ATC Abstracts

American Transplant Congress abstracts

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  • 2022 American Transplant Congress

    Autologous Mesenchymal Stem Cells for Treatment of Chronic Antibody-Mediated Kidney Graft Rejection: Report of the First Phase I/II Clinical Case Series

    Ž. Večerić-Haler1, M. Sever2, N. Kojc3, G. Mlinšek1, M. Oblak1, P. Halloran4, A. Aleš Rigler1, J. Buturović Ponikvar1, M. Arnol5

    1Nephrology, UMC Ljubljans, Ljubljana, Slovenia, 2Haematology, UMC Ljubljans, Ljubljana, Slovenia, 3Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana,, Ljubljana, Slovenia, 4Division of Nephrology and Transplant Immunology, University of Alberta, Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, 5University Medical Centre Ljubljana, Ljubljana, Slovenia

    *Purpose: The aim of this study is to evaluate the safety and efficacy of autologous mesenchymal stem cellc (MSCs) in combination with standard of care…
  • 2022 American Transplant Congress

    Successful Transplantation of CPRA 95-100% HLA Incompatible (HLA I) KPD Candidates: A New Combined KPD Matching Strategy at a Single Centre

    H. Helwani1, D. Broering2, I. Alahmadi3, T. Ali1, F. Alzayer4, M. Mankowski5, A. Algharabli1

    1Kidney & Pancreas Health Centre, OTCoE, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia, 2Organ Transplant Centre of Excellence, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia, 3Kidney & Pancreas Transplant Surgery, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia, 4King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia, 5King Abdullah University for Science & Technology, Saudi Arabia, Saudi Arabia

    *Purpose: The six components of the new strategy are Universal flexible assignments of unacceptable antigens (UA); individualized deletion of carefully selected UA; inclusion of compatible…
  • 2022 American Transplant Congress

    Preoperative Antibiotics Administration is Important to Prevent Hand Port-Site Infection After Hand-Assisted Laparoscopic Donor Nephrectomy for Living-Donor Kidney Transplantation

    T. Hiramitsu, T. Tomosugi, K. Futamura, M. Okada, N. Goto, T. Ichimori, S. Narumi, Y. Watarai

    Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan

    *Purpose: Due to the profound organ shortage, the number of living donor kidney transplantation (LDKT) is increasing. Hand-assisted laparoscopic donor nephrectomy (HALDN) is widely performed…
  • 2022 American Transplant Congress

    Increasing Proportion of High-Risk Cytomegalovirus (CMV) Donor Positive/recipient Negative (D+R-) Serostatus in Solid Organ Transplant Recipients (SOTRs)

    H. Imlay1, M. M. Wagener2, N. Singh2, A. P. Limaye3

    1University of Utah, Salt Lake City, UT, 2University of Pittsburgh, Pittsburgh, PA, 3University of Washington, Seattle, WA

    *Purpose: CMV D+R- serostatus is independently associated with worse long-term graft and patient survival across many organ transplant types despite current prevention and treatment strategies.…
  • 2022 American Transplant Congress

    Deletion of Fibroblastic Reticular Cell Derived Laminin A4 Impairs Lymph Node Vasculature and Conduits

    L. Li1, M. Shirkey1, W. Piao1, A. Kensiski1, V. Saxena1, T. Zhang1, X. Li2, J. Zhao2, S. Gavzy1, R. Abdi2, J. Bromberg1

    1UMB, Baltimore, MD, 2Harvard University, Boston, MA

    *Purpose: Fibroblastic reticular cells (FRCs) support lymph node (LN) structure by producing various functional extracellular matrix (ECM) components. We hypothesized that FRCs and their ECM…
  • 2022 American Transplant Congress

    Status Exception Use in the New Seven-Tiered Heart Allocation System

    A. Plana1, A. Kanelidis1, W. F. Parker2, V. Jeevanandam3, C. Salerno3, B. Smith1, S. Kalantari1, S. Pinney1, J. Grinstein1

    1Cardiology, University of Chicago, Chicago, IL, 2Pulmonary/Critical Care, University of Chicago, Chicago, IL, 3Cardiac Surgery, University of Chicago, Chicago, IL

    *Purpose: The revised seven-tiered US heart allocation policy aimed to improve risk stratification to lower exception status use. However, recent literature has demonstrated that exceptions…
  • 2022 American Transplant Congress

    Antibody-Mediated Rejections with C1q-binding and without C1-Binding Donor-Specific Antibodies in Kidney Transplantation

    J. Jeon, C. Baek

    Asan Medical Center, Seoul, Korea, Republic of

    *Purpose: All donor-specific antibodies (DSAs) are not clinically relevant. Therefore, the C1q assay has been recently used, but its clinical meaning and usefulness should be…
  • 2022 American Transplant Congress

    Desensitization Protocol Consisting of High-Dose Intravenous Immunoglobulin, Plasmapheresis, and Rituximab in Highly Sensitized Kidney Transplant Recipients

    M. Okada, T. Hiramitsu, T. Tomosugi, K. Futamura, S. Narumi, N. Goto, Y. Watarai

    Nagoya Daini Red Cross Hospital, Nagoya, Japan

    *Purpose: In HLA incompatible kidney transplantation, donor-specific HLA antibody often causes antibody-mediated rejection (AMR). To prevent AMR, we adopted a preoperative desensitization protocol including high-dose…
  • 2022 American Transplant Congress

    HLA Alleles Add to Risk Stratification for CMV Infection in Renal Transplant Recipients

    R. Patil1, R. Prashar2, M. Ramesh2, A. Patel2

    1Wayne State University School of Medicine, Detroit, MI, 2Henry Ford Transplant Institute, Detroit, MI

    *Purpose: Cytomegalovirus (CMV) is the most common viral infection that occurs after solid organ transplantation. The incidence of CMV infection or disease (I/d) varies based…
  • 2022 American Transplant Congress

    Discordant Histological Findings During Acute Rejection in a Combined Face and Hand Transplant Recipient

    O. C. Onuh1, J. Trilles1, W. J. Rifkin1, H. Brydges1, B. F. Chaya1, R. Rodriguez Colon1, D. Boczar1, D. J. Ceradini1, E. D. Rodriguez1, B. E. Gelb2

    1Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health, New York, NY, 2Transplant Institute, NYU Langone Health, New York, NY

    *Purpose: The purpose of this study is to evaluate histologic findings in a face and bilateral hand transplant recipient that was monitored with multi-site allograft…
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