Am J Transplant, Volume 22, Suppl 3 Archives - Page 3 of 190 - ATC Abstracts

2022 American Transplant Congress
National Consortium Registry Insights on Management and Outcome of Hepatitis C Viremic Heart Transplants
R. Gottlieb¹, M. Salem¹, A. Ravichandran², J. Kennedy³, J. Strope⁴, S. Lin⁵, J. Chow⁶, P. Eckman⁷, S. Desai⁸, O. Larkins¹, J. Vanzyl¹, S. Hall¹
¹Baylor Scott & White Healthcare, Dallas, TX, ²Ascension Medical Group, Indianapolis, IN, ³Inova Heart and Vascular Institute, Falls Church, VA, ⁴Medical University of South Carolina, Charleston, SC, ⁵University of Washington Medical Center, Seattle, WA, ⁶Tufts Medical Center, Boston, MA, ⁷Minneapolis Heart Institute, Minneapolis, MN, ⁸Ochsner Medical Center, New Orleans, LA
*Purpose: Multicenter US registry of clinical management of HCV NAT+ hearts.*Methods: An ongoing 8-center retrospective IRB-approved registry collected baseline characteristics, labs, management, and outcomes after…
2022 American Transplant Congress
Microvascular Inflammation in Kidney Transplant Biopsies in the Absence of HLA-DSA Displays Intense Cytotoxic T-cell and NK Cell but Not Plasma Cell Infiltration
A. Buxeda¹, L. Llinàs-Mallol¹, J. Gimeno², D. Redondo-Pachón¹, C. Arias-Cabrales¹, C. Burballa¹, A. Puche², M. Pérez-Sáez¹, J. Pascual³, M. Crespo¹
¹Nephrology Department, Hospital del Mar, Institute Mar for Medical Research (IMIM), Barcelona, Spain, ²Pathology Department, Hospital del Mar, Institute Mar for Medical Research (IMIM), Barcelona, Spain, ³Nephrology Department, Hospital Universitario 12 de Octubre. Institute Mar for Medical Research (IMIM), Madrid, Spain
*Purpose: Microvascular inflammation (MVI) without evidence of HLA-donor-specific antibodies (HLA-DSA) or C4d+ deposition remains an enigmatic phenotype, which cannot be classified as antibody-mediated rejection (ABMR)…
2022 American Transplant Congress
Immunity Rates to Hepatitis B Among Solid Organ Transplant Recipients
S. Kopf¹, J. Walker², K. Bruxvoort³, H. Budhwani³, A. Nellore⁴
¹Infectious Disease, University of Alabama at Birmingham Hospital, Birmingham, AL, ²University of Alabama at Birmingham, Birmingham, AL, ³University of Alabama at Birmingham Hospital, Birmingham, AL, ⁴University of Alabama, Birmingham, AL
*Purpose: Immunosuppression after transplantation decreases vaccine responsiveness. Thus, to be best protected from post-transplant communicable diseases, vaccination of organ transplant candidates in the pre-transplant period…
2022 American Transplant Congress
A Novel Approach to Non-Invasive Multimodality Testing with Allosure and Allomap Predicts Microvascular Inflammation with High Accuracy in Kidney Transplant Recipients
S. Parajuli, F. Aziz, N. Garg, S. E. Panzer, K. Van Hyfte, K. Degner, S. Reese, L. Ptak, N. Wilson, A. Djamali
University of Wisconsin, Madison, WI
*Purpose: The most prominent histologic lesion in antibody-mediated rejection (ABMR) is microvascular inflammation (MVI); however, its recognition and scoring can be challenging and poorly reproducible…
2022 American Transplant Congress
High TTV Load Before First Vaccine Dose is Associated with Poor Serological Response to Covid-19 Vaccination in Lung Transplant Recipients
C. C. Van Leer Buter¹, R. A. Hoek², E. A. Verschuuren³, R. D. de Vries⁴, D. van Baarle¹, M. van der Heiden¹, H. G. Niesters¹, C. GeurtsvanKessel⁴
¹Dept. of Medical Microbiology, University Medical Center Groningen, Groningen, Netherlands, ²Dept. of Pulmonary Medicine, Erasmus Medical Center, Rotterdam, Netherlands, ³Dept. of Pulmonary Diseases,, University Medical Center Groningen, Groningen, Netherlands, ⁴Dept. of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands
*Purpose: Torque tenovirus (TTV), a highly prevalent virus which is not known to cause pathology in humans, is currently being investigated as a marker of…
2022 American Transplant Congress
Analysis of Sars-Cov-2-Specific T-Cell Responses Using Novel Single-Cell Multiplexed Isolight in Covid-19 Convalescents
Y. Sambandam¹, J. He¹, N. Vanderhyde², L. Gallon¹, J. Leventhal¹, J. Mathew¹
¹Northwestern University, Chicago, IL, ²IsoPlexis, Branford, CT
*Purpose: COVID-19 has poor outcomes in transplant recipients with reduced antibody responses. However, the exact cellular immune response against SARS-CoV-2 remains largely unclear. We developed…
2022 American Transplant Congress
Barriers to Completing the Transplant Evaluation Process: A Mixed-Methods Study
E. J. Gordon¹, J. J. Uriarte¹, A. N. McLagan¹, B. Kuramitsu¹, J. Gacki-Smith¹, M. Shumate², L. McElroy³, J. Caicedo¹
¹Northwestern University Feinberg School of Medicine, Chicago, IL, ²Northwestern University, Evanston, IL, ³Duke University, Durham, NC
*Purpose: Little is known about patient-reported factors affecting patients’ access to the kidney transplant waitlist after starting evaluation. We qualitatively assessed patients’ perceived barriers to…
2022 American Transplant Congress
COVID Infection Among Kidney Transplant Recipient During the Era of COVID Vaccination: Management Outcomes
G. Uehara, K. Soliman, V. Rao, M. Casey, D. Taber, M. Posadas Salas
Nephrology, Medical University of South Carolina, Charleston, SC
*Purpose: COVID pandemic has posed a significant challenge among kidney transplant recipients (KTR) due to their immunocompromised state. There is uncertainty on immunosuppression (IS) management…
2022 American Transplant Congress
Safety and Immunogenicity of BNT-162b2 versus Chadox1 Vaccine in Solid Organ Transplant Recipients: Prospective Study
A. Ajlan¹, T. Ali², H. Aleid², K. Almeshari², M. Alkaff³, S. Althuwaidi⁴, L. Fajji², A. Alali⁵, D. Halabi⁶, A. Ullah⁷, K. H. Marquez⁸, B. Elmikkaoui⁹, A. Alrajhi¹⁰, A. Zidan¹¹, E. Albogumi.¹², K. Bzeizi¹³, R. Almaghrabi¹⁴, E. DeVol¹⁵, M. Al-Awwami,¹⁶, S. Alghamdi¹³, P. Broering²
¹Pharmaceutical Care Division - Organ Transplant Centre of Excellence, King Faisal Specialist Hospital and Research Centre (KFSHRC), Riaydh, Saudi Arabia, ²Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ³Medical Laboratory, KFSHRC, Riaydh, Saudi Arabia, ⁴Medical Microbiology, KFSHRC, Riaydh, Saudi Arabia, ⁵Transplant Coordination Team - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ⁶Transplant Coordination Team - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ⁷Kidney & Pancreas Health Centre, KFSHRC, Riaydh, Saudi Arabia, ⁸Analytics Data Centre - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ⁹Data Management - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ¹⁰Infectious Diseases - Medicine Department, KFSHRC, Riaydh, Saudi Arabia, ¹¹Abdominal Transplant & Hepatobiliary Surgery Centre, KFSHRC, Riaydh, Saudi Arabia, ¹²Data Management. - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ¹³Liver & Small Bowel Health Centre, KFSHRC, Riaydh, Saudi Arabia, ¹⁴Infectious Diseases - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ¹⁵Biostatistics, Epidemiology &Scientific Computing, KFSHRC, Riaydh, Saudi Arabia, ¹⁶Histocompatibility and Immunogenetics Laboratory Kidney & Pa - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia
*Purpose: Data showed seroconversion after different SARS-CoV-2 vaccination platforms might yield diminished response in transplant recipients. However, it is unknown whether different vaccination platforms could…
2022 American Transplant Congress
Viral-Specific Cytotoxic T-Cell Responses in Hla-Sensitized Kidney Transplant Patients Maintained on Everolimus and Low Dose Tacrolimus
R. Zhang¹, S. Ge¹, M. Chu¹, J. Kahwaji², A. Karasyov¹, D. Lovato¹, A. Vo², J. Choi², M. Toyoda¹, S. Jordan²
¹Transplant Immunology Laboratory, Cedars Sinai Medical Center, Los Angeles, CA, ²Comprehensive Transplant Center, Cedars Sinai Medical Center, Los Angeles, CA
*Purpose: Post-transplant immunosuppression with “everolimus + reduced dose tacrolimus” (Ev + Taclow) is reported to reduce the risk of viral infections compared to standard doses…