Am J Transplant, Volume 22, Suppl 3 Archives - Page 32 of 190 - ATC Abstracts

2022 American Transplant Congress
Deficiency of Antibody-Suppressor CXCR5⁺CD8⁺ TCells (Not CD4⁺ T_regs) Drive High Alloantibody Production in CCR5 KO Kidney Transplant Recipients
J. L. Han¹, J. M. Zimmerer¹, Q. Zeng², S. Chaudhari¹, C. K. Breuer², G. L. Bumgardner¹
¹Dept of Surgery, The Ohio State University, Columbus, OH, ²Center for Regen. Med., The Research Institute at Nationwide Children's Hospital, Columbus, OH
*Purpose: Kidney transplant (KTx) into CCR5 KO mice is an excellent model to study AMR immunobiology due to high alloantibody (alloAb) production, rapid allograft rejection,…
2022 American Transplant Congress
Understanding the Heterogeneity of Alloreactive Natural Killer (NK) Cell Function in Kidney Transplant Recipients
D. Ruan, M. Fribourg, N. Chun, P. Cravedi, A. Horowitz, P. Heeger
Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Emerging evidence indicates that human NK cells are a heterogeneous population of lymphocytes that are activated upon ligation of one or more activating receptors…
2022 American Transplant Congress
Bone Marrow Resident Long-Lived Plasma Cells as Source of Chronic Donor-Specific Antibodies
M. Muckenhuber, S. Pichler, A. M. Weijler, T. Wekerle
Dept. of General Surgery, Div. of Transplantation, Medical University of Vienna, Vienna, Austria
*Purpose: The importance of bone marrow resident plasma cells for long-lasting humoral immunity has been highlighted in several models for vaccination and infectious diseases. To…
2022 American Transplant Congress
A Sustained Injury Response by Regulatory T Cells (Treg) Contributes to Fibrosis to Promote Chronic Rejection After Heart Transplantation
J. Bou Saba¹, L. Fan¹, X. Zhang¹, T. Li¹, L. R. Mathews¹, G. Dwyer², E. Colon², M. J. Calderon³, K. E. Helfrich³, M. A. Ross³, S. C. Watkins³, H. Turnquist¹
¹Surgery, University of Pittsburgh, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, ²Immunology, University of Pittsburgh, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, ³Cell Biology, University of Pittsburgh, Center for Biologic Imaging, Pittsburgh, PA
*Purpose: Chronic rejection (CR) results from the development of immunosuppressant-resistant allograft vasculopathy and fibrosis and remains a leading cause of recipient death one-year post-heart transplant…
2022 American Transplant Congress
Characterization of Hepatocytes During Cold Static Preservation at Single Cell Resolution
S. Naik¹, M. Dogan¹, C. Watkins¹, A. Bajwa¹, C. Eymard², J. Eason³, C. Kuscu¹, C. Kuscu¹
¹Transplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN, ²James D. Eason Transplant Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN, ³University of Tennessee/Methodist Transplant Institute, Memphis, TN
*Purpose: Hepatocytes together with liver sinusoidal endothelial cells (LSEC) are the most affected cells during cold preservation of donor liver. Necrotic and apoptotic hepatocytes release…
2022 American Transplant Congress
A Single Center Experience of Simultaneous Heart-Kidney Transplantation
A. Samra¹, A. Mattoo²
¹Nephrology, New York University Langone Transplant Institute, New York, NY, ²New York University Langone Transplant Institute, New York, NY
*Purpose: Currently there are no UNOS guidelines regarding the selection criteria required for simultaneous heart-kidney transplant recipients (SHKT). As of 2018 our center has begun…
2022 American Transplant Congress
Production of Exosomal IL35 from Alloreactive Treg Cells: A Basis for Potent Immunotherapy and Tolerance in Human Kidney Transplantation
W. J. Burlingham¹, E. Jankowska-Gan², J. Fechner¹, C. Little¹, S. Tripathi³, B. Schreiber³, A. Chandraker³, D. Foley⁴
¹Surgery-Transplant Division, University of Wisconsin, Madison, WI, ²Surgery-Transplant Division, University of Wisconsin-Madison, Madison, WI, ³Surgery-Transplant Division, Brigham & Women's Hospital, Boston, MA, ⁴University of Wisconsin, Madison, WI
*Purpose: Treg cells make a variety of immunosuppressive products—cytokines such as IL10, TGFβ, and IL35, and enzymes such as the CD39/CD73 pair that convert extracellular…
2022 American Transplant Congress
The Addition of Bortezomib to a Rituximab Based Antibody Mediated Rejection Treatment Protocol in Lung Transplant
M. Galle, P. Stracener, K. Warrior, J. Lyons
Loyola University Medical Center, Maywood, IL
*Purpose: To evaluate the impact of antibody mediated rejection (AMR) treatment with rituximab combined with bortezomib vs. rituximab alone on patient survival, graft survival, and…
2022 American Transplant Congress
Contributions of Allogenicity and Antigen Presentation to Regulatory B Cell Suppression
K. Lee, F. Qiang, K. Deng, R. Matheson, J. Lei, C. LeGuern, J. Markmann
Center for Transplantation Sciences, Boston, MA
*Purpose: We previously generated in vitro Toll-like receptor (TLR)-activated B cells became regulatory B cells (Bregs) that suppress T cell proliferation and promote allograft tolerance.…
2022 American Transplant Congress
Sleeve Gastrectomy Reduces Need for Liver Transplantation for NASH Patients
R. A. Choudhury¹, A. Rouhi², G. Hoeltzel³, Y. Bababekov¹, A. Suarez-Pierre⁴, A. Yule¹, N. Vigneshwar⁴, N. Williams⁵, K. Dumon², J. Pomposelli¹, H. B. Moore¹, E. Pomfret¹, T. Nydam¹
¹Transplantation Surgery, University of Colorado Hospital, Aurora, CO, ²General Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, ³General Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, ⁴Cardiothoracic Surgery, University of Colorado Hospital, Aurora, CO, ⁵General Surgery, Hospital of the University of Pennsylvania, Aurora, CO
*Purpose: Non-Alcoholic Steatohepatitis (NASH) is one of the leading indications for liver transplantation (LT) in the United States. As with the current obesity epidemic, the…