Am J Transplant, Volume 22, Suppl 3 Archives - Page 33 of 190 - ATC Abstracts

2022 American Transplant Congress
A Novel Method for Ex Vivo Stimulation of Mesenchymal Stem Cells via Invariant Natural Killer T Cell Activation with ɑ-galactosylceramide
R. Ishii¹, E. Kawaguchi¹, T. Yamakawa¹, H. Ishigooka¹, T. Ikeda¹, R. Ishiyama¹, K. Saiga¹, T. Takagi¹, Y. Ishii², K. Tanabe¹
¹Tokyo Women's Medical University, Tokyo, Japan, ²Department of Immunological Diagnosis, Juntendo University Graduate School of Medicine, Tokyo, Japan
*Purpose: Mesenchymal stem cells (MSCs) typically exhibit unique regenerative and immunomodulatory properties when exposed to proinflammatory cytokines. Invariant natural killer T (iNKT) cells are known…
2022 American Transplant Congress
Characterization Of Gzmb+ Bregs Using Single Cell Rnaseq
N. Sailliet, H. Le Mai, A. Dupuy, C. Fourgeux, M. Chesneau, J. Poschmann, R. Danger, S. Brouard
CRT2I INSERM UMR1064, Nantes, France
*Purpose: Granzyme B (GZMB)+ B cells are increased in blood from transplanted patients who tolerate a kidney graft without immunosuppressive treatment. We demonstrated that these…
2022 American Transplant Congress
Kidney Nonprocurement in Deceased Donors with Acute Kidney Injury
K. Yu¹, K. King¹, S. Husain¹, J. Stevens¹, C. Parikh², S. Mohan¹
¹Division of Nephrology, Columbia University Medical Center, New York, NY, ²Division of Nephrology, Johns Hopkins School of Medicine, Baltimore, MD
*Purpose: Deceased donor acute kidney injury (AKI) is associated with high rates of kidney discard by transplant centers, despite evidence of excellent post-transplant outcomes. High…
2022 American Transplant Congress
Influence of Converting Kidney Transplant Recipients with High Tacrolimus Variability to the Once Daily LCP Tac Formulation
D. Taber, F. Bartlett, N. Patel, T. Sprague, S. Patel, J. Newman, E. Andrade, N. Rao, A. Posadas, V. Rao, M. Casey, D. Dubay, V. Rohan
Med Univ of South Carolina, Charleston, SC
*Purpose: Tacrolimus (Tac) is the cornerstone of immunosuppression used in kidney transplant recipients (KTRs). Tac high variability, low time in therapeutic range and non-adherence are…
2022 American Transplant Congress
Recipient and Grafts Outcomes in Simultaneous Kidney and Pancreas Transplantation with Steroid Avoidance in the United States
A. Cerise¹, A. Dinesh², V. Humphreville², S. Jackson³, R. Kandaswamy², S. Riad⁴
¹Surgery, University of Minnesota, Minnesota, MN, ²Surgery, University of Minnesota, Minneapolis, MN, ³Analytics, MHealth-Fairview, Minneapolis, MN, ⁴Medicine, University of Minnesota, Eden Prairie, MN
*Purpose: Steroid avoidance in kidney transplantation has been proven non-inferior. Data on steroid avoidance in simultaneous pancreas-kidney (SPK) is scant.*Methods: We utilized the Scientific Registry…
2022 American Transplant Congress
Differences in Medication Adherence Between Preemptive and Post-Dialysis Young Kidney Transplant Recipients
Y. Vaisbourd¹, E. Samson², A. De Simone², M. Dahhou², B. Foster³
¹Pediatrics, McGill University, Montréal, QC, Canada, ²McGill University, Montréal, QC, Canada, ³Montreal Children's Hospital, Montreal, QC, Canada
*Purpose: The mechanisms underlying the superior graft survival associated with pre-emptive kidney transplantation, compared with transplantation following a period of dialysis, are unknown. Selection for…
2022 American Transplant Congress
Kidney Grafts with Poor 24-Month Function Present Upregulated Immune Activity at Pre-Transplantation
E. Bardhi¹, K. Archer², D. Maluf¹, J. McDaniels¹, T. Rousselle¹, E. Akalin³, T. Mueller⁴, V. Mas¹
¹University of Maryland, Baltimore, MD, ²Ohio State University, Columbus, OH, ³Montefiore Medical Center, Bronx, NY, ⁴University Hospital Zürich, Zürich, Switzerland
*Purpose: A transcriptomic profile serves as a snapshot of the temporary cell state and thus, analyzing pretransplant kidney biopsies can provide detailed information on the…
2022 American Transplant Congress
Early Mortality After Liver Transplant is Associated with Pre-Transplant Alterations in Monocyte Phenotype and Gene Expression
L. Jin¹, A. Lemenze², G. Panayotova¹, S. Simonishvili¹, Y. Qin¹, T. Ayorinde¹, G. Prakash¹, L. J. Minze³, F. Paterno¹, L. Brown¹, A. Amin¹, X. C. Li³, R. Ghobrial³, J. V. Guarrera¹, K. E. Lunsford¹
¹Department of Surgery, Rutgers New Jersey Medical School, Newark, NJ, ²Center for Immunity and Inflammation, Rutgers Biomedical and Health Sciences, Newark, NJ, ³J.C. Walter Jr. Center for Transplantation, Houston Methodist Hospital, Houston, TX
*Purpose: Persistence of pre-liver transplant (LT) immune dysfunction (immune frailty) significantly increases post-LT morbidity and mortality. We have identified a pre-LT biomarker panel, the liver…
2022 American Transplant Congress
A Decennial Summary of the OPTN Kidney Paired Donation Pilot Program
K. Gauntt¹, A. Toll¹, J. Musick¹, P. Kennealey², J. Kim³, T. Sandholm⁴, R. Leishman¹
¹United Network For Organ Sharing, Richmond, VA, ²University of Colorado Hospital, Aurora, CO, ³Keck Medicine of USC, Los Angeles, CA, ⁴Carnegie Mellon University, Pittsburgh, PA
*Purpose: The OPTN Kidney Paired Donation Pilot Program (KPDPP) is a national KPD system that has served the kidney transplant community for over 10 years.…
2022 American Transplant Congress
HLA-DQ Mismatches Are More Likely to Be Listed as Unacceptable Antigens After Renal Graft Failure in African American Recipients as Compared to Other Racial/Ethnic Groups
D. Isaacson¹, M. W. Gmeiner², V. Kosmoliaptsis³, J. D. Schold⁴, A. R. Tambur¹
¹Northwestern University, Chicago, IL, ²London School of Economics, London, United Kingdom, ³Cambridge University, Cambridge, United Kingdom, ⁴Cleveland Clinic, Cleveland, OH
*Purpose: Growing evidence suggests that donor-recipient mismatches at the HLA-DQ locus are the most immunogenic and pathogenic, evidenced by generation of DQ donor-specific antibodies (DSA).…