Am J Transplant, Volume 22, Suppl 3 Archives - Page 32 of 190 - ATC Abstracts

2022 American Transplant Congress
Kidney Allograft Injury is Reflected in the DNA Cargo of Urinary Extracellular Vesicles
I. Sedej¹, M. Štalekar², M. Tušek Žnidarič², K. Goričar³, N. Kojc⁴, P. Kogovšek², V. Dolžan³, M. Lenassi³, M. Arnol¹
¹Department of Nephrology, University Medical Centre Ljubljana, Ljubljana, Slovenia, ²Department of Biotechnology and Systems Biology, National Institute of Biology, Ljubljana, Slovenia, ³Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia, ⁴Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
*Purpose: Following cell injury, donor-derived cell-free DNA (ddcfDNA) is increased in the urine of kidney transplant recipients. DNA containing urinary extracellular vesicles (uEVs) are relevant…
2022 American Transplant Congress
Evaluating Long Term Outcomes in Kidney Transplant Patients with TruGraf Gene Expression and TRAC Dd-cfdna in the TRULO Study
P. West-Thielke, W. Ally, J. Hickey, L. Stach, J. Fleming, T. Cober, A. Kawano, I. Agboli, C. Miller, J. Holman
Eurofins Transplant Genomics, Framingham, MA
*Purpose: The aim of this study is to evaluate long term clinical outcomes in kidney transplant patients undergoing non-invasive rejection monitoring with the OmniGraf® biomarker…
2022 American Transplant Congress
Can Fibroscan Evaluation Of A Liver Predict Transplantability As Accurately As A Biopsy?
S. J. Sander¹, M. Moncure²
¹Organ Procurement, Midwest Transplant Network, Westwood, KS, ²Midwest Transplant Network, Westwood, KS
*Purpose: Liver transplants are essential procedures that can impact a patient with chronic liver disease’s overall survival. Historically liver biopsies are the gold standard in…
2022 American Transplant Congress
Tissue Engineering Scaffolds for Minimally Invasive Immunosurveillance of Acute Cellular Graft Rejection
R. R. Urie¹, D. Farris², A. Morris¹, E. Lombard¹, J. Z. Li³, D. Goldstein², L. Shea¹
¹Biomedical Engineering, University of Michigan, Ann Arbor, MI, ²Internal Medicine, University of Michigan, Ann Arbor, MI, ³Human Genetics, University of Michigan, Ann Arbor, MI
*Purpose: As there is no assay to predict the risk of acute cellular allograft rejection (ACAR), clinicians rely on protocol graft biopsy and aggressive, one-size-fits-all…
2022 American Transplant Congress
Cold Ischemic Time and Kidney Graft Failure; Mediation Through Delayed Graft Function
J. Miller¹, W. Irish², D. Sawinski³, A. Massie⁴, J. Snyder¹
¹Scientific Registry of Transplant Recipients, Minneapolis, MN, ²Department of Surgery, East Carolina University, Greenville, NC, ³Division of Nephrology and Hypertension, Weill Cornell Medical College, New York, NY, ⁴Division of Surgery, Johns Hopkins School of Medicine, Baltimore, MD
*Purpose: Delayed graft function (DGF) has been associated with decreased graft survival and prolonged cold ischemia time (CIT) has been proposed as a modifiable DGF…
2022 American Transplant Congress
Stem Cell Donor-Derived CPRA Better Reflects Sensitization Than Current CPRA
K. Lindblad¹, C. Murphey², P. Lalli³, J. Lunz⁴, L. Gragert⁵
¹UNOS, Richmnd, VA, ²Southwest Immunodiagnostics, Inc., San Antonio, TX, ³Carolinas Medical Center, Charlotte, NC, ⁴LifeLink Foundation Transplant Immunology Lab, Tampa, FL, ⁵Tulane University School of Medicine, New Orleans, LA
*Purpose: The OPTN Histocompatibility Committee proposes replacing the current calculated panel reactive antibody (CPRA), based on HLA haplotype frequencies from ~14,000 deceased kidney donors, with…
2022 American Transplant Congress
Cold Ischemia Time is More Critical for Older Donor Kidney Survival: A Machine Learning Approach
J. Kim, J. Ahn, A. Massie, D. Segev, S. Bae
Johns Hopkins, Baltimore, MD
*Purpose: Increasing utilization of kidneys from older donors is a potential solution to mitigate the organ shortage. However, older donor age is a risk factor…
2022 American Transplant Congress
Donor and Recipient Age Matching for Kidney Transplantation: A Machine Learning Approach
J. Kim, J. Ahn, A. Massie, D. Segev, S. Bae
Johns Hopkins, Baltimore, MD
*Purpose: Under the concept of ‘longevity matching,’ the Kidney Allocation System favors matching younger deceased donors with younger kidney transplant (KT) candidates. However, it remains…
2022 American Transplant Congress
Association Between Histopathological Features on Implantation Renal Biopsies and Graft Outcomes and Kdpi
C. Khor, S. McGinn, C. Fisher, R. Yang, K. Richards, K. Muir, J. Lu
Nephrology, Royal North Shore Hospital, Sydney, Australia
*Purpose: The global shortage of organs and the increasing use of marginal kidneys for transplantation necessitates an accurate assessment of deceased donor kidneys. The kidney…
2022 American Transplant Congress
Waitlisted and Transplant Patient Perspectives on Expanding Access to Deceased Donor Kidney Transplants
C. Rosaasen¹, N. Rosaasen², R. Mainra³, A. Trachtenberg⁴, J. Ho⁵, C. Parsons⁶, S. Delaney⁶, H. Mansell⁷
¹Johnson Shoyama School of Public Policy, University of Saskatchewan, Saskatoon, SK, Canada, ²Saskatchewan Transplant Program, Saskatchewan Health Authority, Saskatoon, SK, Canada, ³Division of Nephrology, Department of Medicine, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada, ⁴, Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada, ⁵Department of Internal Medicine and Department of Immunology, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada, ⁶Canadian Blood Services, Edmonton, AB, Canada, ⁷University of Saskatchewan, Saskatoon, SK, Canada
*Purpose: A concerning number of kidneys (expanded donor criteria, extended criteria, or marginal kidneys) are discarded yearly, and novel solutions are needed to solve the…