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American Transplant Congress abstracts

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  • 2022 American Transplant Congress

    Safety and Efficacy of Darbepoetin Alfa Dosing Strategies in Renal Transplant Recipients

    J. A. Solis, A. Dao, T. Sam, T. Ma, A. F. Yango, B. V. Fischbach, N. Wilson

    Baylor University Medical Center, Dallas, TX

    *Purpose: Post-transplant anemia (PTA) is a common phenomenon in renal transplant recipients (RTR). There are currently no consensus guidelines for PTA, however patients are commonly…
  • 2022 American Transplant Congress

    Elevated Donor-Derived Cell-Free DNA (dd-cfDNA) in the Early Post-Transplant Period is Associated with an Increased Incidence of Adverse Clinical Outcomes in Kidney Transplant Recipients

    D. Wojciechowski1, A. Patel2, S. Anand3, J. Klein4, A. Paramesh5, P. Sood6, G. Shekhtman7, N. Agrawal7, M. Fei7, K. Qu7, D. C. Brennan8

    1University of Texas, Southwestern, Dallas, TX, 2Saint Barnabas Medical Center, Livingston, NJ, 3Intermountain Healthcare, Murray, UT, 4University of Kansas Medical Center, Kansas City, KS, 5Tulane University School of Medicine, New Orleans, LA, 6University of Pittsburgh Medical Center, Pittsburgh, PA, 7CareDx, Brisbane, CA, 8Johns Hopkins School of Medicine, Baltimore, MD

    *Purpose: Early post-transplant elevations in dd-cfDNA, even in the absence of histologic rejection or other overt pathology, have been suggested to carry a risk of…
  • 2022 American Transplant Congress

    Brain Death as a Novel Preclinical Human Model for the Advancement of Medicine

    C. Killian1, B. Orandi1, D. Anderson1, V. Kumar2, K. Stegner1, N. Budd1, S. Macedon1, A. Shunk3, P. Porrett1, J. Locke1

    1University of Alabama at Birmingham, Birmingham, AL, 2University of Alabama at Birmingham Hospital, Birmingham, AL, 3Legacy of Hope, Birmingham, AL

    *Purpose: For interventions that lack US Food and Drug Administration approval, testing is limited and relies on preclinical animal models to determine safety and efficacy.…
  • 2022 American Transplant Congress

    The Role of Gastrointestinal Pathogen PCR Testing in Liver Transplant Recipients Hospitalized with Diarrheal Illness

    C. K. Ching1, Y. R. Nobel2, M. R. Pereira3, E. C. Verna4

    1Department of Medicine, Columbia University Medical Center, New York, NY, 2Division of Digestive and Liver Diseases, Columbia University Medical Center, New York, NY, 3Division of Infectious Diseases, Columbia University Medical Center, New York, NY, 4Center for Liver Disease and Transplantation, Columbia University Medical Center, New York, NY

    *Purpose: Diarrhea is a common complication among liver transplant (LT) recipients and can result in significant morbidity. The development of PCR-based multiplex gastrointestinal (GI) pathogen…
  • 2022 American Transplant Congress

    Kidney, Lung and Liver Transplant Patients’, Kidney Transplant Candidates’ and Living Donors’ Perspectives on the Role of Patients’ Stories and Creative Writing in Transplantation: An Exploratory Study

    L. Laneuville1, F. Ballesteros Gallego2, A. Affdal2, B. Gagnon-Chainey3, L. Brassard2, P. Millot3, S. Harel3, C. Mavrikakis3, M. Malo3, M. Fortin2

    1McGill University, Montreal, QC, Canada, 2CRCHUM, Montreal, QC, Canada, 3University of Montreal, Montreal, QC, Canada

    *Purpose: Organ transplantation is associated with medical, psychological and existential challenges for patients. Patients’ experiential knowledge can help other patients facing these challenges. Patients’ stories…
  • 2022 American Transplant Congress

    Use of Viral Specific T Cell Therapy in Solid Organ Transplant Recipients – A Single Center Experience

    G. McGraw1, N. Patel2, K. Patel1, S. Bumb3, A. Govil4, M. Anand1

    1University of Cincinnati, Cincinnati, OH, 2Nephrology, University of Cincinnati, Cincinnati, OH, 3Nephrology, Internal Medicine, University of Cincinnati Medical Center, Blue Ash, OH, 4Univ of Cincinnati, Cincinnati, OH

    *Purpose: Viral infections such as BK virus (BKV), cytomegalovirus (CMV) and adenovirus after kidney transplantation negatively impact outcomes in solid organ transplant (SOT) recipients despite…
  • 2022 American Transplant Congress

    A Novel, High Throughput Droplet Digital PCR-Based Indel Quantification Method for the Detection of Circulating Donor-Derived Cell-Free DNA After Kidney Transplantation

    J. G. Verhoeven1, K. Boer1, A. M. Peeters1, M. C. Clahsen-van Groningen2, J. I. Roodnat1, J. van de Wetering1, D. Nieboer3, D. A. Bost4, C. C. Baan1, D. A. Hesselink1

    1Department of Internal Medicine, Erasmus MC Transplant Institute, Rotterdam, Netherlands, 2Department of Pathology, University Medical Center Rotterdam, Rotterdam, Netherlands, 3Department of Public Health, University Medical Center Rotterdam, Rotterdam, Netherlands, 4JETA Molecular, Utrecht, Netherlands

    *Purpose: Donor-derived cell-free DNA (ddcfDNA) is a promising minimally invasive biomarker for acute rejection (AR) in kidney transplant recipients. To assess the diagnostic value of…
  • 2022 American Transplant Congress

    Peripheral Blood Immune Cell Profiles of Corneal Transplant with and without Acute Rejection

    J. Hjortdal1, M. Griffin2, C. C. Murphy3, S. Brouard4, N. Degauque4

    1Department of Ophthalmology, Aarhus University Hospital, Aarhus, Denmark, 2National University of Ireland, Galway, Galway, Ireland, 3Royal Victoria Eye and Ear Hospital, Dublin, Ireland, 4Université de Nantes, CHU Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes, France

    *Purpose: Acute rejection (AR) of allogeneic corneal transplantation (CT) has a profound effect on subsequent graft survival, indicating that immunological damage is often not fully…
  • 2022 American Transplant Congress

    Impact of Sars-CoV-2 Vaccination on Donor-Derived Cell Free DNA Levels in Renal Transplant Recipients

    H. Alvarado Verduzco, E. Daniel, D. Kim, A. Hussain, S. Mohan, D. Cohen

    Columbia University Irving Medical Center, New York, NY

    *Purpose: COVID-19 poses a disproportionate threat to renal transplant recipients (RTR), who are chronically immunosuppressed. Studies have indicated a 16% mortality rate compared to
  • 2022 American Transplant Congress

    Detection of Early Graft Injury After Liver Transplantation with Blood-Bile Ratio of Tacrolimus: The TUBE Trial

    M. M. Pascale1, G. Bianco1, L. Ferri1, F. Giovinazzo1, A. Liguori2, G. Marrone2, A. Grieco2, S. Agnes1

    1General Surgery and Liver Transplant Unit, Fondazione IRCSS - Policlinico "A. Gemelli", Roma, Italy, 2Transplant Hepatology Unit, Fondazione IRCSS - Policlinico "A. Gemelli", Roma, Italy

    *Purpose: The aim of the“Tacrolimus in Bile”(TUBE)Trial is the creation of a laboratory parameter for the early detection of hepatic injury after liver transplant.*Methods: TUBE…
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