction
P. A. Jacobson¹, A. Saqr¹, M. Al-Kofahi¹, D. P. Schladt², W. Guan³, W. S. Oetting¹, R. Mannon⁴, C. R. Dorr⁵, R. P. Remmel¹, G. C. Onyeaghala⁶, B. Wu³, A. K. Israni⁷, A. Matas⁸
¹Univ of MN, College of Pharmacy, Minneapolis, MN, ²Hennepin Health Research Institute, Minneapolis, MN, ³Univ of MN, Biostatistics, Minneapolis, MN, ⁴Univ of Nebraska, Dept of Medicine, Omaha, NE, ⁵Hennepin Health Research Institute and Dept of Medicine, Minneapolis, MN, ⁶Hennepin Healthcare Research Institute, Minneapolis, MN, ⁷Hennepin Health Dept of Medicine and Univ of MN, Minneapolis, MN, ⁸University of MN, Dept of Surgery, Minneapolis, MN
*Purpose: Tacrolimus (TAC) is the primary immunosuppressant used in organ transplantation. TAC is a substrate for CYP3A4/5. These enzymes are inhibited or induced by multiple…
2022 American Transplant Congress
Optimal Intervention for Initial Treatment of Anastomotic Biliary Complications After Living Donor Liver Transplantation
M. Kim¹, S. Hong¹, H. Woo¹, J. Cho², J. Lee², K. Yoon¹, Y. Choi³, N. Yi⁴, K. Lee³, K. Suh¹
¹Surgery, Seoul National University College of Medicine, Seoul, Korea, Republic of, ²Department of Surgery, Seoul National University Hospital, Seoul, Korea, Republic of, ³Seoul National University, Seoul, Korea, Republic of, ⁴Seoul National University College of Medicine, Seoul, Korea, Republic of
*Purpose: Endoscopic retrograde cholangiopancreatography (ERCP) or percutaneous transhepatic biliary drainage (PTBD) may be performed in patients with anastomotic biliary complications (ABC) after living donor liver…
2022 American Transplant Congress
Development of a Comprehensive Banff Automation System for Kidney Allograft Precision Diagnostics
D. Yoo¹, J. Gueguen¹, G. Divard¹, M. Raynaud¹, V. Goutaudier¹, M. Rabant¹, M. Haas², M. Mengel³, O. Aubert¹, A. Loupy¹
¹Paris Transplant Group, Paris, France, ²Cedars-Sinai Medical Center, Dept. of Pathology, West Hollywood, CA, ³University of Alberta, Edmonton, AB, Canada
*Purpose: Since 1991, the Banff classification has been the gold standard for kidney allograft rejection diagnostics. However, with time, the classification has become complex with…
2022 American Transplant Congress
Metagenomic Next-Generation Sequencing Reveals the Profile of Viral Infections in Kidney Transplant Recipients During the Covid-19 Pandemic
X. Tian, W. Duan, C. Zhang, X. Wu, T. Yan
Henan Province People's Hospital, Zhengzhou, Henan Province, China
*Purpose: To study the clinical application of metagenomic next-generation sequencing (mNGS) in the detection of viral infections in kidney transplant recipients (KTRs) during the COVID-19…
2022 American Transplant Congress
Association of Trugraf GEP with Clinical and Histological Outcomes in a Multicenter Cohort (TOGETHER Study)
R. Heilman¹, W. Park², M. Mai³, B. Smith², R. First⁴, J. Fleming⁴, P. West-Thielke⁴, J. Holman⁴, M. Stegall²
¹Mayo Clinic, Phoenix, AZ, ²Mayo Clinic, Rochester, MN, ³Mayo Clinic, Jacksonville, FL, ⁴Transplant Genomics, Framingham, MA
*Purpose: The purpose of this study was to validate the association of TruGraf GEP with clinical endpoints in a real-world cohort.*Methods: This was a multicenter…
2022 American Transplant Congress
Use of Organ-Specific Chimeric Antigen Receptor Promotes Liver Recruitment of Regulatory T Cells
E. Landmann¹, P. Ruiz¹, A. Kurt¹, E. Kodela¹, M. Martinez-Llordella², A. Sanchez-Fueyo¹
¹King's College London, London, United Kingdom, ²Quell Therapeutics, London, United Kingdom
*Purpose: Owing to their potent immune-modulatory properties, regulatory T cells (Tregs) have been explored as novel cell therapy to induce allograft tolerance, with first clinical…
2022 American Transplant Congress
Modern Medicine Needs Modern Technology Tools
Z. S. Soltani,, S. Soltani
Ochsner Foundation Hospital, New Orleans, LA
*Purpose: Dd-cfDNA has been used as a non-invasive biomarker for allograft injury and has been shown to detect subclinical rejection with higher predictive power compare…
2022 American Transplant Congress
Older Donor Age is Associated with Worse Living Donor Liver Transplantation Outcomes in a National US Cohort
M. Kanneganti¹, K. M. Olthoff², T. Bittermann³
¹Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, ²Department of Surgery, University of Pennsylvania, Philadelphia, PA, ³Division of Gastroenterology and Hepatology, University of Pennsylvania, Philadelphia, PA
*Purpose: To evaluate the impact of increasing living donor (LD) age on living donor liver transplantation (LDLT) outcomes in the U.S.*Methods: A retrospective cohort of…
2022 American Transplant Congress
A Qualitative Comparison of Declined Hispanic and Non-Hispanic Living Liver Donor Candidates at a High-Volume Urban Transplant Center
D. Toy¹, B. Horwich¹, A. Mulgaonkar¹, A. Padilla², J. L. Dodge³, N. Kaur⁴, H. Han³
¹Department of Medicine, University of Southern California, Los Angeles, CA, ²USC Transplant Institute, University of Southern California, Los Angeles, CA, ³Division of Gastrointestinal and Liver Diseases, University of Southern California, Los Angeles, CA, ⁴Department of Surgery, University of Southern California, Los Angeles, CA
*Purpose: To compare Hispanic and non-Hispanic living liver donor candidates who were declined by a multidisciplinary selection committee at a large urban transplant center.*Methods: The…