2022 American Transplant Congress
Single Cell RNAseq Analysis of Liver Transplant Rejection Reveals Highly Restricted TCR Clonal Expansion of Tissue-Resident Memory CD8+ T Cells That Persist Despite Corticosteroids and ATG Therapy
*Purpose: Conventional therapy for liver transplant rejection (corticosteroids and ATG) has remained unchanged for six decades, and is not infrequently met with treatment failure. Here,…2022 American Transplant Congress
Chronic Ethanol Exposure Prolongs Murine Allograft Survival
Department of Surgery, Emory University, Atlanta, GA
*Purpose: Alcoholic liver disease is the leading indication for liver transplantation in the United States, and patients are increasingly transplanted without the traditional six month…2022 American Transplant Congress
Association Between Allograft Gene Expression and Acute Cellular Rejection Grade in Heart Transplant Recipients
*Purpose: Endomyocardial biopsy (EMB) remains the gold standard in acute rejection (AR) surveillance in heart transplantation (HT) despite interpretation subjectivity and low concordance rates between…2022 American Transplant Congress
Generation and Functional Characterization of Bio-Engineered Livers for Heterotopic Implantation in Porcine Model of Acute Liver Failure
*Purpose: Liver transplantation has shown to be an effective therapy for the end-stage liver diseases (ESLD). However, as donor organ shortages increase, organ engineering technology…2022 American Transplant Congress
Bionic Pancreas – 3D Bioprinting of a Bionic Organ with a Vascular System – Results of Transplantation in Large Animals
*Purpose: There is lack organs for transplantation. The transplantation of the pancreas is recommended in diabetes with complications. The combination of cell biology and 3D-bioprinting…2022 American Transplant Congress
QSant, a Novel Urine Test Monitors Recovery of Allograft Injury After DGF
1Nephrosant, Brisbane, CA, 2Hospital do Rim, Sao Paolo, Brazil
*Purpose: We evaluate urine QSant assay to non-invasively monitor recovery of allograft injury, post delayed graft function(DGF).*Methods: 65 HLA-DR matched, renal allograft recipients, on TAC/MMF/prednisone…2022 American Transplant Congress
A Third Dose of SARS-CoV-2 Vaccine Increases Neutralizing Antibodies Against Variants of Concern in Solid Organ Transplant Recipients
*Purpose: Vaccine-induced SARS-CoV-2 antibody responses are attenuated in solid organ transplant recipients (SOTRs) and breakthrough infections are more common. Additional SARS-CoV-2 vaccine doses increase anti-spike…2022 American Transplant Congress
Concurrent Use of Two Methods Prevents Erroneous HLA Typing of Deceased Organ Donors – An Essential Strategy for Patient Safety and Accurate Virtual Crossmatching for Broader Sharing
*Purpose: Comprehensive and accurate typing for ever-increasing alleles of all eleven HLA genes within a short turnaround time is a crucial initial step for allocating…2022 American Transplant Congress
The Impact of New-Onset Diabetes After Transplantation on Survival and Major Cardiovascular Events in Korean Kidney Transplantation Recipients
*Purpose: New-onset diabetes after transplantation (NODAT) is a frequent complication in kidney transplant (KT) recipients with unfavorable outcomes, although a nationwide study on epidemiology and…2022 American Transplant Congress
Team Decision-Making in Liver Transplant Evaluation: A Multi-Center Ethnographic Observation Study
Johns Hopkins School of Medicine, Baltimore, MD
*Purpose: Transplant providers are tasked with making ethically complex and high-stakes decisions of determining a patient’s candidacy for liver transplantation within a multi-disciplinary team. We…
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